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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| WISP1 | 8840 | WNT1 inducible signaling pathway protein 1 | 8 | CCN4 |
- Evidence
- Gene
- mRNA
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- Protein
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 16041507 | 2006 | Cell line : - Source : Kuala Lumpur Hospital (KLH) . Sample Type : Formalin-fixed, paraffin-embedded tissue No. of Sample : 47 Stage : - | Immunohistochemistry | Up-regulation | - | Overexpression and interplay between Wnt-1, WISP-1, survivin and cyclin-D1 may play a role in tumorigenesis. |
| 17657846 | 2007 | Cell line : - Source : - Sample Type : CRC Tumor and normal tissue No. of Sample : 86 Stage : - | real time RT-PCR,immunohistochemisttry | Up-regulation | - | Aberrant levels of WISP-1 expression may play a role in rectal tumorigenesis. WISP-1 may be used as a specific clinical diagnosis and prognosis marker in rectal cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid level. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2011] | Chromosome | 8 |
| Location | 8q24.22 |
| Start | 134203282 |
| End | 134243933 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 40652 |
| OMIM ID | 603398 |
| HGNC ID | HGNC:12769 |
| Unigene ID | Hs.492974 |
| Ensembl ID | ENSG00000104415 |
| PharmGKB ID | PA37372 |
Protein Information
| Protein ID | NP_001191798.1 |
|---|---|
| Protein Name | WNT1 inducible signaling pathway protein 1 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 367 |
| Uniprot ID | Q9NS23 |
| Ensembl Protein ID | ENSP00000333327 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 633 | BGN | 2359 | NP_001702.1 | in vitro | 11598131 |
| 1634 | DCN | 501 | NP_001911.1 | in vitro | 11598131 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00219 | 54-101 | IGFBP |
| cl02472 | 54-101 | IGFBP superfamily |
| smart00214 | 123-181 | VWC |
| cl17735 | 123-181 | VWC superfamily |
| pfam00093 | 123-182 | VWC |
| smart00121 | 52-109 | IB |
| pfam00090 | 220-259 | TSP_1 |
| cl15278 | 220-259 | TSP_1 superfamily |
| smart00209 | 220-260 | TSP1 |
Ontology Information
| HPRD ID | 5084 |
|---|---|
| Molecular Class | Growth factor |
| Molecular Function | Protein serine/threonine kinase activity (GO:0004674) |
| Biological Process | Signal transduction (GO:0007165); Regulation of cell cycle (GO:0000074) |
Drug Information
No matching records could be found.