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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
WRN 7486 Werner syndrome, RecQ helicase-like  8RECQL2, RECQ3 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
19945966   2010Cell line : -

Source :

Sample Type : Population-based case-control study

No. of Sample : 1795 CRC and 1805 controls.

Stage : UICC Stage I-IV

GenotypingPolymorhpism-Analyze the associations between polymorphisms in WRN, BLM and RMI1 and CRC risk.


Gene Details



NC_000008.10 (30890778..31031277)

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Gene Type protein coding
Gene Family -
Description This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging. [provided by RefSeq, Jul 2008]  
Chromosome 8
Location 8p12
Start 30890778  
End 31031277  
Strand +  
Gene Sequence

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Length 140500  
OMIM ID 604611   
HGNC ID HGNC:12791   
Unigene ID Hs.632050   
Ensembl ID ENSG00000165392   
PharmGKB ID PA367   

mRNA Information


mRNA ID ?NM_000553.4
Exon complement(<1..454)  
mRNA Sequence

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Length 2699  



CDS Information


   
Location 934..1902
CDS Sequence

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CCDS ID CCDS6082.1



Protein Information


      
Protein IDNP_000544.2
Protein NameWerner syndrome, RecQ helicase-like
Molecular Wt. (Da)54157
Protein Sequence

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Length 1432  
Uniprot IDQ99967
Ensembl Protein ID ENSP00000356623  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation1141
SPhosphorylation1292
SPhosphorylation1058;-
SPhosphorylation1400
SPhosphorylation1133
SPhosphorylation426
SPhosphorylation440
YPhosphorylation1112
SPhosphorylation1120

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                                    
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
142PARP11435NP_001609.2in vivo14734561   
641BLM5211NP_000048.1in vitro;in vivo11919194   
2237FEN12670NP_004102.1in vitro;in vivo123   563   231   159   802   000   000   000   
2547XRCC61071NP_001460.1in vitro;in vivo121   773   001   078   316   000   000   000   
3014H2AFX3465NP_002096.1in vitro;in vivo15733840   
5111PCNA1456NP_002583.1in vitro;in vivo1   087   137   312   633   930   
5425POLD215982NP_006221.1in vitro11027336   
5575PRKAR1B1485NP_002726.1in vitro;in vivo;yeast 2-hybrid12067711   
5591PRKDC2941NP_008835.5in vitro;in vivo11889123   
6117RPA11565NP_002936.1in vitro;in vivo1   037   343   815   735   000   
7014TERF23610NP_005643.1in vitro;in vivo12181313   
7157TP531859NP_000537.3in vitro;in vivo11   427   532   120   800   600   000   000   000   000   000   


Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd0612961-229  RNaseD_like
cl1001261-229  DnaQ_like_exo superfamily
cd00079759-867  HELICc
cl21455759-867  P-loop_NTPase superfamily
cd00046565-705  DEXDc
cl21455565-705  P-loop_NTPase superfamily
cd0901878-229  DEDDy_polA_RNaseD_like_exo
cd0614161-228  WRN_exo
pfam0161261-228  DNA_pol_A_exo1
smart0047461-228  35EXOc
cd0614671-228  mut-7_like_exo
pfam00270551-712  DEAD
smart00956958-1051  RQC
cl09632958-1051  RQC superfamily
smart00490778-859  HELICc
pfam09382958-1051  RQC
pfam00271783-859  Helicase_C
smart003411156-1229  HRDC
cl025781156-1229  HRDC superfamily
pfam144931257-1352  HTH_40
cl236601257-1352  HTH_40 superfamily
cd0614273-216  RNaseD_exo
pfam005701153-1219  HRDC
cd0614877-217  Egl_like_exo
TIGR00614538-1010  recQ_fam
COG0514538-1219  RecQ
TIGR01389540-1220  recQ
PRK11057535-1220  PRK11057
PLN03137541-1107  PLN03137
smart00487543-740  DEXDc
COG0513541-859  SrmB
COG1202545-859  COG1202
COG1205561-862  YprA
COG034995-216  Rnd
PLN00206551-859  PLN00206
COG1201766-857  Lhr
PTZ00424768-883  PTZ00424
PTZ00341156-480  PTZ00341
TIGR03817767-878  DECH_helic
PRK11192767-859  PRK11192
PTZ00110737-887  PTZ00110
PRK09751793-856  PRK09751
COG1061551-857  SSL2
PRK11634767-859  PRK11634
PTZ00341329-501  PTZ00341
PRK01297798-861  PRK01297
TIGR04121794-856  DEXH_lig_assoc
PRK05755124-228  PRK05755
TIGR01388173-249  rnd


Ontology Information


   
HPRD ID5586
Molecular ClassDeoxyribonuclease
Molecular FunctionMolecular function unknown (GO:0005554)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO