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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
CDH13 1012 Cadherin 13, H-cadherin (heart)  16CDHH; P105 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
12067979   2002Cell line : -

Source : Dallas, Texas and Baltimore, Maryland.

Sample Type : CRA,CRC tumor and Normal tissue

No. of Sample : 35 CRC 33 normal tissue and 19 CRA

Stage : -

Luciferase assay, Methylation specific -PCR, bisulfite DNA sequencingMethylation-Promoter activity of 5' region of CDH13 show aberrant methylation in colorectal cancers, cell lines, and adenomas.

14997203   2004Cell line : -

Source : Nagoya University School of Medicine from Japanese colorectal cancer patients.

Sample Type : CRC tumor and Normal tissue

No. of Sample : 84

Stage : TNM stage I-III

Bisulphite modification and methylation-specific PCR, RT-PCRMethylation-Specifically methylation of promoter region of CDH13 express H-cadherin and t-cadherin.

Poorly differentiated colorectal cancers specifically exhibited CDH13 methylation, and since CDH13 might be responsible for selective cell recognition and adhesion,inactivation of CDH13 could lead to the formation of scattered carcinoma cells in these cancers.

15793636   2005Cell line : -

Source : -

Sample Type : CRC tumor and Normal tissue

No. of Sample : 61

Stage : TNM stage I-IV

Msethylation specific- PCRMethylation-Colorectal cancers without lymph node metastasis frequently exhibited the aberrant methylation of HLTF , SOCS-1 , and CDH13 genes

17201142   2006Cell line : -

Source : -

Sample Type : CRC tumor and Normal tissue

No. of Sample : 58

Stage : TNM stage I-IV

Msethylation specific- PCRMethylation-Poorly-differentiated colorectal cancers preferentially exhibited gene methylation

21796503   2012Cell line : -

Source : -

Sample Type : CRC tumor and Normal tissue

No. of Sample : 85

Stage : TNM stage I-IV

Msethylation specific- PCRMethylation-Methylation frequencies in cancerous tissues were 31.8% for CDH13 were significantly higher than in corresponding normal tissue.

CDH13 methylation was associated with poor differentiation (P=0.019) and tended to be predominant in advanced stages (P=0.084).

22132162   2011Cell line : -

Source : M.D. Anderson Cancer Center (n =64) or at the Showa University Hospital (n =15).

Sample Type : CRC tumor and Normal tissue

No. of Sample : 79 CRCs, 36 CRCs without liver metastasis (stage I-III) and 43 CRCs with liver metastasis (stage IV/liver recurrence)

Stage : TNM stage I-IV

Bisulfite-pyrosequencing for DNA methylation analysis, Methylation, mutation and definition of CIMP,Methylation-

DNA methylation changes occur for the most part before progression to liver metastasis.

CDH13 have been reported to be altered in primary or metastatic CRCs.

22034905   2011Cell line : 22 gastric and colorectal cancer cell lines

Source : -

Sample Type : -

No. of Sample : -

Stage : -

Exon array, Array-based comparative genomic hybridization, Mutation-Focusing on protein kinase genes and genes belonging to the cadherin-catenin family.

The exon array analysis clearly identified a deletional transcript of CDH13. This abnormal transcripts were shown to have arisen from small genomic deletions.


Gene Details



Chromosome: 16; NC_000016.9 (82660399..83830215)

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Gene Type protein coding
Gene Family Cadherins / Major cadherins
Description This gene encodes a member of the cadherin superfamily. The encoded protein is localized to the surface of the cell membrane and is anchored by a GPI moiety, rather than by a transmembrane domain. The protein lacks the cytoplasmic domain characteristic of other cadherins, and so is not thought to be a cell-cell adhesion glycoprotein. This protein acts as a negative regulator of axon growth during neural differentiation. It also protects vascular endothelial cells from apoptosis due to oxidative stress, and is associated with resistance to atherosclerosis. The gene is hypermethylated in many types of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2011]  
Chromosome 16
Location 16q23.3
Start 82626794  
End 83796610  
Strand +  
Gene Sequence

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Length 1169817  
OMIM ID 601364   
HGNC ID HGNC:1753   
Unigene ID Hs.654386    
Ensembl ID ENSG00000140945   
PharmGKB ID -   

mRNA Information


mRNA ID NM_001220488.1
Exon join(1..344,12567..12672,231569..231680,405217..405425, 498592..498708,590552..590704,718069..718213, 859684..859862,975661..975801,1043997..1044179, 1051415..1051668,1121315..1121457,1153175..1153408, 1156461..1156679,1168230..1169817)  
mRNA Sequence

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Length 4134  



CDS Information


   
Locationjoin(265..344,12567..12672,231569..231680,405217..405425, 498592..498708,590552..590704,718069..718213, 859684..859862,975661..975801,1043997..1044179, 1051415..1051668,1121315..1121457,1153175..1153408, 1156461..1156679,1168230..1168237)
CDS Sequence

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CCDS ID CCDS58485.1



Protein Information


      
Protein IDNP_001207417.1
Protein NameCadherin 13, H-cadherin (heart)
Molecular Wt. (Da)83267
Protein Sequence

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Length 760  
Uniprot IDP27695
Ensembl Protein ID ENSP00000216714  



Post-translational Modification Information (Source : HPRD)


No matching records could be found.

Enzyme Information


No matching records could be found.

PPi Information


No STRING Network could be found.

No matching records from HPRD source could be found.

Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd11304488-581  Cadherin_repeat
cl15786488-581  CA_like superfamily
cd11304249-359  Cadherin_repeat
cl15786249-359  CA_like superfamily
cd11304367-473  Cadherin_repeat
cl15786367-473  CA_like superfamily
cd11304147-241  Cadherin_repeat
cl15786147-241  CA_like superfamily
cd11304587-680  Cadherin_repeat
cl15786587-680  CA_like superfamily
pfam0875826-112  Cadherin_pro
cl0739126-112  Cadherin_pro superfamily
smart0105527-111  Cadherin_pro
smart00112500-583  CA
smart00112161-243  CA
pfam00028250-351  Cadherin
pfam00028488-576  Cadherin
pfam00028368-469  Cadherin
smart00112268-361  CA
pfam00028144-236  Cadherin
smart00112384-475  CA
pfam00028589-680  Cadherin
cd00031144-241  CA_like
smart00112606-680  CA


Ontology Information


   
HPRD ID136
Molecular ClassAdhesion molecule
Molecular FunctionDNA repair protein (GO:0003685); Transcription regulator activity (GO:0030528)
Biological ProcessRegulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO