Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CDH13 | 1012 | Cadherin 13, H-cadherin (heart) | 16 | CDHH; P105 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 12067979 | 2002 | Cell line : - Source : Dallas, Texas and Baltimore, Maryland. Sample Type : CRA,CRC tumor and Normal tissue No. of Sample : 35 CRC 33 normal tissue and 19 CRA Stage : - | Luciferase assay, Methylation specific -PCR, bisulfite DNA sequencing | Methylation | - | Promoter activity of 5' region of CDH13 show aberrant methylation in colorectal cancers, cell lines, and adenomas. |
| 14997203 | 2004 | Cell line : - Source : Nagoya University School of Medicine from Japanese colorectal cancer patients. Sample Type : CRC tumor and Normal tissue No. of Sample : 84 Stage : TNM stage I-III | Bisulphite modification and methylation-specific PCR, RT-PCR | Methylation | - | Specifically methylation of promoter region of CDH13 express H-cadherin and t-cadherin. Poorly differentiated colorectal cancers specifically exhibited CDH13 methylation, and since CDH13 might be responsible for selective cell recognition and adhesion,inactivation of CDH13 could lead to the formation of scattered carcinoma cells in these cancers. |
| 15793636 | 2005 | Cell line : - Source : - Sample Type : CRC tumor and Normal tissue No. of Sample : 61 Stage : TNM stage I-IV | Msethylation specific- PCR | Methylation | - | Colorectal cancers without lymph node metastasis frequently exhibited the aberrant methylation of HLTF , SOCS-1 , and CDH13 genes |
| 17201142 | 2006 | Cell line : - Source : - Sample Type : CRC tumor and Normal tissue No. of Sample : 58 Stage : TNM stage I-IV | Msethylation specific- PCR | Methylation | - | Poorly-differentiated colorectal cancers preferentially exhibited gene methylation |
| 21796503 | 2012 | Cell line : - Source : - Sample Type : CRC tumor and Normal tissue No. of Sample : 85 Stage : TNM stage I-IV | Msethylation specific- PCR | Methylation | - | Methylation frequencies in cancerous tissues were 31.8% for CDH13 were significantly higher than in corresponding normal tissue. CDH13 methylation was associated with poor differentiation (P=0.019) and tended to be predominant in advanced stages (P=0.084). |
| 22132162 | 2011 | Cell line : - Source : M.D. Anderson Cancer Center (n =64) or at the Showa University Hospital (n =15). Sample Type : CRC tumor and Normal tissue No. of Sample : 79 CRCs, 36 CRCs without liver metastasis (stage I-III) and 43 CRCs with liver metastasis (stage IV/liver recurrence) Stage : TNM stage I-IV | Bisulfite-pyrosequencing for DNA methylation analysis, Methylation, mutation and definition of CIMP, | Methylation | - | DNA methylation changes occur for the most part before progression to liver metastasis. CDH13 have been reported to be altered in primary or metastatic CRCs. |
| 22034905 | 2011 | Cell line : 22 gastric and colorectal cancer cell lines Source : - Sample Type : - No. of Sample : - Stage : - | Exon array, Array-based comparative genomic hybridization, | Mutation | - | Focusing on protein kinase genes and genes belonging to the cadherin-catenin family. The exon array analysis clearly identified a deletional transcript of CDH13. This abnormal transcripts were shown to have arisen from small genomic deletions. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Cadherins / Major cadherins |
| Description | This gene encodes a member of the cadherin superfamily. The encoded protein is localized to the surface of the cell membrane and is anchored by a GPI moiety, rather than by a transmembrane domain. The protein lacks the cytoplasmic domain characteristic of other cadherins, and so is not thought to be a cell-cell adhesion glycoprotein. This protein acts as a negative regulator of axon growth during neural differentiation. It also protects vascular endothelial cells from apoptosis due to oxidative stress, and is associated with resistance to atherosclerosis. The gene is hypermethylated in many types of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2011] |
| Chromosome | 16 |
| Location | 16q23.3 |
| Start | 82626794 |
| End | 83796610 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 1169817 |
| OMIM ID | 601364 |
| HGNC ID | HGNC:1753 |
| Unigene ID | Hs.654386 |
| Ensembl ID | ENSG00000140945 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_001220488.1 |
|---|---|
| Exon | join(1..344,12567..12672,231569..231680,405217..405425, 498592..498708,590552..590704,718069..718213, 859684..859862,975661..975801,1043997..1044179, 1051415..1051668,1121315..1121457,1153175..1153408, 1156461..1156679,1168230..1169817) | mRNA Sequence | Download Select all |
| Length | 4134 |
CDS Information
| Location | join(265..344,12567..12672,231569..231680,405217..405425, 498592..498708,590552..590704,718069..718213, 859684..859862,975661..975801,1043997..1044179, 1051415..1051668,1121315..1121457,1153175..1153408, 1156461..1156679,1168230..1168237) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS58485.1 |
Protein Information
| Protein ID | NP_001207417.1 |
|---|---|
| Protein Name | Cadherin 13, H-cadherin (heart) |
| Molecular Wt. (Da) | 83267 |
| Protein Sequence | Download Select all |
| Length | 760 |
| Uniprot ID | P27695 |
| Ensembl Protein ID | ENSP00000216714 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
No STRING Network could be found.
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd11304 | 488-581 | Cadherin_repeat |
| cl15786 | 488-581 | CA_like superfamily |
| cd11304 | 249-359 | Cadherin_repeat |
| cl15786 | 249-359 | CA_like superfamily |
| cd11304 | 367-473 | Cadherin_repeat |
| cl15786 | 367-473 | CA_like superfamily |
| cd11304 | 147-241 | Cadherin_repeat |
| cl15786 | 147-241 | CA_like superfamily |
| cd11304 | 587-680 | Cadherin_repeat |
| cl15786 | 587-680 | CA_like superfamily |
| pfam08758 | 26-112 | Cadherin_pro |
| cl07391 | 26-112 | Cadherin_pro superfamily |
| smart01055 | 27-111 | Cadherin_pro |
| smart00112 | 500-583 | CA |
| smart00112 | 161-243 | CA |
| pfam00028 | 250-351 | Cadherin |
| pfam00028 | 488-576 | Cadherin |
| pfam00028 | 368-469 | Cadherin |
| smart00112 | 268-361 | CA |
| pfam00028 | 144-236 | Cadherin |
| smart00112 | 384-475 | CA |
| pfam00028 | 589-680 | Cadherin |
| cd00031 | 144-241 | CA_like |
| smart00112 | 606-680 | CA |
Ontology Information
| HPRD ID | 136 |
|---|---|
| Molecular Class | Adhesion molecule |
| Molecular Function | DNA repair protein (GO:0003685); Transcription regulator activity (GO:0030528) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.