Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| WASF1 | 8936 | WAS protein family, member 1 | 6 | WAVE1, SCAR1, KIAA0269, WAVE |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 17390011 | 2007 | Cell line : - Source : - Sample Type : CRC tumor and normal tissues No. of Sample : - Stage : - | Genomic and transcriptomic profiling | Up-regulation | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | A-kinase anchor proteins |
| Description | The protein encoded by this gene, a member of the Wiskott-Aldrich syndrome protein (WASP)-family, plays a critical role downstream of Rac, a Rho-family small GTPase, in regulating the actin cytoskeleton required for membrane ruffling. It has been shown to associate with an actin nucleation core Arp2/3 complex while enhancing actin polymerization in vitro. Wiskott-Aldrich syndrome is a disease of the immune system, likely due to defects in regulation of actin cytoskeleton. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] | Chromosome | 6 |
| Location | 6q21 |
| Start | 110421022 |
| End | 110501219 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 80198 |
| OMIM ID | 605035 |
| HGNC ID | HGNC:12732 |
| Unigene ID | Hs.75850 |
| Ensembl ID | ENSG00000112290 |
| PharmGKB ID | PA37343 |
Protein Information
| Protein ID | NP_001020105.1 |
|---|---|
| Protein Name | WAS protein family, member 1 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 559 |
| Uniprot ID | O95600 |
| Ensembl Protein ID | ENSP00000364063 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 310 |
| S | Phosphorylation | 397 |
| S | Phosphorylation | 441 |
| S | Phosphorylation | 310 |
| S | Phosphorylation | 397 |
| S | Phosphorylation | 441 |
| S | Phosphorylation | 310 |
| S | Phosphorylation | 397 |
| S | Phosphorylation | 441 |
| S | Phosphorylation | 91 |
| T | Phosphorylation | 96 |
| S | Phosphorylation | 91 |
| T | Phosphorylation | 96 |
| S | Phosphorylation | 91 |
| T | Phosphorylation | 96 |
| S | Phosphorylation | 91 |
| T | Phosphorylation | 96 |
| S | Phosphorylation | 298 |
| S | Phosphorylation | 298 |
| S | Phosphorylation | 298 |
| S | Phosphorylation | 298 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 25 | ABL1 | 1809 | NP_009297.2 | in vitro;in vivo | 10970852 |
| 60 | ACTB | 32 | NP_001092.1 | in vitro | 10381382 |
| 572 | BAD | 4409 | NP_004313.1 | in vivo | 12931191 |
| 998 | CDC42 | 309 | NP_001782.1 | in vitro;in vivo | 1 218 157 015 834 150 |
| 1398 | CRK | 1267 | NP_058431.2 | in vitro;in vivo | 15834156 |
| 2534 | FYN | 655 | NP_002028.1 | in vivo | 10532312 |
| 2885 | GRB2 | 150 | NP_002077.1 | in vitro;in vivo | 9307968 |
| 3576 | IL8 | 909 | NP_000575.1 | in vitro | 16862120 |
| 3592 | IL12A | 1193 | NP_000873.2 | in vitro | 16862120 |
| 4690 | NCK1 | 2740 | NP_006144.1 | in vitro;in vivo | 8605018 |
| 5216 | PFN1 | 1452 | NP_005013.1 | in vitro;in vivo | 9843499 |
| 5879 | RAC1 | 3627 | NP_061485.1 | in vivo | 9843499 |
| 10006 | ABI1 | 4336 | NP_005461.2 | in vitro | 15048123 |
| 10097 | ACTR2 | 5023 | NP_001005386.1 | in vitro | 15834156 |
| 10787 | NCKAP1 | 5353 | NP_995314.1 | in vitro;in vivo | 121 815 708 605 018 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Adherens junction | hsa04520 |
| Bacterial invasion of epithelial cells | hsa05100 |
| Choline metabolism in cancer | hsa05231 |
| Fc gamma R-mediated phagocytosis | hsa04666 |
| Regulation of actin cytoskeleton | hsa04810 |
| Salmonella infection | hsa05132 |
| Shigellosis | hsa05131 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam02205 | 494-521 | WH2 |
| cl08342 | 494-521 | WH2 superfamily |
| smart00246 | 497-514 | WH2 |
| cl02527 | 497-514 | WH2 superfamily |
| pfam02166 | 397-525 | Androgen_recep |
Ontology Information
| HPRD ID | 9352 |
|---|---|
| Molecular Class | Adapter molecule |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.