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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| VTI1A | 143187 | vesicle transport through interaction with t-SNAREs 1A | 10 | MVti1, Vti1a, Vti1-rp2 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24608966 | 2014 | Cell line : - Source : Hospitals in the Oslo region, Norway. Sample Type : CRC tumor No. of Sample : 106 CRC and 14 paired normal tissue Stage : TNM Stage II-IV. | High-throughput DNA and RNA sequencing,nested RT-PCR | Polymorhpism | - | - |
| 25105248 | 2014 | Cell line : - Source : Cancer Research Bank (Tokyo, Japan), Kyushu University Beppu Hospital. Sample Type : Population based case control study. No. of Sample : 2,627 cases and 3,797 controls of Japanese ancestry and 1,894 cases and 4,703 controls of African ancestry,16,823 cases and 18,211 controls of European ancestry. Stage : - | Meta analysis | Polymorhpism | - | This study reveals a new pan-ethnic CRC risk locus at 10q25 (rs12241008, intronic to VTI1A; P=1.4 � 10(-9)), providing additional insight into the aetiology of CRC. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene is a member of the family of soluble N-ethylmaleimide-sensitive fusion protein-attachment protein receptors (SNAREs) that function in intracellular trafficking. This family member is involved in vesicular transport between endosomes and the trans-Golgi network. It is a vesicle-associated SNARE (v-SNARE) that interacts with target membrane SNAREs (t-SNAREs). Polymorphisms in this gene have been associated with binocular function, and also with susceptibility to colorectal and lung cancers. A recurrent rearrangement has been found between this gene and the transcription factor 7-like 2 (TCF7L2) gene in colorectal cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015] | Chromosome | 10 |
| Location | 10q25.2 |
| Start | 114206756 |
| End | 114578503 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 371748 |
| OMIM ID | 614316 |
| HGNC ID | HGNC:17792 |
| Unigene ID | Hs.194554 |
| Ensembl ID | ENSG00000151532 |
| PharmGKB ID | PA134928049 |
Protein Information
| Protein ID | NP_660207.2 |
|---|---|
| Protein Name | vesicle transport through interaction with t-SNAREs 1A |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 217 |
| Uniprot ID | Q5SW24 |
| Ensembl Protein ID | ENSP00000355760 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 3 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 8675 | STX16 | 4718 | NP_001001433.1 | in vivo | 11839770 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| SNARE interactions in vesicular transport | hsa04130 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd15891 | 122-183 | SNARE_Vti1a |
| cl22856 | 122-183 | SNARE superfamily |
| pfam05008 | Dec-90 | V-SNARE |
| cl09350 | Dec-90 | V-SNARE superfamily |
| pfam12352 | 123-188 | V-SNARE_C |
| cl18053 | 123-188 | V-SNARE_C superfamily |
| cd15862 | 122-183 | SNARE_Vti1 |
| cd15890 | 122-183 | SNARE_Vti1b |
| smart00397 | 120-184 | t_SNARE |
| cd15861 | 137-183 | SNARE_SNAP25N_23N_29N_SEC9N |
Ontology Information
| HPRD ID | 6330 |
|---|---|
| Molecular Class | Transport/cargo protein |
| Molecular Function | Metallopeptidase activity (GO:0008237) |
| Biological Process | Protein metabolism (GO:0019538) |
Drug Information
No matching records could be found.