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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| VSNL1 | 7447 | visinin-like 1 | 2 | VILIP, HPCAL3, HUVISL1, HLP3, VILIP-1 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22052372 | 2012 | Cell line : - Source : Oita University . Sample Type : CRC tumor and normal tissue No. of Sample : 24 Stage : TNM Stage I-III. | Immunohistochemistry,real time RT-PCR | Up-regulation | - | VSNL-1 at the mRNA level, suggesting the possible usefulness of VSNL-1 as a predictor of lymph node metastasis and poor prognosis in CRC. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | EF-hand domain containing |
| Description | This gene is a member of the visinin/recoverin subfamily of neuronal calcium sensor proteins. The encoded protein is strongly expressed in granule cells of the cerebellum where it associates with membranes in a calcium-dependent manner and modulates intracellular signaling pathways of the central nervous system by directly or indirectly regulating the activity of adenylyl cyclase. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008] | Chromosome | 2 |
| Location | 2p24.3 |
| Start | 17721807 |
| End | 17837706 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 115900 |
| OMIM ID | 600817 |
| HGNC ID | HGNC:12722 |
| Unigene ID | Hs.444212 |
| Ensembl ID | ENSG00000163032 |
| PharmGKB ID | PA37333 |
mRNA Information
| mRNA ID | ?NM_003385.4 |
|---|---|
| Exon | join(1..379,51531..51697,108871..109086,114658..115900) | mRNA Sequence | Download Select all |
| Length | 2014 |
Protein Information
| Protein ID | NP_003376.2 |
|---|---|
| Protein Name | visinin-like 1 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 191 |
| Uniprot ID | Q86V81 |
| Ensembl Protein ID | ENSP00000331817 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| G | Myristoylation | 2 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 60 | ACTB | 32 | NP_001092.1 | in vivo | 8780737 |
| 1137 | CHRNA4 | 333 | NP_000735.1 | in vitro;in vivo;yeast 2-hybrid | 12202488 |
| 8328 | GFI1B | 5088 | NP_004179.3 | yeast 2-hybrid | 16713569 |
| 113878 | DTX2 | 16841 | NP_065943.2 | yeast 2-hybrid | 16189514 |
| 348487 | FAM131C | 8779 | NP_872429.2 | yeast 2-hybrid | 16189514 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00051 | 65-125 | EFh |
| cl08302 | 65-125 | EFh superfamily |
| cd00051 | 100-176 | EFh |
| cl08302 | 100-176 | EFh superfamily |
| cd00051 | 40-90 | EFh |
| smart00054 | 66-90 | EFh |
| cl23347 | 66-90 | EFh superfamily |
| pfam00036 | 66-90 | EF-hand_1 |
| cl23489 | 66-90 | EF-hand_1 superfamily |
| smart00054 | 100-128 | EFh |
| pfam13405 | 66-90 | EF-hand_6 |
| cl23634 | 66-90 | EF-hand_6 superfamily |
| smart00054 | 151-177 | EFh |
| cl23347 | 151-177 | EFh superfamily |
| cd00052 | 105-171 | EH |
| pfam13833 | 76-120 | EF-hand_8 |
| pfam13833 | 39-86 | EF-hand_8 |
| cl08302 | 39-86 | EFh superfamily |
| pfam00036 | 150-177 | EF-hand_1 |
| cl23489 | 150-177 | EF-hand_1 superfamily |
| COG5126 | 15-181 | FRQ1 |
| PTZ00183 | 68-176 | PTZ00183 |
| pfam13499 | 107-174 | EF-hand_7 |
| PTZ00184 | 73-171 | PTZ00184 |
| pfam13499 | 70-125 | EF-hand_7 |
| pfam13499 | 40-89 | EF-hand_7 |
| PRK12309 | 105-170 | PRK12309 |
| PTZ00183 | 73-179 | PTZ00183 |
Ontology Information
| HPRD ID | 3704 |
|---|---|
| Molecular Class | Calcium binding protein |
| Molecular Function | Antigen binding (GO:0003823) |
| Biological Process | Immune response (GO:0006955) |
Drug Information
No matching records could be found.