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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
WWOX 51741 WW domain containing oxidoreductase  16FOR, WOX1, SDR41C1 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
21347750   2011Cell line : HCT116, SW480, SW620, HT-29, MDA-MB-231, MCF-7

Source : Oncology Clinic, Medical University

Sample Type : CRC tumor

No. of Sample : 99

Stage : Duke Stage A-D

real time RT-PCR, Methyl Screen method and analysis of loss of heterozygosity statusUp-regulation--


Gene Details



NC_000016.9 (78133310..79246567)

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Gene Type protein coding
Gene Family Short chain dehydrogenase/reductase superfamily / Classical SDR fold cluster 2
Description This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) protein family. This gene spans the FRA16D common chromosomal fragile site and appears to function as a tumor suppressor gene. Expression of the encoded protein is able to induce apoptosis, while defects in this gene are associated with multiple types of cancer. Disruption of this gene is also associated with autosomal recessive spinocerebellar ataxia 12. Disruption of a similar gene in mouse results in impaired steroidogenesis, additionally suggesting a metabolic function for the protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]  
Chromosome 16
Location 16q23.3-q2
Start 78133310  
End 79246567  
Strand +  
Gene Sequence

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Length 1113258  
OMIM ID 605131   
HGNC ID HGNC:12799   
Unigene ID Hs.461453   
Ensembl ID ENSG00000186153   
PharmGKB ID PA37398   

mRNA Information


mRNA ID ?NM_001291997.1
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS42196.1



Protein Information


      
Protein IDNP_001278926.1
Protein NameWW domain containing oxidoreductase
Molecular Wt. (Da)0
Protein Sequence

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Length 414  
Uniprot IDQ9UN36
Ensembl Protein ID ENSP00000298684  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation14
SPhosphorylation14
SPhosphorylation14
YPhosphorylation33
YPhosphorylation33
YPhosphorylation33
YPhosphorylation33
YPhosphorylation33
YPhosphorylation33

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                          
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
5599MAPK83100NP_620637.1in vivo;yeast 2-hybrid12514174   
7157TP531859NP_000537.3in vivo;yeast 2-hybrid11   058   590   155   803   100   000   000   000   000   000   
7161TP733587NP_005418.1in vitro;in vivo15070730   
7314UBB6771NP_061828.1in vivo16288044   
7430EZR475NP_003370.2in vitro;in vivo16438931   
10188TNK26104NP_001010938.1in vivo16288044   


Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd09809124-407  human_WWOX_like_SDR_c-like
cl21454124-407  NADB_Rossmann superfamily
cd0020119-47  WW
cl0015719-47  WW superfamily
cd0020160-90  WW
cl0015760-90  WW superfamily
cd05327124-398  retinol-DH_like_SDR_c_like
cd09807124-401  retinol-DH_like_SDR_c
cd09810125-405  LPOR_like_SDR_c_like
PRK05854120-404  PRK05854
PLN00015128-405  PLN00015
PRK07453127-405  PRK07453
TIGR01289127-405  LPOR
cd05233127-324  SDR_c
cd05324125-377  carb_red_PTCR-like_SDR_c
cd09808124-363  DHRS-12_like_SDR_c-like
cd08941125-363  3KS_SDR_c
cd05325127-324  carb_red_sniffer_like_SDR_c
cd05332122-260  11beta-HSD1_like_SDR_c
cd08932125-324  HetN_like_SDR_c
cd08939124-326  KDSR-like_SDR_c
cd05333125-324  BKR_SDR_c
cd05344124-324  BKR_like_SDR_like
cd05354122-324  SDR_c7
cd05369122-241  TER_DECR_SDR_a
cd05370121-260  SDR_c2
cd05374125-260  17beta-HSD-like_SDR_c
cd08951127-409  DR_C-13_KR_SDR_c_like
cd05331127-324  DH-DHB-DH_SDR_c
cd08942121-324  RhlG_SDR_c
cd05360126-261  SDR_c3
cd05351121-264  XR_like_SDR_c
cd05339126-263  17beta-HSDXI-like_SDR_c
cd05362123-326  THN_reductase-like_SDR_c
cd08935121-324  mannonate_red_SDR_c
cd05323125-324  ADH_SDR_c_like
cd05329124-260  TR_SDR_c
cd05345124-323  BKR_3_SDR_c
cd05364122-333  SDR_c11
cd05347121-260  Ga5DH-like_SDR_c
cd05359127-324  ChcA_like_SDR_c
PRK08945124-260  PRK08945
cd05352121-363  MDH-like_SDR_c
cd05358123-336  GlcDH_SDR_c
PRK08703122-324  PRK08703
PRK07806121-212  PRK07806
cd08934123-324  CAD_SDR_c
cd05340124-324  Ycik_SDR_c
cd05346125-243  SDR_c5
cd08944122-231  SDR_c12
smart0045618-47  WW
cd08945125-324  PKR_SDR_c
PRK07523121-211  PRK07523
cd0535595-324  SDR_c1
cd09805125-325  type2_17beta_HSD-like_SDR_c
cd05365126-327  7_alpha_HSDH_SDR_c
pfam0039718-47  WW
cd05366124-335  meso-BDH-like_SDR_c
PRK06947125-334  PRK06947
cd08943124-241  R1PA_ADH_SDR_c
cd05350127-260  SDR_c6
cd05357125-324  PR_SDR_c
cd05338124-324  DHRS1_HSDL2-like_SDR_c
cd08940124-211  HBDH_SDR_c
cd09806125-260  type1_17beta-HSD-like_SDR_c
cd05328126-324  3alpha_HSD_SDR_c
PRK12746120-324  PRK12746
PRK08017125-260  PRK08017
cd08929125-324  SDR_c4
cd05363124-324  SDH_SDR_c
cd05274127-260  KR_FAS_SDR_x
cd08930123-212  SDR_c8
smart0045658-90  WW
cd08936123-336  CR_SDR_c
PRK06550121-152  fabG
smart00822125-251  PKS_KR
PRK09730125-334  PRK09730
cd08937122-211  DHB_DH-like_SDR_c
PRK12935124-324  PRK12935
PRK08085124-211  PRK08085
cd05368123-324  DHRS6_like_SDR_c
cd05343122-232  Mgc4172-like_SDR_c
PRK06123125-334  PRK06123
pfam13561134-229  adh_short_C2
cd05341121-324  3beta-17beta-HSD_like_SDR_c
cd05326124-324  secoisolariciresinol-DH_like_SDR_c
cd05349125-324  BKR_2_SDR_c
PRK07832125-235  PRK07832
cd05348123-237  BphB-like_SDR_c
cd05356124-211  17beta-HSD1_like_SDR_c
pfam0039759-88  WW
cd05337126-324  BKR_1_SDR_c
cd02266127-325  SDR
cd05367126-260  SPR-like_SDR_c
PRK07069129-323  PRK07069
cd05373126-215  SDR_c10
cd09761124-264  A3DFK9-like_SDR_c
cd05353121-152  hydroxyacyl-CoA-like_DH_SDR_c-like
pfam08659126-205  KR
PRK05876122-198  PRK05876
PRK05993125-260  PRK05993
cd01078117-217  NAD_bind_H4MPT_DH
PRK08339121-171  PRK08339
PRK08251123-183  PRK08251
cd08928127-387  KR_fFAS_like_SDR_c_like
cd08953123-265  KR_2_SDR_x
cd05372124-230  ENR_SDR
cd05371123-252  HSD10-like_SDR_c
PRK07102124-208  PRK07102
cd05330122-260  cyclohexanol_reductase_SDR_c
PRK12747124-324  PRK12747
cd11731127-247  Lin1944_like_SDR_c
cd08933119-169  RDH_SDR_c
cd08270111-161  MDR4
cl16912111-161  MDR superfamily
PRK06101126-182  PRK06101
PRK06196107-404  PRK06196
PRK06197121-404  PRK06197
COG1028121-348  FabG
PRK12826120-325  PRK12826
PRK05653121-325  fabG
PRK07231120-324  fabG
COG0300121-324  DltE
COG4221123-324  YdfG
PRK06500122-324  PRK06500
PRK12825124-326  fabG
pfam00106125-260  adh_short
PRK12829120-325  PRK12829
PRK12828121-327  PRK12828
PRK12939123-324  PRK12939
PRK07063124-232  PRK07063
PRK05557121-324  fabG
PRK07062121-260  PRK07062
PRK07067124-264  PRK07067
PRK06124114-324  PRK06124
PRK08220121-324  PRK08220
PRK08324122-241  PRK08324
TIGR01830127-324  3oxo_ACP_reduc
PRK06125121-211  PRK06125
PRK06841111-323  PRK06841
PRK12384123-329  PRK12384
COG3967122-260  DltE
TIGR04316127-324  dhbA_paeA
PRK07035121-241  PRK07035
PRK07825120-211  PRK07825
PRK05866118-212  PRK05866
PRK05855120-211  PRK05855
PRK08264121-326  PRK08264
PRK07109117-238  PRK07109
TIGR02632120-337  RhaD_aldol-ADH
PRK05565121-327  fabG
PRK06181124-260  PRK06181
PRK07201124-240  PRK07201
PRK07576121-212  PRK07576
PRK07060121-324  PRK07060
PRK12429123-211  PRK12429
PRK06484124-324  PRK06484
PRK09242124-262  PRK09242
PRK08213113-324  PRK08213
PRK07831124-211  PRK07831
PRK06914124-324  PRK06914
TIGR01963124-211  PHB_DH
PRK07890122-326  PRK07890
PRK08277121-262  PRK08277
PRK0670196-324  PRK06701
PRK12827124-337  PRK12827
PRK08589125-213  PRK08589
PRK08226123-327  PRK08226
PRK07666119-238  fabG
PRK06198121-262  PRK06198
PRK06194121-242  PRK06194
PRK12824125-324  PRK12824
PRK06139124-211  PRK06139
PRK07478124-171  PRK07478
PRK07326122-324  PRK07326
PRK12823122-210  benD
PRK05872124-324  PRK05872
PRK06138121-211  PRK06138
PRK06949121-241  PRK06949
PRK07774121-214  PRK07774
PRK07677124-212  PRK07677
PRK06523120-373  PRK06523
PRK08261124-211  fabG
PRK07454125-211  PRK07454
PRK12742121-324  PRK12742
PRK08063122-324  PRK08063
PRK08217121-225  fabG
PRK12748123-324  PRK12748
PRK12937123-324  PRK12937
PRK07775127-324  PRK07775
PRK06172121-170  PRK06172
PRK05867121-347  PRK05867
PRK09072124-260  PRK09072
PRK12936121-324  PRK12936
PRK07041128-213  PRK07041
TIGR03206124-324  benzo_BadH
PRK06113124-324  PRK06113
PRK06179125-211  PRK06179
TIGR02415125-324  23BDH
PRK08643123-329  PRK08643
PRK07814116-329  PRK07814
PRK06484110-324  PRK06484
PRK08265124-324  PRK08265
PRK12745125-269  PRK12745
TIGR03971122-325  SDR_subfam_1
PRK06200123-263  PRK06200
PRK07074123-259  PRK07074
PRK07097121-211  PRK07097
PRK06057117-154  PRK06057
TIGR01832121-211  kduD
PRK06182125-266  PRK06182
PRK0612882-324  PRK06128
TIGR01829125-324  AcAcCoA_reduct
PRK07791114-262  PRK07791
PRK07577125-347  PRK07577
PRK07856121-262  PRK07856
PRK09135124-214  PRK09135
PRK06935121-213  PRK06935
COG0451125-327  WcaG
PRK07985119-324  PRK07985
PRK09186123-240  PRK09186
PRK09291123-336  PRK09291
PRK13394121-211  PRK13394
PRK12743125-260  PRK12743
TIGR04504124-326  SDR_subfam_2
PRK05875122-324  PRK05875
PRK06463122-324  fabG
PRK08219125-260  PRK08219
PRK08936120-211  PRK08936
PRK06077121-247  fabG
PRK05786122-327  fabG
PRK07792119-262  fabG
PRK05650127-324  PRK05650
pfam13460127-259  NAD_binding_10
PRK08263123-260  PRK08263
PRK08642125-211  fabG
PRK06398120-152  PRK06398
PRK08278121-154  PRK08278
PRK06180123-211  PRK06180
PRK07024127-211  PRK07024
PRK06114121-324  PRK06114
PRK05693125-324  PRK05693
PRK06171121-154  PRK06171
TIGR03325123-260  BphB_TodD
PRK08628124-184  PRK08628
COG5021Aug-90  HUL4


Ontology Information


   
HPRD ID9469
Molecular ClassEnzyme: Oxidoreductase
Molecular FunctionAuxiliary transport protein activity (GO:0015457)
Biological ProcessTransport (GO:0006810)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO