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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
DLC1 10395 DLC1 Rho GTPase activating protein  8HP, ARHGAP7, STARD12, DLC-1, p122-RhoGAP 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
23359753   2011Cell line : -

Source : Departments of General Surgery of Jiangsu Cancer Hospital and AffiliatedZhongda Hospital, Southeast University

Sample Type : CRC tumor and normal tissue

No. of Sample : 85 CRC patients and 45 patients benign

Stage : -

Methylation-specific PCR,Bisulphite SequencingMethylation-The serum DLC1 methylation may be a promising biomarker for the early detection of CRC, which will further increase the diagnostic efficiency in combination with CEA and CA19-9.

Hypermethylation of DLC1 was detected in 42.4% (36/85) of CRC serums, while seldom in the benign controls(8.9%, 4/45) (P<0.001)


Gene Details



Chromosome 8 - NC_000008.11 (13083361..13515658, complement)

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Gene Type protein coding
Gene Family Rho GTPase activating proteins, "StAR-related lipid transfer (START) domain containing"
Description This gene encodes a GTPase-activating protein (GAP) that is a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins. GAP family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. This gene functions as a tumor suppressor gene in a number of common cancers, including prostate, lung, colorectal, and breast cancers. Multiple transcript variants due to alternative promoters and alternative splicing have been found for this gene.[  
Chromosome 8
Location 8p22
Start 13083361  
End 13515658  
Strand -  
Gene Sequence

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Length 432298  
OMIM ID 604258   
HGNC ID HGNC:2897   
Unigene ID Hs.134296   
Ensembl ID ENSG00000164741   
PharmGKB ID -   

mRNA Information


mRNA ID XM_005273374.1
Exon join(1..200,15463..16610,114040..114189,121966..122106, 210357..210390,400002..400073,404836..404917, 412806..412869,414889..416312,417084..417260, 420414..420573,420702..420900,422834..423047, 424227..424341,425189..425407,426955..427172, 429196..429369,429728..432298)  
mRNA Sequence

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Length 5786  



CDS Information


   
Location join(15588..16610,114040..114189,121966..122106, 210357..210390,400002..400073,404836..404917, 412806..412869,414889..416312,417084..417260, 420414..420573,420702..420900,422834..423047, 424227..424341,425189..425407,426955..427172, 429196..429369,429728..429848)
CDS Sequence

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CCDS ID CCDS5989.1



Protein Information


      
Protein IDNP_001157743.1
Protein NameDLC1 Rho GTPase activating protein
Molecular Wt. (Da)114021
Protein Sequence

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Length 1017  
Uniprot IDP17301
Ensembl Protein ID ENSP00000296585  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation327
SPhosphorylation329
SPhosphorylation567
SPhosphorylation764
SPhosphorylation766
SPhosphorylation1004
SPhosphorylation549
SPhosphorylation986

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

No matching records from HPRD source could be found.

Pathway Information


No matching records could be found.

Structure Information


PDB ID2DKY
Resolution
MethodSOLUTION NMR
Chains A  
Molecule Rho-GTPase-activating protein 7  
Model View



Domain Information




ID Location Description
cd089081315-1518  START_STARD12-like
cl146431315-1518  SRPBCC superfamily
cd043751072-1290  RhoGAP_DLC1
cl025701072-1290  RhoGAP superfamily
cd09591454-513  SAM_DLC1
cl15755454-513  SAM_superfamily superfamily
cd088691323-1518  START_RhoGAP
cd089091316-1515  START_STARD13-like
cd089071320-1515  START_STARD8-like
pfam018521323-1522  START
smart003241089-1252  RhoGAP
smart002341326-1510  START
pfam006201092-1235  RhoGAP
cd001591092-1245  RhoGAP
cd09538454-513  SAM_DLC1,2-like
cd09592450-513  SAM_DLC2
cd043761091-1290  RhoGAP_ARHGAP6
cd043911075-1287  RhoGAP_ARHGAP18
cd044041076-1233  RhoGAP-p50rhoGAP
cd001771333-1500  START
cd043861073-1233  RhoGAP_nadrin
cd043941075-1254  RhoGAP-ARHGAP11A
cd043931075-1250  RhoGAP_FAM13A1a
cd043771076-1252  RhoGAP_myosin_IX
cd043851079-1235  RhoGAP_ARAP
cd043981076-1238  RhoGAP_fRGD1
cd044071076-1234  RhoGAP_myosin_IXB
cd044021076-1246  RhoGAP_ARHGAP20
cd043841074-1234  RhoGAP_CdGAP
cd043741095-1233  RhoGAP_Graf
cd043811076-1233  RhoGap_RalBP1
cd043781076-1233  RhoGAP_GMIP_PARG1
cd043731076-1234  RhoGAP_p190
cd044031076-1248  RhoGAP_ARHGAP27_15_12_9
cd043831074-1235  RhoGAP_srGAP
cd043921076-1293  RhoGAP_ARHGAP19
cd043721076-1233  RhoGAP_chimaerin
cd043791076-1247  RhoGAP_SYD1
cd044061076-1234  RhoGAP_myosin_IXA
cd044081076-1233  RhoGAP_GMIP
cd043971076-1246  RhoGAP_fLRG1
cd043961075-1234  RhoGAP_fSAC7_BAG7
cd044091076-1233  RhoGAP_PARG1
cd043901075-1255  RhoGAP_ARHGAP22_24_25
cd043951075-1233  RhoGAP_ARHGAP21
cd043871076-1233  RhoGAP_Bcr
cd088711330-1495  START_STARD10-like
cd044001075-1233  RhoGAP_fBEM3
cd043821105-1251  RhoGAP_MgcRacGAP
cd043891111-1249  RhoGAP_KIAA1688
cd088761342-1495  START_1
pfam07647453-513  SAM_2
cd088671342-1494  START_STARD4_5_6-like
cd044051075-1222  RhoGAP_BRCC3-like
cd043801101-1255  RhoGAP_OCRL1
cd088681341-1493  START_STARD1_3_like
cd043881107-1234  RhoGAP_p85
smart00454454-513  SAM


Ontology Information


   
HPRD ID1894
Molecular ClassGTPase activating protein
Molecular FunctionReceptor activity (GO:0004872)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO