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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
CDH12 1010 cadherin 12, type 2 (N-cadherin 2)  5Br-cadherin, CDHB 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
24237488   2013Cell line : HCT116, HT29, Caco2, LoVo and NCM460 ,SW1116, SW480 and SW620

Source : ATCC

Sample Type : -

No. of Sample : -

Stage : -

Immunohistochemistry, Real-time PCR and Western Blotting, CCK-8 assay, shRNAs, wound assay and transwell assay Up-regulation- CDH12 promotes proliferation, migration, invasion, adhesion and angiogenesis, suggesting that CDH12 may be an oncogene in colorectal cancer.


Gene Details



NC_000005.9 (21750870..22853731, complement)

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Gene Type protein coding
Gene Family Cadherins / Major cadherins
Description This gene encodes a type II classical cadherin of the cadherin superfamily. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature cadherin protein. These integral membrane proteins mediate calcium-dependent cell-cell adhesion and are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a histidine-alanine-valine (HAV) cell adhesion recognition sequence specific to type I cadherins. This particular cadherin appears to be expressed specifically in the brain and its temporal pattern of expression would be consistent with a role during a critical period of neuronal development, perhaps specifically during synaptogenesis. [provided by RefSeq, Nov 2015]  
Chromosome 5
Location 5p14.3
Start 21750870  
End 22853731  
Strand -  
Gene Sequence

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Length 1102862  
OMIM ID 600562   
HGNC ID HGNC:1751   
Unigene ID Hs.113684   
Ensembl ID ENSG00000154162   
PharmGKB ID PA26285   

mRNA Information


mRNA ID NM_004061.4
Exon join(1..565,348259..348353,448272..448366,640980..641125, 774761..775177,878238..878532,998833..998952, 1011295..1011462,1036491..1036678,1051203..1051456, 1070129..1070265,1088524..1088645,1092948..1093065, 1097781..1098032,1101387..1102759)  
mRNA Sequence

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Length 4343  



CDS Information


   
Location 1088..3472
CDS Sequence

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CCDS ID CCDS3890.1



Protein Information


      
Protein IDNP_004052.2
Protein Namecadherin 12, type 2 (N-cadherin 2)
Molecular Wt. (Da)0
Protein Sequence

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Length 794  
Uniprot IDP46531
Ensembl Protein ID ENSP00000277541  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation286

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

               
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
1016CDH184314NP_004925.1in vitro;in vivo10861224   


Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd11304164-265  Cadherin_repeat
cl15786164-265  CA_like superfamily
cd11304273-380  Cadherin_repeat
cl15786273-380  CA_like superfamily
cd11304389-484  Cadherin_repeat
cl15786389-484  CA_like superfamily
cd1130473-156  Cadherin_repeat
cl1578673-156  CA_like superfamily
cd11304492-590  Cadherin_repeat
cl15786492-590  CA_like superfamily
pfam01049638-785  Cadherin_C
cl03079638-785  Cadherin_C superfamily
smart00112183-267  CA
smart0011280-158  CA
pfam00028165-260  Cadherin
smart00112292-382  CA
smart00112407-487  CA
pfam00028274-376  Cadherin
pfam00028389-480  Cadherin
pfam0002868-151  Cadherin
pfam00028493-590  Cadherin
cd0003170-156  CA_like
smart00112511-590  CA


Ontology Information


   
HPRD ID2606
Molecular ClassAdhesion molecule
Molecular FunctionReceptor activity (GO:0004872)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO