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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20089989 | 2010 | Cell line : - Source : VU University Medical Center, Amsterdam, The Netherlands. Sample Type : CRC tumor and normal tissue No. of Sample : - Stage : TNM Stage II | Biochemical isolation to nano-LC-MS/MS analysis | Unknown | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The Wilms tumor suppressor gene WT1 appears to play a role in both transcriptional and posttranscriptional regulation of certain cellular genes. This gene encodes a WT1-associating protein, which is a ubiquitously expressed nuclear protein. Like WT1 protein, this protein is localized throughout the nucleoplasm as well as in speckles and partially colocalizes with splicing factors. Alternative splicing of this gene results in several transcript variants encoding three different isoforms. [provided by RefSeq, Jul 2012] | Chromosome | 6 |
| Location | 6q25-q27 |
| Start | 159726998 |
| End | 159756319 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 29322 |
| OMIM ID | 605442 |
| HGNC ID | HGNC:16846 |
| Unigene ID | Hs.446091 |
| Ensembl ID | ENSG00000146457 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_004906.4 |
|---|---|
| Exon | join(1..336,9261..9298,11993..12048,15091..15149, 16668..16795,21194..21372,26463..26617,28031..29322) | mRNA Sequence | Download Select all |
| Length | 2265 |
CDS Information
| Location | join(9269..9298,11993..12048,15091..15149,16668..16795, 21194..21372,26463..26617,28031..28614) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS5266.1 |
Protein Information
| Protein ID | NP_001257460.1 |
|---|---|
| Protein Name | Wilms tumor 1 associated protein |
| Molecular Wt. (Da) | 44113 |
| Protein Sequence | Download Select all |
| Length | 396 |
| Uniprot ID | P29320 |
| Ensembl Protein ID | ENSP00000337451 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 244;- |
| S | Phosphorylation | 305;- |
| S | Phosphorylation | 306;- |
| S | Phosphorylation | 288;- |
| S | Phosphorylation | 341 |
| T | Acetylation | 2 |
| T | Acetylation | 2 |
| T | Acetylation | 2 |
| T | Phosphorylation | 343 |
| S | Phosphorylation | 348 |
| T | Phosphorylation | 2 |
| T | Phosphorylation | 2 |
| T | Phosphorylation | 2 |
| T | Phosphorylation | 298 |
| S | Phosphorylation | 388 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 7490 | WT1 | 6163 | NP_077744.3 | in vitro;in vivo;yeast 2-hybrid | 11001926 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| TIGR02169 | 23-233 | SMC_prok_A |
| PRK11281 | 60-231 | PRK11281 |
| COG1196 | 15-233 | Smc |
| COG1196 | 25-233 | Smc |
| COG1196 | 31-232 | Smc |
| TIGR02168 | 24-233 | SMC_prok_B |
| pfam06785 | 28-227 | UPF0242 |
| TIGR02168 | 31-233 | SMC_prok_B |
| COG1196 | 55-231 | Smc |
| TIGR02169 | 12-231 | SMC_prok_A |
Ontology Information
| HPRD ID | 2790 |
|---|---|
| Molecular Class | Unclassified |
| Molecular Function | Transmembrane receptor protein tyrosine kinase activity (GO:0004714) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.