Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| WRAP53 | 55135 | WD repeat containing, antisense to TP53 | 17 | FLJ10385, TCAB1 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22805008 | 2012 | Cell line : - Source : Swedish clinical trial Sample Type : CRC tumor and normal tissues No. of Sample : Normal mucosa, primary tumors and lymph node metastases from 143 rectal cancer patients Stage : - | Immunohistochemistry | Up-regulation | - | WRAP53 may be a new biomarker used to predict prognosis and to select suitable patients for preoperative radiotherapy. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | WD repeat domain containing |
| Description | This gene encodes an essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex required for telomere synthesis. This protein is enriched in Cajal bodies, nuclear sites of RNP processing that are important for telomerase function. It interacts with dyskerin, TERT and TERC, other components of active telomerase, and with small Cajal body RNAs (scaRNAs), which are involved in modifying splicing RNAs. This mRNA also functions as a p53 antisense transcript, that regulates endogenous p53 mRNA levels and further induction of p53 protein by targeting the 5' untranslated region of p53 mRNA. Alternatively spliced transcript variants which differ only in the 5' UTR have been found for this gene. [provided by RefSeq, Mar 2011] | Chromosome | 17 |
| Location | 17p13.1 |
| Start | 7589389 |
| End | 7606820 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 17432 |
| OMIM ID | 612661 |
| HGNC ID | HGNC:25522 |
| Unigene ID | Hs.408312 |
| Ensembl ID | ENSG00000141499 |
| PharmGKB ID | PA164727568 |
Protein Information
| Protein ID | NP_001137462.1 |
|---|---|
| Protein Name | WD repeat containing, antisense to TP53 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 548 |
| Uniprot ID | Q9H161 |
| Ensembl Protein ID | ENSP00000332744 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 491 |
| S | Phosphorylation | 90 |
| T | Phosphorylation | 489;- |
| S | Phosphorylation | 64;- |
| S | Phosphorylation | 26 |
| S | Phosphorylation | 30 |
| S | Phosphorylation | 54 |
| S | Phosphorylation | 85 |
| S | Phosphorylation | 87 |
| S | Phosphorylation | 103 |
| S | Phosphorylation | 112 |
| S | Phosphorylation | 114 |
| S | Phosphorylation | 74 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00200 | 175-480 | WD40 |
| cl02567 | 175-480 | WD40 superfamily |
| cd00200 | 146-441 | WD40 |
| cd00200 | 322-480 | WD40 |
| cd00200 | 143-304 | WD40 |
| cd00200 | 363-483 | WD40 |
| smart00320 | 356-396 | WD40 |
| pfam00400 | 357-396 | WD40 |
| COG2319 | 240-480 | WD40 |
| COG2319 | 137-482 | WD40 |
| COG2319 | 168-480 | WD40 |
| COG2319 | 131-444 | WD40 |
| PLN00181 | 180-491 | PLN00181 |
Ontology Information
| HPRD ID | 16122 |
|---|---|
| Molecular Class | Unclassified |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.