Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| WNT10B | 7480 | wingless-type MMTV integration site family, member 10B | 12 | WNT-12, SHFM6 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 10507776 | 1999 | Cell line : - Source : John Radcliffe Hospital, Oxford. Sample Type : CRC tumor and normal tissue No. of Sample : 14 Stage : - | In situ hybridization,Immunostaining | Up-regulation | - | wnts 4, 7b, 10b and 13, but not wnt 2 and wnt 5a were detected in several�colorectal�cell lines.� |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Wingless-type MMTV integration sites |
| Description | The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It may be involved in breast cancer, and its protein signaling is likely a molecular switch that governs adipogenesis. This protein is 96% identical to the mouse Wnt10b protein at the amino acid level. This gene is clustered with another family member, WNT1, in the chromosome 12q13 region. [provided by RefSeq, Jul 2008] | Chromosome | 12 |
| Location | 12q13 |
| Start | 49359123 |
| End | 49365641 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 6519 |
| OMIM ID | 601906 |
| HGNC ID | HGNC:12775 |
| Unigene ID | Hs.91985 |
| Ensembl ID | ENSG00000169884 |
| PharmGKB ID | PA37377 |
mRNA Information
| mRNA ID | ?NM_003394.3 |
|---|---|
| Exon | join(1..404,1290..1403,1508..1770,3540..3913,5306..6519) | mRNA Sequence | Download Select all |
| Length | 2370 |
Protein Information
| Protein ID | NP_003385.2 |
|---|---|
| Protein Name | wingless-type MMTV integration site family, member 10B |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 389 |
| Uniprot ID | Q9Y6N6 |
| Ensembl Protein ID | ENSP00000354360 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| T | Phosphorylation | 46 |
| T | Phosphorylation | 50 |
| S | Phosphorylation | 52 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Basal cell carcinoma | hsa05217 |
| Hedgehog signaling pathway | hsa04340 |
| Hippo signaling pathway | hsa04390 |
| HTLV-I infection | hsa05166 |
| Melanogenesis | hsa04916 |
| Pathways in cancer | hsa05200 |
| Proteoglycans in cancer | hsa05205 |
| Signaling pathways regulating pluripotency of stem cells | hsa04550 |
| Wnt signaling pathway | hsa04310 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00110 | 47-389 | wnt |
| cl19568 | 47-389 | wnt superfamily |
| smart00097 | 50-389 | WNT1 |
Ontology Information
| HPRD ID | 4245 |
|---|---|
| Molecular Class | Ligand |
| Molecular Function | Transcription regulator activity (GO:0030528) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.