Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| PTPRT | 11122 | protein tyrosine phosphatase, receptor type, T  | 20 | RPTPrho, KIAA0283  |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23096495    | 2013 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 131 Stage : - | methyl specific PCR and Illumina 27K microarray | Hypermethylation | - | PTPR family has an important role in the etiology of CRC. The analysis of promoter methylation using an Illumina 27K microarray revealed four protein tyrosine phosphatases PTPRM, PTPRT, PTPRR and PTPRZ1 as being hypermethylated with p-value p 0.2 and P 0.05. |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | Protein tyrosine phosphatases / Class I Cys-based PTPs : Transmembrane receptor-like, "Immunoglobulin superfamily / Immunoglobulin-like domain containing", "Fibronectin type III domain containing" |
| Description | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. The protein domain structure and the expression pattern of the mouse counterpart of this PTP suggest its roles in both signal transduction and cellular adhesion in the central nervous system. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.   |
| Chromosome | 20 |
| Location | 20q12-q13 |
| Start | 42072752   |
| End | 43189917   |
| Strand | -   |
| Gene Sequence |    Download   Select all |
| Length | 1117166   |
| OMIM ID | 608712    |
| HGNC ID | HGNC:9682    |
| Unigene ID | Hs.526879    |
| Ensembl ID | ENSG00000196090    |
| PharmGKB ID | -    |
mRNA Information
| mRNA ID | NM_007050.5 |
|---|---|
| Exon | join(1..272,303986..304111,398452..398723,409619..409700, 418368..418483,433282..433456,511759..512052, 717356..717652,741589..741698,837633..837834, 839188..839290,873922..874195,907393..907429, 941096..941231,953660..953689,990530..990678, 1028376..1028566,1047916..1048003,1061088..1061164, 1069947..1069983,1071418..1071515,1074603..1074719, 1079431..1079585,1082997..1083132,1085200..1085349, 1087621..1087794,1091366..1091497,1104065..1104190, 1105073..1105236,1107901..1108036,1108986..1117166)   | mRNA Sequence |    Download   Select all |
| Length | 12644   |
CDS Information
| Location | join(185..272,303986..304111,398452..398723, 409619..409700,418368..418483,433282..433456, 511759..512052,717356..717652,741589..741698, 837633..837834,839188..839290,873922..874195, 907393..907429,919465..919521,941096..941231, 953660..953689,990530..990678,1028376..1028566, 1047916..1048003,1048314..1048436,1061088..1061164, 1069947..1069983,107141 |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | - |    
Protein Information
| Protein ID | NP_573400.3 |
|---|---|
| Protein Name | protein tyrosine phosphatase, receptor type, T |
| Molecular Wt. (Da) | 161436 |
| Protein Sequence |    Download   Select all |
| Length | 1460   |
| Uniprot ID | P23458 |    
| Ensembl Protein ID | ENSP00000343204   |    
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
| EC | 3.1.3.48 |    
|---|---|
| Name | protein-tyrosine-phosphatase phosphotyrosine phosphatase phosphoprotein phosphatase (phosphotyrosine) phosphotyrosine histone phosphatase protein phosphotyrosine phosphatase tyrosylprotein phosphatase phosphotyrosine protein phosphatase phosphotyrosylprotein phosphatase tyrosine O-phosphate phosphatase PPT-phosphatase PTPase [phosphotyrosine]protein phosphatase PTP-phosphatase |
| Class | Hydrolases; Acting on ester bonds; Phosphoric-monoester hydrolases |
| Sysname | protein-tyrosine-phosphate phosphohydrolase   |
| Substrate | protein tyrosine phosphate [CPD:C01167]; H2O   |
| Product | protein tyrosine [CPD:C00585]; phosphate   |
| Reaction (IUBMB) | ![]() |
PPi Information
(Click to view network : Source STRING)      View   
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00047 | 915-1142  | PTPc |
| cl21483 | 915-1142  | PTPc superfamily |
| cd00047 | 1204-1436  | PTPc |
| cl21483 | 1204-1436  | PTPc superfamily |
| cd06263 | 32-189  | MAM |
| cl18943 | 32-189  | MAM superfamily |
| cd00063 | 502-584  | FN3 |
| cl21522 | 502-584  | FN3 superfamily |
| cd00063 | 390-480  | FN3 |
| cl21522 | 390-480  | FN3 superfamily |
| cd00063 | 289-360  | FN3 |
| cl21522 | 289-360  | FN3 superfamily |
| smart00404 | 1041-1142  | PTPc_motif |
| smart00012 | 1041-1142  | PTPc_DSPc |
| smart00404 | 1331-1436  | PTPc_motif |
| smart00012 | 1331-1436  | PTPc_DSPc |
| pfam00041 | 502-577  | fn3 |
| smart00060 | 502-575  | FN3 |
| smart00060 | 390-470  | FN3 |
| pfam00041 | 294-360  | fn3 |
| smart00060 | 289-360  | FN3 |
| pfam13895 | 195-285  | Ig_2 |
| cl11960 | 195-285  | Ig superfamily |
| pfam00041 | 390-469  | fn3 |
| smart00194 | 888-1142  | PTPc |
| smart00194 | 1174-1436  | PTPc |
| smart00137 | 29-189  | MAM |
| pfam00102 | 912-1142  | Y_phosphatase |
| pfam00102 | 1202-1436  | Y_phosphatase |
| COG5599 | 903-1142  | COG5599 |
| PHA02738 | 909-1140  | PHA02738 |
| PHA02742 | 889-1142  | PHA02742 |
| PHA02747 | 891-1137  | PHA02747 |
| pfam00629 | 32-191  | MAM |
| PHA02746 | 911-1140  | PHA02746 |
| COG5599 | 1158-1441  | COG5599 |
| PHA02747 | 1200-1439  | PHA02747 |
| PHA02746 | 1203-1433  | PHA02746 |
| PHA02742 | 1157-1437  | PHA02742 |
| PHA02738 | 1201-1440  | PHA02738 |
| PHA02740 | 869-1140  | PHA02740 |
| PHA02740 | 1202-1439  | PHA02740 |
| COG2453 | 1050-1137  | CDC14 |
| COG2453 | 1335-1435  | CDC14 |
Ontology Information
| HPRD ID | 2547 |    
|---|---|
| Molecular Class | Receptor tyrosine phosphatase |
| Molecular Function | Protein-tyrosine kinase activity (GO:0004713) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165)   |
Drug Information
No matching records could be found.
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    

