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General Information
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22752057 | 2012 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Real-time PCR , oligonucleotide microarray . | Up-regulation | - | �Patients with high expression of IL8 and�WDR77, and low expression of MYL9 and VIP had a significantly reduced median survival rate compared to colon�cancer�patients. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | WD repeat domain containing |
| Description | The protein encoded by this gene is an androgen receptor coactivator that forms a complex with protein arginine methyltransferase 5, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins. The encoded protein may be involved in the early stages of prostate cancer, with most of the protein being nuclear-localized in benign cells but cytoplasmic in cancer cells. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015] | Chromosome | 1 |
| Location | 1p13.2 |
| Start | 111982512 |
| End | 111991915 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 9404 |
| OMIM ID | 611734 |
| HGNC ID | HGNC:29652 |
| Unigene ID | Hs.204773 |
| Ensembl ID | ENSG00000116455 |
| PharmGKB ID | PA142670581 |
Protein Information
| Protein ID | NP_077007.1 |
|---|---|
| Protein Name | WD repeat domain 77 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 342 |
| Uniprot ID | Q9BPY8 |
| Ensembl Protein ID | ENSP00000315198 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| T | Phosphorylation | 5;- |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 6628 | SNRPB | 1655 | NP_937859.1 | in vitro | 11756452 |
| 6632 | SNRPD1 | 3040 | NP_008869.1 | in vitro | 11756452 |
| 6633 | SNRPD2 | 3038 | NP_004588.1 | in vitro | 11756452 |
| 6634 | SNRPD3 | 3039 | NP_004166.1 | in vitro | 11756452 |
| 6635 | SNRPE | 548 | NP_003085.1 | in vitro | 11756452 |
| 6636 | SNRPF | 4645 | NP_003086.1 | in vitro | 11756452 |
| 10971 | YWHAQ | 886 | NP_006817.1 | in vivo | 15324660 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00200 | 80-319 | WD40 |
| cl02567 | 80-319 | WD40 superfamily |
| cd00200 | 80-282 | WD40 |
| cd00200 | 122-326 | WD40 |
| cd00200 | 91-196 | WD40 |
| cd00200 | 163-322 | WD40 |
| pfam00400 | 158-196 | WD40 |
| smart00320 | 159-196 | WD40 |
| pfam00400 | 124-153 | WD40 |
| COG2319 | 98-329 | WD40 |
| COG2319 | 45-322 | WD40 |
| COG2319 | 122-322 | WD40 |
| COG2319 | 80-198 | WD40 |
| COG3391 | 124-296 | YncE |
Ontology Information
| HPRD ID | 9871 |
|---|---|
| Molecular Class | Unclassified |
| Molecular Function | Receptor signaling complex scaffold activity (GO:0030159) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.