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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| WNT1 | 7471 | wingless-type MMTV integration site family, member 1 | 12 | - |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21678109 | 2011 | Cell line : - Source : Military Institute of the Health Services in Warsaw Sample Type : CRC Tumor and normal tissue No. of Sample : 66 Stage : TNM Stage I,II,III | - | Up-regulation | - | - |
| 26168479 | 2015 | Cell line : - Source : - Sample Type : CRC Tumor and normal tissue No. of Sample : 201 Stage : - | Multivariate analysis, Immunohistochemistry | Up-regulation | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Wingless-type MMTV integration sites, "Endogenous ligands" |
| Description | The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is very conserved in evolution, and the protein encoded by this gene is known to be 98% identical to the mouse Wnt1 protein at the amino acid level. The studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum. This gene was originally considered as a candidate gene for Joubert syndrome, an autosomal recessive disorder with cerebellar hypoplasia as a leading feature. However, further studies suggested that the gene mutations might not have a significant role in Joubert syndrome. This gene is clustered with another family member, WNT10B, in the chromosome 12q13 region. [provided by RefSeq, Jul 2008] | Chromosome | 12 |
| Location | 12q13 |
| Start | 49372236 |
| End | 49376396 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 4161 |
| OMIM ID | 164820 |
| HGNC ID | HGNC:12774 |
| Unigene ID | Hs.248164 |
| Ensembl ID | - |
| PharmGKB ID | PA37376 |
mRNA Information
| mRNA ID | ?NM_005430.3 |
|---|---|
| Exon | join(1..302,1016..1269,1972..2237,2700..4161) | mRNA Sequence | Download Select all |
| Length | 2284 |
Protein Information
| Protein ID | NP_005421.1 |
|---|---|
| Protein Name | wingless-type MMTV integration site family, member 1 |
| Molecular Wt. (Da) | 37601 |
| Protein Sequence | Download Select all |
| Length | 370 |
| Uniprot ID | Q99795 |
| Ensembl Protein ID | ENSP00000356842 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 4040 | LRP6 | 4617 | NP_002327.2 | in vivo | 1 102 900 711 448 770 |
| 4041 | LRP5 | 4616 | NP_002326.2 | in vitro | 11336703 |
| 89780 | WNT3A | 5897 | NP_149122.1 | in vivo | 10557084 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Basal cell carcinoma | hsa05217 |
| Hedgehog signaling pathway | hsa04340 |
| Hippo signaling pathway | hsa04390 |
| HTLV-I infection | hsa05166 |
| Melanogenesis | hsa04916 |
| Pathways in cancer | hsa05200 |
| Proteoglycans in cancer | hsa05205 |
| Signaling pathways regulating pluripotency of stem cells | hsa04550 |
| Wnt signaling pathway | hsa04310 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| smart00097 | 60-370 | WNT1 |
| cl19568 | 60-370 | wnt superfamily |
| pfam00110 | 59-370 | wnt |
Ontology Information
| HPRD ID | 5583 |
|---|---|
| Molecular Class | Secreted polypeptide |
| Molecular Function | Transporter activity (GO:0005215) |
| Biological Process | Transport (GO:0006810) |
Drug Information
No matching records could be found.