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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
PTPRT 11122 protein tyrosine phosphatase, receptor type, T  20RPTPrho, KIAA0283 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
23096495   2013Cell line : -

Source : -

Sample Type : CRC tumor and normal tissue

No. of Sample : 131

Stage : -

methyl specific PCR and Illumina 27K microarray Hypermethylation-PTPR family has an important role in the etiology of CRC.

The analysis of promoter methylation using an Illumina 27K microarray revealed four protein tyrosine phosphatases PTPRM, PTPRT, PTPRR and PTPRZ1 as being hypermethylated with p-value p 0.2 and P 0.05.


Gene Details



Chromosome 20 - NC_000020.11 (42072752..43189917, complement)

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Gene Type protein coding
Gene Family Protein tyrosine phosphatases / Class I Cys-based PTPs : Transmembrane receptor-like, "Immunoglobulin superfamily / Immunoglobulin-like domain containing", "Fibronectin type III domain containing"
Description The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. The protein domain structure and the expression pattern of the mouse counterpart of this PTP suggest its roles in both signal transduction and cellular adhesion in the central nervous system. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.  
Chromosome 20
Location 20q12-q13
Start 42072752  
End 43189917  
Strand -  
Gene Sequence

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Length 1117166  
OMIM ID 608712   
HGNC ID HGNC:9682   
Unigene ID Hs.526879   
Ensembl ID ENSG00000196090   
PharmGKB ID -   

mRNA Information


mRNA ID NM_007050.5
Exon join(1..272,303986..304111,398452..398723,409619..409700, 418368..418483,433282..433456,511759..512052, 717356..717652,741589..741698,837633..837834, 839188..839290,873922..874195,907393..907429, 941096..941231,953660..953689,990530..990678, 1028376..1028566,1047916..1048003,1061088..1061164, 1069947..1069983,1071418..1071515,1074603..1074719, 1079431..1079585,1082997..1083132,1085200..1085349, 1087621..1087794,1091366..1091497,1104065..1104190, 1105073..1105236,1107901..1108036,1108986..1117166)  
mRNA Sequence

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Length 12644  



CDS Information


   
Location join(185..272,303986..304111,398452..398723, 409619..409700,418368..418483,433282..433456, 511759..512052,717356..717652,741589..741698, 837633..837834,839188..839290,873922..874195, 907393..907429,919465..919521,941096..941231, 953660..953689,990530..990678,1028376..1028566, 1047916..1048003,1048314..1048436,1061088..1061164, 1069947..1069983,107141
CDS Sequence

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CCDS ID -



Protein Information


      
Protein IDNP_573400.3
Protein Nameprotein tyrosine phosphatase, receptor type, T
Molecular Wt. (Da)161436
Protein Sequence

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Length 1460  
Uniprot IDP23458
Ensembl Protein ID ENSP00000343204  



Post-translational Modification Information (Source : HPRD)


No matching records could be found.

Enzyme Information


   
EC3.1.3.48
Nameprotein-tyrosine-phosphatase
phosphotyrosine phosphatase
phosphoprotein phosphatase (phosphotyrosine)
phosphotyrosine histone phosphatase
protein phosphotyrosine phosphatase
tyrosylprotein phosphatase
phosphotyrosine protein phosphatase
phosphotyrosylprotein phosphatase
tyrosine O-phosphate phosphatase
PPT-phosphatase
PTPase
[phosphotyrosine]protein phosphatase
PTP-phosphatase
ClassHydrolases; Acting on ester bonds; Phosphoric-monoester hydrolases
Sysnameprotein-tyrosine-phosphate phosphohydrolase  
Substrateprotein tyrosine phosphate [CPD:C01167]; H2O  
Productprotein tyrosine [CPD:C00585]; phosphate  
Reaction (IUBMB)



PPi Information


(Click to view network : Source STRING)      View   

No matching records from HPRD source could be found.

Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd00047915-1142  PTPc
cl21483915-1142  PTPc superfamily
cd000471204-1436  PTPc
cl214831204-1436  PTPc superfamily
cd0626332-189  MAM
cl1894332-189  MAM superfamily
cd00063502-584  FN3
cl21522502-584  FN3 superfamily
cd00063390-480  FN3
cl21522390-480  FN3 superfamily
cd00063289-360  FN3
cl21522289-360  FN3 superfamily
smart004041041-1142  PTPc_motif
smart000121041-1142  PTPc_DSPc
smart004041331-1436  PTPc_motif
smart000121331-1436  PTPc_DSPc
pfam00041502-577  fn3
smart00060502-575  FN3
smart00060390-470  FN3
pfam00041294-360  fn3
smart00060289-360  FN3
pfam13895195-285  Ig_2
cl11960195-285  Ig superfamily
pfam00041390-469  fn3
smart00194888-1142  PTPc
smart001941174-1436  PTPc
smart0013729-189  MAM
pfam00102912-1142  Y_phosphatase
pfam001021202-1436  Y_phosphatase
COG5599903-1142  COG5599
PHA02738909-1140  PHA02738
PHA02742889-1142  PHA02742
PHA02747891-1137  PHA02747
pfam0062932-191  MAM
PHA02746911-1140  PHA02746
COG55991158-1441  COG5599
PHA027471200-1439  PHA02747
PHA027461203-1433  PHA02746
PHA027421157-1437  PHA02742
PHA027381201-1440  PHA02738
PHA02740869-1140  PHA02740
PHA027401202-1439  PHA02740
COG24531050-1137  CDC14
COG24531335-1435  CDC14


Ontology Information


   
HPRD ID2547
Molecular ClassReceptor tyrosine phosphatase
Molecular FunctionProtein-tyrosine kinase activity (GO:0004713)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO