Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| DLC1 | 10395 | DLC1 Rho GTPase activating protein  | 8 | HP, ARHGAP7, STARD12, DLC-1, p122-RhoGAP  |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23359753    | 2011 | Cell line : - Source : Departments of General Surgery of Jiangsu Cancer Hospital and AffiliatedZhongda Hospital, Southeast University Sample Type : CRC tumor and normal tissue No. of Sample : 85 CRC patients and 45 patients benign Stage : - | Methylation-specific PCR,Bisulphite Sequencing | Methylation | - | The serum DLC1 methylation may be a promising biomarker for the early detection of CRC, which will further increase the diagnostic efficiency in combination with CEA and CA19-9. Hypermethylation of DLC1 was detected in 42.4% (36/85) of CRC serums, while seldom in the benign controls(8.9%, 4/45) (P<0.001) |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | Rho GTPase activating proteins, "StAR-related lipid transfer (START) domain containing" |
| Description | This gene encodes a GTPase-activating protein (GAP) that is a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins. GAP family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. This gene functions as a tumor suppressor gene in a number of common cancers, including prostate, lung, colorectal, and breast cancers. Multiple transcript variants due to alternative promoters and alternative splicing have been found for this gene.[   | Chromosome | 8 |
| Location | 8p22 |
| Start | 13083361   |
| End | 13515658   |
| Strand | -   |
| Gene Sequence |    Download   Select all |
| Length | 432298   |
| OMIM ID | 604258    |
| HGNC ID | HGNC:2897    |
| Unigene ID | Hs.134296    |
| Ensembl ID | ENSG00000164741    |
| PharmGKB ID | -    |
mRNA Information
| mRNA ID | XM_005273374.1 |
|---|---|
| Exon | join(1..200,15463..16610,114040..114189,121966..122106, 210357..210390,400002..400073,404836..404917, 412806..412869,414889..416312,417084..417260, 420414..420573,420702..420900,422834..423047, 424227..424341,425189..425407,426955..427172, 429196..429369,429728..432298)   | mRNA Sequence |    Download   Select all |
| Length | 5786   |
CDS Information
| Location | join(15588..16610,114040..114189,121966..122106, 210357..210390,400002..400073,404836..404917, 412806..412869,414889..416312,417084..417260, 420414..420573,420702..420900,422834..423047, 424227..424341,425189..425407,426955..427172, 429196..429369,429728..429848) |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | CCDS5989.1 |    
Protein Information
| Protein ID | NP_001157743.1 |
|---|---|
| Protein Name | DLC1 Rho GTPase activating protein |
| Molecular Wt. (Da) | 114021 |
| Protein Sequence |    Download   Select all |
| Length | 1017   |
| Uniprot ID | P17301 |    
| Ensembl Protein ID | ENSP00000296585   |    
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 327 |
| S | Phosphorylation | 329 |
| S | Phosphorylation | 567 |
| S | Phosphorylation | 764 |
| S | Phosphorylation | 766 |
| S | Phosphorylation | 1004 |
| S | Phosphorylation | 549 |
| S | Phosphorylation | 986 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
| PDB ID | 2DKY |
|---|---|
| Resolution | |
| Method | SOLUTION NMR |
| Chains | A   |
| Molecule | Rho-GTPase-activating protein 7   |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd08908 | 1315-1518  | START_STARD12-like |
| cl14643 | 1315-1518  | SRPBCC superfamily |
| cd04375 | 1072-1290  | RhoGAP_DLC1 |
| cl02570 | 1072-1290  | RhoGAP superfamily |
| cd09591 | 454-513  | SAM_DLC1 |
| cl15755 | 454-513  | SAM_superfamily superfamily |
| cd08869 | 1323-1518  | START_RhoGAP |
| cd08909 | 1316-1515  | START_STARD13-like |
| cd08907 | 1320-1515  | START_STARD8-like |
| pfam01852 | 1323-1522  | START |
| smart00324 | 1089-1252  | RhoGAP |
| smart00234 | 1326-1510  | START |
| pfam00620 | 1092-1235  | RhoGAP |
| cd00159 | 1092-1245  | RhoGAP |
| cd09538 | 454-513  | SAM_DLC1,2-like |
| cd09592 | 450-513  | SAM_DLC2 |
| cd04376 | 1091-1290  | RhoGAP_ARHGAP6 |
| cd04391 | 1075-1287  | RhoGAP_ARHGAP18 |
| cd04404 | 1076-1233  | RhoGAP-p50rhoGAP |
| cd00177 | 1333-1500  | START |
| cd04386 | 1073-1233  | RhoGAP_nadrin |
| cd04394 | 1075-1254  | RhoGAP-ARHGAP11A |
| cd04393 | 1075-1250  | RhoGAP_FAM13A1a |
| cd04377 | 1076-1252  | RhoGAP_myosin_IX |
| cd04385 | 1079-1235  | RhoGAP_ARAP |
| cd04398 | 1076-1238  | RhoGAP_fRGD1 |
| cd04407 | 1076-1234  | RhoGAP_myosin_IXB |
| cd04402 | 1076-1246  | RhoGAP_ARHGAP20 |
| cd04384 | 1074-1234  | RhoGAP_CdGAP |
| cd04374 | 1095-1233  | RhoGAP_Graf |
| cd04381 | 1076-1233  | RhoGap_RalBP1 |
| cd04378 | 1076-1233  | RhoGAP_GMIP_PARG1 |
| cd04373 | 1076-1234  | RhoGAP_p190 |
| cd04403 | 1076-1248  | RhoGAP_ARHGAP27_15_12_9 |
| cd04383 | 1074-1235  | RhoGAP_srGAP |
| cd04392 | 1076-1293  | RhoGAP_ARHGAP19 |
| cd04372 | 1076-1233  | RhoGAP_chimaerin |
| cd04379 | 1076-1247  | RhoGAP_SYD1 |
| cd04406 | 1076-1234  | RhoGAP_myosin_IXA |
| cd04408 | 1076-1233  | RhoGAP_GMIP |
| cd04397 | 1076-1246  | RhoGAP_fLRG1 |
| cd04396 | 1075-1234  | RhoGAP_fSAC7_BAG7 |
| cd04409 | 1076-1233  | RhoGAP_PARG1 |
| cd04390 | 1075-1255  | RhoGAP_ARHGAP22_24_25 |
| cd04395 | 1075-1233  | RhoGAP_ARHGAP21 |
| cd04387 | 1076-1233  | RhoGAP_Bcr |
| cd08871 | 1330-1495  | START_STARD10-like |
| cd04400 | 1075-1233  | RhoGAP_fBEM3 |
| cd04382 | 1105-1251  | RhoGAP_MgcRacGAP |
| cd04389 | 1111-1249  | RhoGAP_KIAA1688 |
| cd08876 | 1342-1495  | START_1 |
| pfam07647 | 453-513  | SAM_2 |
| cd08867 | 1342-1494  | START_STARD4_5_6-like |
| cd04405 | 1075-1222  | RhoGAP_BRCC3-like |
| cd04380 | 1101-1255  | RhoGAP_OCRL1 |
| cd08868 | 1341-1493  | START_STARD1_3_like |
| cd04388 | 1107-1234  | RhoGAP_p85 |
| smart00454 | 454-513  | SAM |
Ontology Information
| HPRD ID | 1894 |    
|---|---|
| Molecular Class | GTPase activating protein |
| Molecular Function | Receptor activity (GO:0004872) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165)   |
Drug Information
No matching records could be found.
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
