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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| YAP1 | 10413 | Yes-associated protein 1, 65kDa | 11 | YAP; YKI; YAP2; YAP65 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 18703216 | 2008 | Cell line : - Source : Pathology department at The Johns Hopkins Hospital in Baltimore, Maryland. Sample Type : CRC tumor and normal tissue No. of Sample : - Stage : - | Tissue Microarray, Immunohistochemistry | Up-regulation | - | YAP may be a component of an oncogenic pathway that is present in three common histological tumor types. Given the widespread expression of the nuclear effector YAP, it is likely that this pathway is commonly altered in the process of carcinogenesis. Therefore, this pathway could be a potential therapeutic target for the three common malignant tumor types (colonic adenocarcinoma, lung adenocarcinoma, and OSC) which demonstrated higher YAP expression compared to their respective normal tissues. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes the human ortholog of chicken YAP protein which binds to the SH3 domain of the Yes proto-oncogene product. This protein contains a WW domain that is found in various structural, regulatory and signaling molecules in yeast, nematode, and mammals, and may be involved in protein-protein interaction. [provided by RefSeq, Jul 2008] | Chromosome | 11 |
| Location | 11q13 |
| Start | 102110254 |
| End | 102233423 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 123170 |
| OMIM ID | 606608 |
| HGNC ID | HGNC:16262 |
| Unigene ID | Hs.503692 |
| Ensembl ID | ENSG00000137693 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | XM_005271378.2 |
|---|---|
| Exon | join(1..916,3891..4141,52203..52318,75765..75884, 95640..95833,99264..99311,113369..113499,117216..117328, 119449..123169) | mRNA Sequence | Download Select all |
| Length | 5610 |
CDS Information
| Location | join(596..916,3891..4141,52203..52318,75765..75884, 95640..95833,99264..99311,113369..113499,117216..117328, 119449..119687) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | - |
Protein Information
| Protein ID | NP_001123617.1 |
|---|---|
| Protein Name | Yes-associated protein 1, 65kDa |
| Molecular Wt. (Da) | 54331 |
| Protein Sequence | Download Select all |
| Length | 504 |
| Uniprot ID | P21860 |
| Ensembl Protein ID | ENSP00000267101 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 347 |
| T | Phosphorylation | 348 |
| S | Phosphorylation | 127 |
| S | Phosphorylation | 109 |
| T | Phosphorylation | 110 |
| Y | Phosphorylation | 357 |
| S | Phosphorylation | 109;- |
| S | Phosphorylation | 321;- |
| S | Phosphorylation | 131;- |
| T | Phosphorylation | 143;- |
| T | Phosphorylation | 154;- |
| S | Phosphorylation | 164;- |
| S | Phosphorylation | 61 |
| T | Phosphorylation | 63 |
| S | Phosphorylation | 128 |
| S | Phosphorylation | 149 |
| S | Phosphorylation | 138 |
| T | Phosphorylation | 156 |
| S | Phosphorylation | 163 |
| S | Phosphorylation | 236 |
| S | Phosphorylation | 251 |
| S | Phosphorylation | 260 |
| S | Phosphorylation | 317 |
| S | Phosphorylation | 331 |
| S | Phosphorylation | 353 |
| T | Phosphorylation | 114 |
| S | Phosphorylation | 238 |
| S | Phosphorylation | 217 |
| T | Phosphorylation | 119 |
| T | Phosphorylation | 145 |
| S | Phosphorylation | 105 |
| T | Phosphorylation | 141 |
| S | Phosphorylation | 350 |
| S | Phosphorylation | 355 |
| S | Phosphorylation | 356 |
| S | Phosphorylation | 358 |
| S | Phosphorylation | 103 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 860 | RUNX2 | 2566 | NP_001019801.3 | in vitro;yeast 2-hybrid | 10228168 |
| 861 | RUNX1 | 1043 | NP_001745.2 | in vitro;in vivo;yeast 2-hybrid | 10228168 |
| 2066 | ERBB4 | 2767 | NP_005226.1 | in vitro;in vivo;yeast 2-hybrid | 15023535 |
| 3192 | HNRNPU | 4185 | NP_114032.2 | in vitro;in vivo | 15096513 |
| 4092 | SMAD7 | 4241 | NP_005895.1 | in vitro;in vivo;yeast 2-hybrid | 12118366 |
| 7003 | TEAD1 | 1802 | NP_068780.1 | in vitro;in vivo | 11358867 |
| 7004 | TEAD4 | 3421 | NP_003204.2 | in vitro;in vivo | 11358867 |
| 7005 | TEAD3 | 4411 | NP_003205.2 | in vitro;in vivo | 11358867 |
| 7161 | TP73 | 3587 | NP_005418.1 | in vitro;in vivo | 1 127 868 518 280 240 |
| 7532 | YWHAG | 5639 | NP_036611.2 | in vivo | 15324660 |
| 8463 | TEAD2 | 3432 | AAH51301.1 | in vitro;in vivo | 11358867 |
| 9368 | SLC9A3R1 | 5406 | NP_004243.1 | in vitro;in vivo | 10562288 |
| 10971 | YWHAQ | 886 | NP_006817.1 | in vitro;in vivo | 12535517 |
| 23558 | WBP2 | 6097 | NP_036610.2 | in vitro | 7644498 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Hippo signaling pathway | hsa04390 |
Structure Information
| PDB ID | 1JMQ |
|---|---|
| Resolution | - |
| Method | solution NMR |
| Chains | A |
| Molecule | 65 KDA YES-ASSOCIATED PROTEIN |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00201 | 233-263 | WW |
| cl00157 | 233-263 | WW superfamily |
| cd00201 | 174-203 | WW |
| cl00157 | 174-203 | WW superfamily |
| smart00456 | 231-263 | WW |
| smart00456 | 172-203 | WW |
| pfam00397 | 232-261 | WW |
| pfam00397 | 173-202 | WW |
| COG5021 | 173-271 | HUL4 |
| COG5104 | 177-261 | PRP40 |
| pfam15238 | 61-121 | FAM181 |
Ontology Information
| HPRD ID | 3638 |
|---|---|
| Molecular Class | Transcription regulatory protein |
| Molecular Function | Growth factor activity (GO:0008083) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.