Search results:
General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 10799331    | 2000 | Cell line : - Source : Royal London Hospital. Sample Type : CRC tumor and normal tissue No. of Sample : 75 Stage : - | real time RT-PCR | Up-regulation | - | Elevated levels of RanBP7 mRNA in colorectal carcinoma are associated with increased proliferation and are similar to the transcription pattern of the proto-oncogene c-myc. RanBP7 mRNA levels were elevated in 47/75 colorectal tumours. |
| 22968445    | 2012 | Cell line : - Source : Department of Pathology of Wrocaw Medical University. Sample Type : CRC tumor and normal tissue No. of Sample : 8 Stage : - | Laser capture microdissection,FFPE-FASP,SAX fractionation,LC-MSMS,Label-free quantitation. | Up-regulation | 6 | - |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | Importins |
| Description | The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. Similar to importin-beta, this protein prevents the activation of Ran's GTPase by RanGAP1 and inhibits nucleotide exchange on RanGTP, and also binds directly to nuclear pore complexes where it competes for binding sites with importin-beta and transportin. This protein has a Ran-dependent transport cycle and it can cross the nuclear envelope rapidly and in both directions. At least four importin beta-like transport receptors, namely importin beta itself, transportin, RanBP5 and RanBP7, directly bind and import ribosomal proteins. [provided by RefSeq, Jul 2008]   | Chromosome | 11 |
| Location | 11p15.4 |
| Start | 9384622   |
| End | 9448127   |
| Strand | +   |
| Gene Sequence |    Download   Select all |
| Length | 63506   |
| OMIM ID | 605586    |
| HGNC ID | HGNC:9852    |
| Unigene ID | Hs.744911    |
| Ensembl ID | ENSG00000205339    |
| PharmGKB ID | -    |
mRNA Information
| mRNA ID | NM_006391.2 |
|---|---|
| Exon | join(1..226,18669..18750,23865..24018,25307..25465, 29634..29790,32438..32527,35790..35884,35993..36077, 38385..38519,39156..39255,40293..40369,40525..40641, 43919..44008,44410..44575,45053..45213,46254..46382, 48949..49015,49100..49225,50313..50410,51650..51745, 53133..53353,53459..53664,55834..56040,57460..57576, 60476..63506)   | mRNA Sequence |    Download   Select all |
| Length | 6209   |
CDS Information
| Location | join(143..226,18669..18750,23865..24018,25307..25465, 29634..29790,32438..32527,35790..35884,35993..36077, 38385..38519,39156..39255,40293..40369,40525..40641, 43919..44008,44410..44575,45053..45213,46254..46382, 48949..49015,49100..49225,50313..50410,51650..51745, 53133..53353,53459..53664,55834..56040,57460..57576, 60476..60573) |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | CCDS31425.1 |    
Protein Information
| Protein ID | NP_006382.1 |
|---|---|
| Protein Name | Importin 7 |
| Molecular Wt. (Da) | 119386 |
| Protein Sequence |    Download   Select all |
| Length | 1038   |
| Uniprot ID | P18074 |    
| Ensembl Protein ID | ENSP00000375809   |    
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 311;- |
| T | Phosphorylation | 898;- |
| S | Phosphorylation | 903;- |
| Y | Phosphorylation | 876;- |
| S | Phosphorylation | 886;- |
| Y | Phosphorylation | 915;- |
| S | Phosphorylation | 438 |
| T | Phosphorylation | 43 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 3005 |    H1F0 |    819 |    NP_005309.1 |    in vitro |    10228156    |
| 3837 |    KPNB1 |    4114 |    NP_002256.2 |    in vitro |    102   281   569   214   382    |
| 5901 |    RAN |    3109 |    NP_006316.1 |    in vitro |    9214382    |
| 6125 |    RPL5 |    4699 |    NP_000960.2 |    in vitro |    9687515    |
| 6201 |    RPS7 |    4712 |    NP_001002.1 |    in vitro |    9687515    |
| 6728 |    SRP19 |    1644 |    NP_003126.1 |    in vitro |    11682607    |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam03810 | 22-101  | IBN_N |
| cl04271 | 22-101  | IBN_N superfamily |
| smart00913 | 22-101  | IBN_N |
| pfam08506 | 203-440  | Cse1 |
| cl20359 | 203-440  | Cse1 superfamily |
| COG5656 | 15-997  | SXM1 |
| COG5657 | 13-683  | CSE1 |
Ontology Information
| HPRD ID | 596 |    
|---|---|
| Molecular Class | Transport/cargo protein |
| Molecular Function | DNA repair protein (GO:0003685) |
| Biological Process | DNA repair (GO:0006281)   |
Drug Information
No matching records could be found.
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
