CoReCG

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
20812987	2010	Cell line : - Source : Nanfang Hospital tumour tissue bank. Sample Type : CRC tumor and Normal tissue No. of Sample : 150 Stage : -	Two-dimensional gel electrophoresis, and mass spectrometry,Western blot analysis, Immunohistochemist	Down-regulation	-	This gene differentially expressed in between normal colorectal tissue and colorectal cancer tissue experiment done by 2-D Gel eclectrophotesis

Gene Details

Chromosome: 11; NC_000011.9 (111779350..111782473, complement)
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Gene Type	protein coding
Gene Family	Heat shock proteins / HSPB
Description	Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (sHSP also known as the HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases; a missense mutation cosegregated in a family with a desmin-related myopathy. [provided by RefSeq, Jul 2008]
Chromosome	11
Location	11q22.3-q2
Start	111908620
End	111913213
Strand	-
Gene Sequence	>gi\|568815587:c111913213-111908620 Homo sapiens chromosome 11, GRCh38.p2 Primary Assembly AGGAGGAGGAGGCACCAAACGGCCTGGGTGGATAGAAGGGGGACAAGGAGGCACACCCAGGCCGGCAAAG AGCAGGTATCAGCACTGCAAGCACCAAGTGTGTCTTGAGGTCAGCAGGAATGGGAAAGATCTCTGCTTGG AGGGGATGAGGGGTAGTCTGGGGTGGGGGGTGGCTGGTCCCAGGAGATCAGTTAAGCCCAGAGTGGGGTG GAGGCCAGCAACGTTGGGAGGTCAGCCCAGAATTTCAGGGGGTGGGGGTGGGGGGCAAGGGGGTGGTGTC TGTGCCATACCTTCTCCGAAGCGCTGCTCACCCAGGCGGCTCGGGTTGGCAAATTCGTACTCGGCGGTGG CCGGGTGGGCATGTGGCACTGAGCGGCCCGACATGGCTGCAGATGCAGCAGAAGCCCTGGTCCGAGGTGC AGCCCCAACAGGCGCAGCGCGACCCCTCCAGCTGCCCGGAGAGCCAGGGCTCGATAGGAGGTGGGGGCGG GGTCGACACCACCCAAAATAGTGCCGAGCCTCTTGGGGGGGGAGGGGCTGGGAGTGGGGGCCCTGAGTGA GAGCAACGAGGGTGTGACCAGCGCCGCCCGGACCCCTAGTCCCCTCCCCCGCACACTCTTCAGCTGTCGC AGGGGGCCTGAGAGGACAGCTGAGGGTCCTGGCTGGGAACGAGCTGGGGAGGGGGAGCTGGTGGTGCCTG GGGCATGAAGAGGCCTCGCTGAGACCCTCACAAACGGTTTGCACGTTTCCACACCTCATTTTCTCCTCTT CGGTGGCAGGCACTGTGCACCCAATTCCTAAAGCACTCCTGGATTTAATGTTCTGAGAGCCACATAGAAC GAAAGATGCAAGAAATCTGTTTGCTCTTTTTTCAGGGGGTGGGGTCTTTCTGCCCAGATGTGGGATCCTC TCCTAAACCCAGGTCAACCCAGGGCACGAGGCAGATGGCTGGTGCTGACATGTTGACCATCACTGCTCTC TTCCAAGGACTCACAAAGAGTTAATGTCCCTGGGGCTCAGCCTAGGAAGATTCCAGTCCCTGCCCAGGCC CAAGATAGTTGCTGGCCTGATTCCCCTGGCATTCAGGACTGGAAAGGAGGAGGAGGGGCACACTACGCCG GCTCCCATCCTCCCCCCACCCCGCGTGCCTGCTTGGGATTCCTGACTCTGTACCAGCTTCAGAGAACAGG GGTGGGGGTGGGTGCCATTGGGTGTGGACAGAAAGCTAGTGAAACAAGACCATGACAAGTCACTGGCCGG CTCAGACGTGTTTGTGTCTCTCTTTTCTTAGCTCAGTGAGTACTGGGTATGTGTCACATTGCCAAATCCC GGATCACAAGTCTCCATGAACTGCTGGTGAGCTAGGATAATAAAACCCCTGACATCACCATTCCAGAAGC TTCACAAGACTGCATATATAAGGGGCTGGCTGTAGCTGCAGCTGAAGGAGCTGACCAGCCAGCTGACCCC TCACACTCACCTAGCCACCATGGACATCGCCATCCACCACCCCTGGATCCGCCGCCCCTTCTTTCCTTTC CACTCCCCCAGCCGCCTCTTTGACCAGTTCTTCGGAGAGCACCTGTTGGAGTCTGATCTTTTCCCGACGT CTACTTCCCTGAGTCCCTTCTACCTTCGGCCACCCTCCTTCCTGCGGGCACCCAGCTGGTTTGACACTGG ACTCTCAGAGGTGAGTCTCCCCACAGCTAGGACGGGAGAGTCCTTACTGGAACCTCCTGGAAACTTCTCC ATCCATTTTCCTTTCCTACCCTGCCTAAACCATTTTAGGCACATGTGTGTCCAAATGTGAAGAAAAATGA GGAGGTTGCTAGTGCCTTCCTCCCCCATCACCTGTTTCTATTTGATAGTCCTCTGTATCCCATTTATTAC ATTTTTTCATGCACTGTCAAGTTTATCCTCCGTCCCCTAACTTCTCTACAGGATACCCCTTTCTGGTTTG GTTCATGACAATCTGCAGGGAAAGAGCTGCCTTCAAACTCCTTTGCTTATCTCTTCCAACACCTTGGACT CTTGACCGATTTTACCATCTCAGGTTTCAGAGCCAGGAGAGAGCCCTGCCTCATCCTGAGCTGTTCATCC CCATGGGTATTTTCTGCCTTTCTATTCCCTCTTCTATGATTTTCTGGGTTTCTCAGGGCTACGACAGGGC GCTGGCCTGGGTCCAATCAAGCCCTACGAGGAAACAATATAGGGACGCCCATTTGTCCTAAGAGGGTGGA AGAACAGGGTGAACAAATAAGGTTGACAGAGCTGTCACAGATAACACTCTGGTTTAAAAATATTCAAGTG TGAGTAAACAGGAGCTGAGTGGGCAAGGGCTTTGGAAGGACAAGCAGGACCAGCAGAACATTCCAGATTG GGTGGGTGGAAAACTGGCAAAGAGACCTGAGCCAGAAGAAGAGGCCTTTGTCTCACAGACAAACCACAAA GCCAGGCATTGGAGTCAGAGAGGCAGCAGATGCCAGGCTTGCACCCATCCTTGCGACTGGTCCCCTGGGT GATCTGTCTTCTTCTCTGTCCCTGTAAATAAAGTTTGGGTCTGATCACCATGAGCCTTAGGTATCACTGT GGTGGCTCCCTGAAGCAGACAGCTATGTTTATTTAAAAAGGAGATTTTTTAAGCAGAGAAGAGAAGGATG AATTACCCGGACAGAAAGCAGCTCTGCAGAATAAGACAGCACCTGTGTAATCAGTATTTTTGCCCTCTTT CTCCCATCCCATTCCCTTACCTTGCTATTTCTAGATGCGCCTGGAGAAGGACAGGTTCTCTGTCAACCTG GATGTGAAGCACTTCTCCCCAGAGGAACTCAAAGTTAAGGTGTTGGGAGATGTGATTGAGGTGCATGGAA AACATGAAGAGCGCCAGGTATGTAGCTTGTTTTTTTGTTTTCTGCTCATTCATTCAGTGCATACTGTAAT AGTCCAGGTAGTGCTATCAGCTTTGGAGGCTGGCTACATTCCAGTCCCAAGCCATAACAGTCGGGATCAG GGGTTACAAATCAATGTCTAGAAGACTAAGTTAGGATAGACATATTGCTGTTGTTACTATTATGGCCAGA GATGTGGCCTTTGATTTGATCGCCTTAGATGGGATGATGGGATGCTGATGCCCCATTTAAGCCAGTGGTT CTGAATCTGGGCCACATTAGAATCACCAGGGGAACTTTCAAAAAACCTAATGCTCGGGCATACTCCAGAC CAATTAGCATATGTGCTGCCGAAGCGAGCACTACTCCAGACCAATTAAATCAGCATTTTTAAGGGTGGGA CCCAGGCATCAGCAATTTTTAAGGTAATTCTAATCTACAGTCAAGGTTGAGAACCACTGATTAGGTATAG GGCTGTCAGACACCTAGTTGCTTTGCATAATTACATTAACTACAGGTACCCTAAAAGCACTTGAGTTGTG ACTTCTCTTTTAGCTGTGCAAGAATCCGTGTCTCTTCTTTAGCCCATCTTAATGCTGAACTACTTGGTTT GTCTAAATTTCAGAGCTGTGCTCAGTCTTTAATCCCCTACAGCCCATGTGGTAATCAGTTAACGAGAGCC TGTTTGGCTACATGCTTGAGAGTCAGCAGGCATACGGGTTAAGGTCATCTACTCTTTGGGGGAGTTCTGA CAAATGGAACAGCTTGTTATGACTTTATAAGAGGGCTTTAAAATTGCTTCTCACCATTTAACGATAGCTC AGAACCTGTGCGTCAACCAGTACAGTTTGTCCTCAGTAATGTCCTCAGGCTGTTTCAATTTTGCTTATAT GATTTAGGTTTGGGTCATAGTCTCCTTGGATGGAGTCATTTTTTTTTTTTTTTAATTTCAGCAGCAGTCC TATTGTTCTGGAACCTTCTGGGACATTCCTGAAGAGTCAGGACAATTTCAGGGCTTCCTCAGGGACTCAG ATTCTAAATGAGATTCCAAATTCTGTAGGCCCAGCCAACATTGATCTAAACCTTTGGGAAATACCCCTAA ACATATCTATGCCTCAGGGTTTGAAAAACAATGAAGTGTTGGACTGTTTCAGACTTCTCAGATTCTCACT GGTAGGAGTGACTACCTAGGCAATTTCATCTTAGCTGCAACCCTGAAACGAAGCTCTATTTATTTTTCCT ATGTTGTCATGGCATTTGGTCTCACCTAAGGGGAAATCAGGATGCCTGAGTTCTGGGCAGGTGATAATAG TTCCTGTTCTTATCTCTCTGCCTCTTTCCTCATTCTTTTGGGTTAGGATGAACATGGTTTCATCTCCAGG GAGTTCCACAGGAAATACCGGATCCCAGCTGATGTAGACCCTCTCACCATTACTTCATCCCTGTCATCTG ATGGGGTCCTCACTGTGAATGGACCAAGGAAACAGGTCTCTGGCCCTGAGCGCACCATTCCCATCACCCG TGAAGAGAAGCCTGCTGTCACCGCAGCCCCCAAGAAATAGATGCCCTTTCTTGAATTGCATTTTTTAAAA CAAGAAAGTTTCCCCACCAGTGAATGAAAGTCTTGTGACTAGTGCTGAAGCTTATTAATGCTAAGGGCAG GCCCAAATTATCAAGCTAATAAAATATCATTCAGCAACAGATAA Download Select all
Length	4594
OMIM ID	123590
HGNC ID	HGNC:2389
Unigene ID	Hs.53454
Ensembl ID	ENSG00000109846
PharmGKB ID	-

mRNA Information

mRNA ID	NM_001289807.1
Exon	join(1..75,1292..1690,2765..2887,4247..4594)
mRNA Sequence	>1410 GACCCCTCACACTCACCTAGCCACCATGGACATCGCCATCCACCACCCCTGGATCCGCCGCCCC TTCTTTCCTTTCCACTCCCCCAGCCGCCTCTTTGACCAGTTCTTCGGAGAGCACCTGTTGGAGT CTGATCTTTTCCCGACGTCTACTTCCCTGAGTCCCTTCTACCTTCGGCCACCCTCCTTCCTGCG GGCACCCAGCTGGTTTGACACTGGACTCTCAGAGATGCGCCTGGAGAAGGACAGGTTCTCTGTC AACCTGGATGTGAAGCACTTCTCCCCAGAGGAACTCAAAGTTAAGGTGTTGGGAGATGTGATTG AGGTGCATGGAAAACATGAAGAGCGCCAGGATGAACATGGTTTCATCTCCAGGGAGTTCCACAG GAAATACCGGATCCCAGCTGATGTAGACCCTCTCACCATTACTTCATCCCTGTCATCTGATGGG GTCCTCACTGTGAATGGACCAAGGAAACAGGTCTCTGGCCCTGAGCGCACCATTCCCATCACCC GTGAAGAGAAGCCTGCTGTCACCGCAGCCCCCAAGAAATAGATGCCCTTTCTTGAATTGCATTT TTTAAAACAAGAAAGTTTCCCCACCAGTGAATGAAAGTCTTGTGACTAGTGCTGAAGCTTATTA ATGCTAAGGGCAGGCCCAAATTATCAAGCTAATAAAATATCATTCAGCAAC Download Select all
Length	691

CDS Information

Location	join(1490..1690,2765..2887,4247..4450)
CDS Sequence	>gi\|4503056:26-553 Homo sapiens crystallin, alpha B (CRYAB), mRNA ATGGACATCGCCATCCACCACCCCTGGATCCGCCGCCCCTTCTTTCCTTTCCACTCCCCCAGCCGCCTCT TTGACCAGTTCTTCGGAGAGCACCTGTTGGAGTCTGATCTTTTCCCGACGTCTACTTCCCTGAGTCCCTT CTACCTTCGGCCACCCTCCTTCCTGCGGGCACCCAGCTGGTTTGACACTGGACTCTCAGAGATGCGCCTG GAGAAGGACAGGTTCTCTGTCAACCTGGATGTGAAGCACTTCTCCCCAGAGGAACTCAAAGTTAAGGTGT TGGGAGATGTGATTGAGGTGCATGGAAAACATGAAGAGCGCCAGGATGAACATGGTTTCATCTCCAGGGA GTTCCACAGGAAATACCGGATCCCAGCTGATGTAGACCCTCTCACCATTACTTCATCCCTGTCATCTGAT GGGGTCCTCACTGTGAATGGACCAAGGAAACAGGTCTCTGGCCCTGAGCGCACCATTCCCATCACCCGTG AAGAGAAGCCTGCTGTCACCGCAGCCCCCAAGAAATAG Download Select all
CCDS ID	CCDS8351.1

Protein Information

Protein ID	NP_001276736.1
Protein Name	Crystallin, alpha B
Molecular Wt. (Da)	20028
Protein Sequence	>1410 MDIAIHHPWIRRPFFPFHSPSRLFDQFFGEHLLESDLFPTSTSLSPFYLRPPSFLRAPSWFDTG LSEMRLEKDRFSVNLDVKHFSPEELKVKVLGDVIEVHGKHEERQDEHGFISREFHRKYRIPADV DPLTITSSLSSDGVLTVNGPRKQVSGPERTIPITREEKPAVTAAPKK Download Select all
Length	175
Uniprot ID	O43315
Ensembl Protein ID	ENSP00000219919

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
K	Glycation	166
K	Glycation	174
K	Glycation	175
S	Phosphorylation	19
S	Phosphorylation	21
R	Methylation	22
S	Phosphorylation	43
S	Phosphorylation	45
R	Methylation	50
S	Phosphorylation	53
S	Phosphorylation	59
S	Phosphorylation	76
K	Glycation	82
K	Acetylation	92
T	Glycosylation	170

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING) View

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
1409	CRYAA	427	NP_000385.1	in vitro	11700327
1431	CS	349	NP_004068.2	in vitro	11377425

Pathway Information

Pathway Name	Pathway ID
Longevity regulating pathway - multiple species	hsa04213
Protein processing in endoplasmic reticulum	hsa04141

Structure Information

No matching records could be found.

Domain Information

ID	Location	Description
cd06498	67-150	ACD_alphaB-crystallin_HspB5
cl00175	67-150	alpha-crystallin-Hsps_p23-like superfamily
cd06478	67-149	ACD_HspB4-5-6
cd06526	71-149	metazoan_ACD
cd06497	64-149	ACD_alphaA-crystallin_HspB4
cd06475	64-148	ACD_HspB1_like
pfam00011	67-162	HSP20
pfam00525	Jan-59	Crystallin
cl02890	Jan-59	Crystallin superfamily
cd06476	71-149	ACD_HspB2_like
cd06464	71-149	ACD_sHsps-like
cd06480	75-149	ACD_HspB8_like
cd00298	60-149	ACD_sHsps_p23-like
cd06481	71-149	ACD_HspB9_like
cd06479	73-149	ACD_HspB7_like
cd06477	71-147	ACD_HspB3_Like
cd06482	79-148	ACD_HspB10
cd06470	69-146	ACD_IbpA-B_like
cd06471	73-148	ACD_LpsHSP_like
COG0071	11-161	IbpA

Ontology Information

HPRD ID	4223
Molecular Class	Heat shock protein
Molecular Function	Water channel activity (GO:0015250)
Biological Process	Transport (GO:0006810)

SNP Information

View SNP Geneview Report