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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
CNN2 1265 Calponin 2  19- 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
21331762   2011Cell line : -

Source : -

Sample Type : -

No. of Sample : 12 CRC patients

Stage : -

Real-time RT-PCR and DNA sequencing analysisUp-regulation-Results revealed that ST3GAL5, IFITM3, PDAP1, ALKBH3, NUDT14, CNN2, MAPK14, ACO1, and SEPHS1 may be involved in rectal carcinogenesis.

22968445   2012Cell line : -

Source : Department of Pathology of Wroc$aw Medical University.

Sample Type : -

No. of Sample : -

Stage : -

Laser capture microdissection,FFPE-FASP,SAX fractionation,LC-MSMS,Label-free quantitation.Up-regulation8.9-


Gene Details



Chromosome: 19; NC_000019.9 (1026298..1039064)

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Gene Type protein coding
Gene Family -
Description The protein encoded by this gene, which can bind actin, calmodulin, troponin C, and tropomyosin, may function in the structural organization of actin filaments. The encoded protein could play a role in smooth muscle contraction and cell adhesion. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]  
Chromosome 19
Location 19p13.3
Start 1026275  
End 1039068  
Strand +  
Gene Sequence

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Length 12794  
OMIM ID 602373   
HGNC ID HGNC:2156   
Unigene ID Hs.651512   
Ensembl ID ENSG00000064666   
PharmGKB ID -   

mRNA Information


mRNA ID NM_001303501.1
Exon join(1..450,4797..4918,6118..6184,6285..6422,9793..9972, 10142..10288,11351..12794)  
mRNA Sequence

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Length 2478  



CDS Information


   
Location join(388..450,4797..4918,6118..6184,6285..6422,9793..9972, 10142..10288,11351..11626)
CDS Sequence

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CCDS ID -



Protein Information


      
Protein IDNP_004359.1
Protein NameCalponin 2
Molecular Wt. (Da)33566
Protein Sequence

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Length 309  
Uniprot IDP29972
Ensembl Protein ID ENSP00000311165  



Post-translational Modification Information (Source : HPRD)


Residue Type site
YPhosphorylation303;-
YPhosphorylation264;-
YPhosphorylation184;-
YPhosphorylation145;-
KAcetylation25
KAcetylation25
KAcetylation8
KAcetylation8
TPhosphorylation172

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

               
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
60ACTB32NP_001092.1in vivo12388067   


Pathway Information


No matching records could be found.

Structure Information


PDB ID1WYN
Resolution-
Methodsolution NMR
Chains A  
Molecule Calponin-2  
Model View



Domain Information




ID Location Description
cd0001431-131  CH
cl0003031-131  CH superfamily
smart0003333-127  CH
pfam0030731-127  CH
pfam00402166-191  Calponin
cl02859166-191  Calponin superfamily
pfam00402206-231  Calponin
cl02859206-231  Calponin superfamily
pfam00402245-269  Calponin
cl02859245-269  Calponin superfamily
COG519919-190  SCP1
COG526133-136  IQG1


Ontology Information


   
HPRD ID140
Molecular ClassCytoskeletal associated protein
Molecular FunctionWater channel activity (GO:0015250)
Biological ProcessTransport (GO:0006810); Ion transport (GO:0006811)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO