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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
IPO7 10527 Importin 7  11Imp7; RANBP7 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
10799331   2000Cell line : -

Source : Royal London Hospital.

Sample Type : CRC tumor and normal tissue

No. of Sample : 75

Stage : -

real time RT-PCR Up-regulation-Elevated levels of RanBP7 mRNA in colorectal carcinoma are associated with increased proliferation and are similar to the transcription pattern of the proto-oncogene c-myc.

RanBP7 mRNA levels were elevated in 47/75 colorectal tumours.

22968445   2012Cell line : -

Source : Department of Pathology of Wrocaw Medical University.

Sample Type : CRC tumor and normal tissue

No. of Sample : 8

Stage : -

Laser capture microdissection,FFPE-FASP,SAX fractionation,LC-MSMS,Label-free quantitation.Up-regulation6-


Gene Details



Chromosome: 11; NC_000011.9 (9406169..9469674)

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Gene Type protein coding
Gene Family Importins
Description The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. Similar to importin-beta, this protein prevents the activation of Ran's GTPase by RanGAP1 and inhibits nucleotide exchange on RanGTP, and also binds directly to nuclear pore complexes where it competes for binding sites with importin-beta and transportin. This protein has a Ran-dependent transport cycle and it can cross the nuclear envelope rapidly and in both directions. At least four importin beta-like transport receptors, namely importin beta itself, transportin, RanBP5 and RanBP7, directly bind and import ribosomal proteins. [provided by RefSeq, Jul 2008]  
Chromosome 11
Location 11p15.4
Start 9384622  
End 9448127  
Strand +  
Gene Sequence

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Length 63506  
OMIM ID 605586   
HGNC ID HGNC:9852   
Unigene ID Hs.744911   
Ensembl ID ENSG00000205339   
PharmGKB ID -   

mRNA Information


mRNA ID NM_006391.2
Exon join(1..226,18669..18750,23865..24018,25307..25465, 29634..29790,32438..32527,35790..35884,35993..36077, 38385..38519,39156..39255,40293..40369,40525..40641, 43919..44008,44410..44575,45053..45213,46254..46382, 48949..49015,49100..49225,50313..50410,51650..51745, 53133..53353,53459..53664,55834..56040,57460..57576, 60476..63506)  
mRNA Sequence

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Length 6209  



CDS Information


   
Locationjoin(143..226,18669..18750,23865..24018,25307..25465, 29634..29790,32438..32527,35790..35884,35993..36077, 38385..38519,39156..39255,40293..40369,40525..40641, 43919..44008,44410..44575,45053..45213,46254..46382, 48949..49015,49100..49225,50313..50410,51650..51745, 53133..53353,53459..53664,55834..56040,57460..57576, 60476..60573)
CDS Sequence

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CCDS ID CCDS31425.1



Protein Information


      
Protein IDNP_006382.1
Protein NameImportin 7
Molecular Wt. (Da)119386
Protein Sequence

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Length 1038  
Uniprot IDP18074
Ensembl Protein ID ENSP00000375809  



Post-translational Modification Information (Source : HPRD)


Residue Type site
YPhosphorylation311;-
TPhosphorylation898;-
SPhosphorylation903;-
YPhosphorylation876;-
SPhosphorylation886;-
YPhosphorylation915;-
SPhosphorylation438
TPhosphorylation43

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                          
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
3005H1F0819NP_005309.1in vitro10228156   
3837KPNB14114NP_002256.2in vitro102   281   569   214   382   
5901RAN3109NP_006316.1in vitro9214382   
6125RPL54699NP_000960.2in vitro9687515   
6201RPS74712NP_001002.1in vitro9687515   
6728SRP191644NP_003126.1in vitro11682607   


Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
pfam0381022-101  IBN_N
cl0427122-101  IBN_N superfamily
smart0091322-101  IBN_N
pfam08506203-440  Cse1
cl20359203-440  Cse1 superfamily
COG565615-997  SXM1
COG565713-683  CSE1


Ontology Information


   
HPRD ID596
Molecular ClassTransport/cargo protein
Molecular FunctionDNA repair protein (GO:0003685)
Biological ProcessDNA repair (GO:0006281)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO