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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
CLIC2 1193 Chloride intracellular channel 2  XCLIC2b; MRXS32; XAP121 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
22968445   2012Cell line : -

Source : Department of Pathology of Wrocaw Medical University.

Sample Type : -

No. of Sample : -

Stage : -

Laser capture microdissection,FFPE-FASP,SAX fractionation,LC-MSMS,Label-free quantitation.Down-regulation0.026-


Gene Details



Chromosome: X; NC_000023.10 (154505500..154563986, complement)

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Gene Type protein coding
Gene Family Ion channels / Chloride channels : Intracellular
Description Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 2 is a member of the p64 family; the protein is detected in fetal liver and adult skeletal muscle tissue. This gene maps to the candidate region on chromosome X for incontinentia pigmenti. [provided by RefSeq, Jul 2008]  
Chromosome X
Location Xq28
Start 155276207  
End 155334681  
Strand -  
Gene Sequence

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Length 58475  
OMIM ID 300138   
HGNC ID HGNC:2063   
Unigene ID Hs.655445    
Ensembl ID ENSG00000155962   
PharmGKB ID -   

mRNA Information


mRNA ID NM_001289.5
Exon join(1..311,35537..35646,35772..35897,54614..54720, 55352..55533,56618..58475)  
mRNA Sequence

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Length 2702  



CDS Information


   
Location join(255..311,35537..35646,35772..35897,54614..54720, 55352..55533,56618..56779)
CDS Sequence

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CCDS ID CCDS14767.1



Protein Information


      
Protein IDNP_001280.3
Protein NameChloride intracellular channel 2
Molecular Wt. (Da)28225
Protein Sequence

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Length 247  
Uniprot IDP07288
Ensembl Protein ID ENSP00000314151  



Post-translational Modification Information (Source : HPRD)


No matching records could be found.

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

No matching records from HPRD source could be found.

Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd10298106-244  GST_C_CLIC2
cl02776106-244  GST_C_family superfamily
cd03061Sep-99  GST_N_CLIC
cl00388Sep-99  Thioredoxin_like superfamily
cd10297106-245  GST_C_CLIC5
cd10296106-245  GST_C_CLIC4
cd10301106-245  GST_C_CLIC6
cd10300108-244  GST_C_CLIC1
cd03198106-240  GST_C_CLIC
cd10299106-239  GST_C_CLIC3
cd03201107-235  GST_C_DHAR
pfam1340930-93  GST_N_2
cd0057029-91  GST_N_family
pfam1341730-98  GST_N_3
cd0305929-74  GST_N_SspA
cd0029986-218  GST_C_family
pfam13410169-216  GST_C_2
cd03177110-200  GST_C_Delta_Epsilon
cd0305530-59  GST_N_Omega
cd0306030-91  GST_N_Omega_like
cd10424176-216  GST_C_9
cd03190127-229  GST_C_Omega_like
TIGR0086212-245  O-ClC
PLN0281714-232  PLN02817
PLN0237814-240  PLN02378
PRK0948143-106  sspA


Ontology Information


   
HPRD ID1461
Molecular ClassIntracellular ligand gated channel
Molecular FunctionSerine-type peptidase activity (GO:0008236)
Biological ProcessProteolysis and peptidolysis (GO:0006508); Immune response (GO:0006955)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO