Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| XRCC2 | 7516 | X-ray repair complementing defective repair in Chinese hamster cells 2 | 7 | - |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25304007 | 2014 | Cell line : - Source : - Sample Type : Hospital-based case-control study No. of Sample : 246 CRC cases and 262 healthy controls Stage : - | PCR-RFLP,immunohistochemistry | Polymorhpism | - | XRCC2 C41657T polymorphism may adjust the XRCC2 expression and might influence susceptibility of CRC. |
| 25526472 | 2014 | Cell line : SW480 Source : - Sample Type : CRC Tumor and normal tissue No. of Sample : 153 Stage : - | Immunohistochemistry | Up-regulation | - | XRCC2 overexpression inhibited CRC cell apoptosis and promoted proliferation by enriching cells in the G0/G1 phase. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene is involved in the repair of DNA double-strand breaks by homologous recombination and it functionally complements Chinese hamster irs1, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents. [provided by RefSeq, Jul 2008] | Chromosome | 7 |
| Location | 7q36 |
| Start | 152343583 |
| End | 152373250 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 29668 |
| OMIM ID | 600375 |
| HGNC ID | HGNC:12829 |
| Unigene ID | Hs.647093 |
| Ensembl ID | ENSG00000196584 |
| PharmGKB ID | PA37421 |
mRNA Information
| mRNA ID | ?NM_005431.1 |
|---|---|
| Exon | join(1..125,15384..15465,26803..29668) | mRNA Sequence | Download Select all |
| Length | 3094 |
Protein Information
| Protein ID | NP_005422.1 |
|---|---|
| Protein Name | X-ray repair complementing defective repair in Chinese hamster cells 2 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 280 |
| Uniprot ID | Q9Y6X2 |
| Ensembl Protein ID | ENSP00000376765 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 249;- |
| S | Phosphorylation | 247;- |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Homologous recombination | hsa03440 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd01123 | 41-196 | Rad51_DMC1_radA |
| cl21455 | 41-196 | P-loop_NTPase superfamily |
| cd01393 | 41-196 | recA_like |
| cd01120 | 43-197 | RecA-like_NTPases |
| cd01394 | 41-155 | radB |
| pfam08423 | 41-206 | Rad51 |
| TIGR02236 | 9-196 | recomb_radA |
| COG0468 | 41-201 | RecA |
| PTZ00035 | 41-206 | PTZ00035 |
| TIGR02239 | 41-200 | recomb_RAD51 |
| PLN03186 | 41-200 | PLN03186 |
| PRK04301 | 43-196 | radA |
| TIGR02238 | 43-198 | recomb_DMC1 |
| PLN03187 | 43-198 | PLN03187 |
| TIGR02237 | 41-169 | recomb_radB |
Ontology Information
| HPRD ID | 9424 |
|---|---|
| Molecular Class | DNA binding protein |
| Molecular Function | Transcription regulator activity (GO:0030528) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.