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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| WNT8B | 7479 | wingless-type MMTV integration site family, member 8B | 10 | - |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 11788899 | 2002 | Cell line : KATO-III, MKN45 Source : - Sample Type : - No. of Sample : - Stage : - | Northern blotting | Up-regulation | - | WNT8B was significantly up-regulated in gastric cancer cell lines KATO-III (signet-ring cell carcinoma) and MKN45 (poorly differentiated adenocarcinoma), and also in 5 out of 10 cases of primary gastric cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Wingless-type MMTV integration sites |
| Description | The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 95%, 86% and 71% amino acid identity to the mouse, zebrafish and Xenopus Wnt8B proteins, respectively. The expression patterns of the human and mouse genes appear identical and are restricted to the developing brain. The chromosomal location of this gene to 10q24 suggests it as a candidate gene for partial epilepsy. [provided by RefSeq, Jul 2008] | Chromosome | 10 |
| Location | 10q24 |
| Start | 102222812 |
| End | 102243399 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 20588 |
| OMIM ID | 601396 |
| HGNC ID | HGNC:12789 |
| Unigene ID | Hs.421281 |
| Ensembl ID | ENSG00000075290 |
| PharmGKB ID | PA37390 |
mRNA Information
| mRNA ID | ?NM_003393.3 |
|---|---|
| Exon | join(1..182,15998..16031,16820..16958,17944..18069, 18858..19000,19217..20588) | mRNA Sequence | Download Select all |
| Length | 1996 |
Protein Information
| Protein ID | NP_003384.2 |
|---|---|
| Protein Name | wingless-type MMTV integration site family, member 8B |
| Molecular Wt. (Da) | 40026 |
| Protein Sequence | Download Select all |
| Length | 351 |
| Uniprot ID | O96013 |
| Ensembl Protein ID | ENSP00000326864 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Basal cell carcinoma | hsa05217 |
| Hedgehog signaling pathway | hsa04340 |
| Hippo signaling pathway | hsa04390 |
| HTLV-I infection | hsa05166 |
| Melanogenesis | hsa04916 |
| Pathways in cancer | hsa05200 |
| Proteoglycans in cancer | hsa05205 |
| Signaling pathways regulating pluripotency of stem cells | hsa04550 |
| Wnt signaling pathway | hsa04310 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| smart00097 | 23-333 | WNT1 |
| cl19568 | 23-333 | wnt superfamily |
| pfam00110 | 41-333 | wnt |
Ontology Information
| HPRD ID | 16116 |
|---|---|
| Molecular Class | Ligand |
| Molecular Function | Transcription regulator activity (GO:0030528) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.