Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CDH12 | 1010 | cadherin 12, type 2 (N-cadherin 2) | 5 | Br-cadherin, CDHB |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24237488 | 2013 | Cell line : HCT116, HT29, Caco2, LoVo and NCM460 ,SW1116, SW480 and SW620 Source : ATCC Sample Type : - No. of Sample : - Stage : - | Immunohistochemistry, Real-time PCR and Western Blotting, CCK-8 assay, shRNAs, wound assay and transwell assay | Up-regulation | - | CDH12 promotes proliferation, migration, invasion, adhesion and angiogenesis, suggesting that CDH12 may be an oncogene in colorectal cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Cadherins / Major cadherins |
| Description | This gene encodes a type II classical cadherin of the cadherin superfamily. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature cadherin protein. These integral membrane proteins mediate calcium-dependent cell-cell adhesion and are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a histidine-alanine-valine (HAV) cell adhesion recognition sequence specific to type I cadherins. This particular cadherin appears to be expressed specifically in the brain and its temporal pattern of expression would be consistent with a role during a critical period of neuronal development, perhaps specifically during synaptogenesis. [provided by RefSeq, Nov 2015] |
| Chromosome | 5 |
| Location | 5p14.3 |
| Start | 21750870 |
| End | 22853731 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 1102862 |
| OMIM ID | 600562 |
| HGNC ID | HGNC:1751 |
| Unigene ID | Hs.113684 |
| Ensembl ID | ENSG00000154162 |
| PharmGKB ID | PA26285 |
mRNA Information
| mRNA ID | NM_004061.4 |
|---|---|
| Exon | join(1..565,348259..348353,448272..448366,640980..641125, 774761..775177,878238..878532,998833..998952, 1011295..1011462,1036491..1036678,1051203..1051456, 1070129..1070265,1088524..1088645,1092948..1093065, 1097781..1098032,1101387..1102759) | mRNA Sequence | Download Select all |
| Length | 4343 |
Protein Information
| Protein ID | NP_004052.2 |
|---|---|
| Protein Name | cadherin 12, type 2 (N-cadherin 2) |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 794 |
| Uniprot ID | P46531 |
| Ensembl Protein ID | ENSP00000277541 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 286 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1016 | CDH18 | 4314 | NP_004925.1 | in vitro;in vivo | 10861224 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd11304 | 164-265 | Cadherin_repeat |
| cl15786 | 164-265 | CA_like superfamily |
| cd11304 | 273-380 | Cadherin_repeat |
| cl15786 | 273-380 | CA_like superfamily |
| cd11304 | 389-484 | Cadherin_repeat |
| cl15786 | 389-484 | CA_like superfamily |
| cd11304 | 73-156 | Cadherin_repeat |
| cl15786 | 73-156 | CA_like superfamily |
| cd11304 | 492-590 | Cadherin_repeat |
| cl15786 | 492-590 | CA_like superfamily |
| pfam01049 | 638-785 | Cadherin_C |
| cl03079 | 638-785 | Cadherin_C superfamily |
| smart00112 | 183-267 | CA |
| smart00112 | 80-158 | CA |
| pfam00028 | 165-260 | Cadherin |
| smart00112 | 292-382 | CA |
| smart00112 | 407-487 | CA |
| pfam00028 | 274-376 | Cadherin |
| pfam00028 | 389-480 | Cadherin |
| pfam00028 | 68-151 | Cadherin |
| pfam00028 | 493-590 | Cadherin |
| cd00031 | 70-156 | CA_like |
| smart00112 | 511-590 | CA |
Ontology Information
| HPRD ID | 2606 |
|---|---|
| Molecular Class | Adhesion molecule |
| Molecular Function | Receptor activity (GO:0004872) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.