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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| YEATS4 | 8089 | YEATS domain containing 4 | 12 | NuBI-1, GAS41, YAF9 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 26045900 | 2015 | Cell line : RKO Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 85 Stage : - | Flow cytometry,cell proliferation and colony formation assay. | Up-regulation | - | YEATS4 may be an important regulator of cell proliferation and apoptosis in CRC cells. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene is found in the nucleoli. It has high sequence homology to human MLLT1, and yeast and human MLLT3 proteins. Both MLLT1 and MLLT3 proteins belong to a class of transcription factors, indicating that the encoded protein might also represent a transcription factor. This protein is thought to be required for RNA transcription. This gene has been shown to be amplified in tumors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014] | Chromosome | 12 |
| Location | 12q13-q15 |
| Start | 69753490 |
| End | 69784576 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 31087 |
| OMIM ID | 602116 |
| HGNC ID | HGNC:24859 |
| Unigene ID | Hs.4029 |
| Ensembl ID | - |
| PharmGKB ID | PA134992686 |
mRNA Information
| mRNA ID | ?NM_001300950.1 |
|---|---|
| Exon | join(11..324,3089..3208,5934..6000,6091..6185, 11007..11099,11189..11276,30448..31171) | mRNA Sequence | Download Select all |
| Length | 1509 |
Protein Information
| Protein ID | NP_001287879.1 |
|---|---|
| Protein Name | YEATS domain containing 4 |
| Molecular Wt. (Da) | 12234 |
| Protein Sequence | Download Select all |
| Length | 227 |
| Uniprot ID | O95994 |
| Ensembl Protein ID | ENSP00000391490 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 123 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 4926 | NUMA1 | 1236 | CAA77669.1 | in vitro;in vivo;yeast 2-hybrid | 10913114 |
| 6598 | SMARCB1 | 3364 | NP_003064.2 | in vitro;in vivo | 11756182 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam03366 | 44-126 | YEATS |
| cl19881 | 44-126 | YEATS superfamily |
| COG5033 | 15-199 | TFG3 |
Ontology Information
| HPRD ID | 9163 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | Guanyl-nucleotide exchange factor activity (GO:0005085) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.