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General Information
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25031734 | 2014 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 30 fresh primary CRC tumor tissues and corresponding normal tissues and 120 paraffin-embedded primary CRC tumor tissues and corresponding normal tissues Stage : Duke Stag A-D | real time RT-PCR,Multivariate analysis, Western blotting, immunohistochemistry | Up-regulation | - | Multivariate analysis suggested that high expression of ZFX was an independent prognostic factor for CRC patients. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Zinc fingers, C2H2-type |
| Description | This gene on the X chromosome is structurally similar to a related gene on the Y chromosome. It encodes a member of the krueppel C2H2-type zinc-finger protein family. The full-length protein contains an acidic transcriptional activation domain (AD), a nuclear localization sequence (NLS) and a DNA binding domain (DBD) consisting of 13 C2H2-type zinc fingers. Studies in mouse embryonic and adult hematopoietic stem cells showed that this gene was required as a transcriptional regulator for self-renewal of both stem cell types, but it was dispensable for growth and differentiation of their progeny. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2010] | Chromosome | X |
| Location | Xp22.1-p21 |
| Start | 24167047 |
| End | 24234372 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 67326 |
| OMIM ID | 314980 |
| HGNC ID | HGNC:12869 |
| Unigene ID | Hs.336681 |
| Ensembl ID | ENSG00000005889 |
| PharmGKB ID | PA37458 |
mRNA Information
| mRNA ID | ?NM_001178084.1 |
|---|---|
| Exon | join(1..320,23782..23867,30250..30837,58393..58542, 58779..58922,59285..59437,59967..60107,61260..67156) | mRNA Sequence | Download Select all |
| Length | 7479 |
Protein Information
| Protein ID | NP_001171555.1 |
|---|---|
| Protein Name | zinc finger protein, X-linked |
| Molecular Wt. (Da) | 48178 |
| Protein Sequence | Download Select all |
| Length | 805 |
| Uniprot ID | Q9UKW4 |
| Ensembl Protein ID | ENSP00000359073 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 274 |
| T | Phosphorylation | 268 |
| T | Phosphorylation | 714 |
| S | Phosphorylation | 543 |
| T | Phosphorylation | 657 |
| T | Phosphorylation | 771 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam04704 | 69-410 | Zfx_Zfy_act |
| cl04690 | 69-410 | Zfx_Zfy_act superfamily |
| pfam13465 | 562-584 | zf-H2C2_2 |
| cl22375 | 562-584 | zf-H2C2_2 superfamily |
| pfam05443 | 427-447 | ROS_MUCR |
| cl19880 | 427-447 | ROS_MUCR superfamily |
| pfam13465 | 733-757 | zf-H2C2_2 |
| cl22375 | 733-757 | zf-H2C2_2 superfamily |
| COG5048 | 543-805 | COG5048 |
| COG5048 | 511-654 | COG5048 |
| COG5048 | 430-801 | COG5048 |
Ontology Information
| HPRD ID | 7246 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | Protein binding (GO:0005515) |
| Biological Process | Regulation of cell cycle (GO:0000074) |
Drug Information
No matching records could be found.