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General Information
- Evidence
- Gene
- mRNA
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- Protein
- PTM
- Enzyme
- PPi
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- Domain
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23015401 | 2012 | Cell line : - Source : - Sample Type : CRC Tumor and adjescent tissue No. of Sample : 66 CRC patients. Stage : - | Immunohistochemistry | Up-regulation | - | p63 is a potential prognostic factor for CRC. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Exportins |
| Description | This gene encodes a member of the karyopherin family that is required for the transport of small RNAs and double-stranded RNA-binding proteins from the nucleus to the cytoplasm. The encoded protein translocates cargo through the nuclear pore complex in a RanGTP-dependent process. [provided by RefSeq, Aug 2011] | Chromosome | 6 |
| Location | 6p21.1 |
| Start | 43490068 |
| End | 43543812 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 53745 |
| OMIM ID | 607845 |
| HGNC ID | HGNC:17675 |
| Unigene ID | Hs.203206 |
| Ensembl ID | ENSG00000124571 |
| PharmGKB ID | PA134979214 |
Protein Information
| Protein ID | NP_065801.1 |
|---|---|
| Protein Name | exportin 5 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 1204 |
| Uniprot ID | Q99944 |
| Ensembl Protein ID | ENSP00000333380 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 826 |
| K | Acetylation | 396 |
| S | Phosphorylation | 1137 |
| S | Phosphorylation | 722 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1915 | EEF1A1 | 559 | NP_001393.1 | in vitro | 12426393 |
| 5901 | RAN | 3109 | NP_006316.1 | in vitro;in vivo;yeast 2-hybrid | 11777942 |
| 8021 | NUP214 | 258 | NP_005076.3 | in vitro;in vivo;yeast 2-hybrid | 11777942 |
| 8772 | FADD | 3909 | NP_003815.1 | in vitro;in vivo;yeast 2-hybrid | 12702765 |
| 9972 | NUP153 | 4899 | NP_005115.2 | in vitro;in vivo;yeast 2-hybrid | 11777942 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| RNA transport | hsa03013 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam08389 | 109-248 | Xpo1 |
| cl07129 | 109-248 | Xpo1 superfamily |
| smart00913 | 33-100 | IBN_N |
| cl04271 | 33-100 | IBN_N superfamily |
| COG5101 | 64-353 | CRM1 |
Ontology Information
| HPRD ID | 6900 |
|---|---|
| Molecular Class | Transport/cargo protein |
| Molecular Function | DNA binding (GO:0003677) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.