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General Information
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21896989 | 2010 | Cell line : - Source : - Sample Type : CRC tumor No. of Sample : 157 Stage : - | Immunohistochemistry | Up-regulation | - | WT1 expression is a marker of poor prognosis in CRCs, independent of AJCC staging. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Zinc fingers, C2H2-type |
| Description | This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilms tumor. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation codon upstream of, and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated. [provided by RefSeq, Mar 2015] | Chromosome | 11 |
| Location | 11p13 |
| Start | 32408789 |
| End | 32457104 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 48316 |
| OMIM ID | 607102 |
| HGNC ID | HGNC:12796 |
| Unigene ID | Hs.591980 |
| Ensembl ID | ENSG00000184937 |
| PharmGKB ID | PA37395 |
mRNA Information
| mRNA ID | ?NM_000378.4 |
|---|---|
| Exon | join(1..836,6917..7039,7478..7580,17882..17959, 35492..35588,39129..39279,42781..42870,43472..43555, 46357..47761) | mRNA Sequence | Download Select all |
| Length | 2977 |
Protein Information
| Protein ID | NP_000369.3 |
|---|---|
| Protein Name | Wilms tumor 1 |
| Molecular Wt. (Da) | 91709 |
| Protein Sequence | Download Select all |
| Length | 449 |
| Uniprot ID | O00478 |
| Ensembl Protein ID | ENSP00000244519 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 433 |
| S | Phosphorylation | 461 |
| S | Phosphorylation | 416 |
| S | Phosphorylation | 444 |
| S | Phosphorylation | 433 |
| S | Phosphorylation | 461 |
| S | Phosphorylation | 416 |
| S | Phosphorylation | 444 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 374 | AREG | 93 | NP_001648.1 | in vitro;in vivo | 10490105 |
| 1387 | CREBBP | 2534 | NP_004371.2 | in vitro;in vivo | 11278547 |
| 2274 | FHL2 | 4026 | NP_001441.4 | in vitro;in vivo | 12151099 |
| 5076 | PAX2 | 1330 | NP_003981.2 | in vitro;in vivo | 14603255 |
| 7157 | TP53 | 1859 | NP_000537.3 | in vivo | 838 946 810 744 705 |
| 7161 | TP73 | 3587 | NP_005418.1 | in vivo | 10744705 |
| 8626 | TP63 | 4469 | NP_003713.3 | in vitro;in vivo | 10744705 |
| 11338 | U2AF2 | 1872 | NP_009210.1 | in vitro;in vivo;yeast 2-hybrid | 9784496 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Transcriptional misregulation in cancer | hsa05202 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam02165 | 1-321 | WT1 |
| cl03474 | 1-321 | WT1 superfamily |
| pfam13465 | 370-394 | zf-H2C2_2 |
| cl22375 | 370-394 | zf-H2C2_2 superfamily |
| pfam13465 | 339-366 | zf-H2C2_2 |
| cl22375 | 339-366 | zf-H2C2_2 superfamily |
| pfam00096 | 383-405 | zf-C2H2 |
| cl23491 | 383-405 | zf-C2H2 superfamily |
| COG5048 | 313-441 | COG5048 |
| COG5048 | 381-442 | COG5048 |
| COG5048 | 381-438 | COG5048 |
| COG5048 | 313-441 | COG5048 |
| COG5048 | 318-403 | COG5048 |
| COG5048 | 328-441 | COG5048 |
| COG5189 | 317-406 | SFP1 |
Ontology Information
| HPRD ID | 1503 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | Receptor signaling complex scaffold activity (GO:0030159) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.