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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| WISP3 | 8838 | WNT1 inducible signaling pathway protein 3 | 6 | PPD; CCN6; LIBC; PPAC |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 15802015 | 2005 | Cell line : - Source : Hospitals in the Oslo and Akershus region. Sample Type : CRC tumor and normal tissue No. of Sample : 310 CRC Stage : - | Methylation-Specific PCR ,Sequencing,Frameshift Mutation Analysis, Mutation Screening | Mutation | - | A consecutive series of primary tumors from 310 CRC patients, 158 males and 151 females, collected from seven hospitals in the aslo and Akershus region. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene is overexpressed in colon tumors. It may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Mutations of this gene are associated with progressive pseudorheumatoid dysplasia, an autosomal recessive skeletal disorder, indicating that the gene is essential for normal postnatal skeletal growth and cartilage homeostasis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] | Chromosome | 6 |
| Location | 6q21 |
| Start | 112053516 |
| End | 112069686 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 16171 |
| OMIM ID | 603400 |
| HGNC ID | HGNC:12771 |
| Unigene ID | Hs.558428 |
| Ensembl ID | ENSG00000112761 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | XM_011536222.1 |
|---|---|
| Exon | join(1..143,820..890,7476..7773,11240..11271,13454..13517, 14690..14713) | mRNA Sequence | Download Select all |
| Length | 632 |
CDS Information
| Location | join(29..143,820..890,7476..7773,11240..11271, 13454..13489) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | - |
Protein Information
| Protein ID | NP_003871.1 |
|---|---|
| Protein Name | WNT1 inducible signaling pathway protein 3 |
| Molecular Wt. (Da) | 36841 |
| Protein Sequence | Download Select all |
| Length | 354 |
| Uniprot ID | P24530 |
| Ensembl Protein ID | ENSP00000335311 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00219 | 53-100 | IGFBP |
| cl02472 | 53-100 | IGFBP superfamily |
| smart00121 | 51-108 | IB |
| smart00041 | 275-341 | CT |
| cl21545 | 275-341 | GHB_like superfamily |
| pfam00090 | 214-252 | TSP_1 |
| cl15278 | 214-252 | TSP_1 superfamily |
Ontology Information
| HPRD ID | 2754 |
|---|---|
| Molecular Class | Growth factor |
| Molecular Function | Receptor binding (GO:0005102) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.