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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| VCAN | 1462 | Versican | 5 | WGN; ERVR; GHAP; PG-M; WGN1; CSPG2 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20089989 | 2010 | Cell line : - Source : VU University Medical Center, Amsterdam, The Netherlands. Sample Type : CRC tumor and Normal tissue No. of Sample : - Stage : - | Biochemical isolation to nano-LC-MS/MS analysis | Up-regulation | - | This genes are differenitially expressed between colorectal adenoma and Colorectal cancer tissue. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Immunoglobulin superfamily / V-set domain containing, Proteoglycans / Extracellular Matrix : Hyalectans |
| Description | This gene is a member of the aggrecan/versican proteoglycan family. The protein encoded is a large chondroitin sulfate proteoglycan and is a major component of the extracellular matrix. This protein is involved in cell adhesion, proliferation, proliferation, migration and angiogenesis and plays a central role in tissue morphogenesis and maintenance. Mutations in this gene are the cause of Wagner syndrome type 1. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009] |
| Chromosome | 5 |
| Location | 5q14.3 |
| Start | 83471674 |
| End | 83582303 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 110630 |
| OMIM ID | 118661 |
| HGNC ID | HGNC:2464 |
| Unigene ID | Hs.643801 |
| Ensembl ID | ENSG00000038427 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_004385.4 |
|---|---|
| Exon | join(1..350,11840..11915,18425..18799,21873..22047, 22131..22258,40430..40723,65334..70595,73864..73977, 76298..76411,81691..81849,83283..83365,100743..100887, 108307..108489,108634..110630) | mRNA Sequence | Download Select all |
| Length | 12416 |
CDS Information
| Location | join(11846..11915,18425..18799,21873..22047,22131..22258, 40430..40723,47676..50636,65334..70595,73864..73977, 76298..76411,81691..81849,83283..83365,100743..100887, 108307..108489,108634..108761) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS4060.1 |
Protein Information
| Protein ID | NP_004376.2 |
|---|---|
| Protein Name | Versican |
| Molecular Wt. (Da) | 370518 |
| Protein Sequence | Download Select all |
| Length | 3396 |
| Uniprot ID | P10398 |
| Ensembl Protein ID | ENSP00000366238 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| E | Proteolytic Cleavage | 1428 |
| T | Phosphorylation | 2086 |
| S | Phosphorylation | 2099 |
| S | Phosphorylation | 2116 |
| S | Phosphorylation | 2112 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 960 | CD44 | 115 | NP_000601.3 | in vitro | 10950950 |
| 1404 | HAPLN1 | 275 | NP_001875.1 | in vitro | 12888576 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Cell adhesion molecules (CAMs) | hsa04514 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd03588 | 3169-3292 | CLECT_CSPGs |
| cl02432 | 3169-3292 | CLECT superfamily |
| cd05901 | 36-151 | Ig_Versican |
| cl11960 | 36-151 | Ig superfamily |
| cd03520 | 251-346 | Link_domain_CSPGs_modules_2_4 |
| cl02612 | 251-346 | Link_Domain superfamily |
| cd03517 | 150-244 | Link_domain_CSPGs_modules_1_3 |
| cl02612 | 150-244 | Link_Domain superfamily |
| cd00054 | 3127-3163 | EGF_CA |
| cl21504 | 3127-3163 | EGF_CA superfamily |
| cd00054 | 3091-3125 | EGF_CA |
| cl21504 | 3091-3125 | EGF_CA superfamily |
| cd00033 | 3296-3352 | CCP |
| cl00043 | 3296-3352 | CCP superfamily |
| cd05878 | 36-151 | Ig_Aggrecan_like |
| pfam00193 | 150-244 | Xlink |
| pfam00193 | 251-346 | Xlink |
| smart00445 | 249-347 | LINK |
| smart00445 | 148-244 | LINK |
| cd05714 | 36-151 | Ig_CSPGs_LP |
| cd03590 | 3169-3291 | CLECT_DC-SIGN_like |
| smart00034 | 3169-3290 | CLECT |
| cd03589 | 3169-3290 | CLECT_CEL-1_like |
| cd00037 | 3180-3291 | CLECT |
| cd01102 | 150-244 | Link_Domain |
| cd03518 | 150-244 | Link_domain_HAPLN_module_1 |
| cd01102 | 252-346 | Link_Domain |
| cd05902 | 36-151 | Ig_Neurocan |
| cd03594 | 3169-3290 | CLECT_REG-1_like |
| cd03519 | 252-346 | Link_domain_HAPLN_module_2 |
| cd03518 | 260-346 | Link_domain_HAPLN_module_1 |
| pfam00059 | 3187-3291 | Lectin_C |
| cd03519 | 163-244 | Link_domain_HAPLN_module_2 |
| cd05900 | 36-151 | Ig_Aggrecan |
| cd03515 | 151-244 | Link_domain_TSG_6_like |
| cd05877 | 38-151 | Ig_LP_like |
| cd03603 | 3181-3283 | CLECT_VCBS |
| cd03592 | 3181-3289 | CLECT_selectins_like |
| cd03591 | 3182-3289 | CLECT_collectin_like |
| cd03515 | 252-346 | Link_domain_TSG_6_like |
| cd03593 | 3169-3291 | CLECT_NK_receptors_like |
| cd03595 | 3176-3290 | CLECT_chondrolectin_like |
| cd03598 | 3178-3289 | CLECT_EMBP_like |
| smart00179 | 3127-3163 | EGF_CA |
| cd00053 | 3096-3125 | EGF |
| cd03601 | 3220-3291 | CLECT_TC14_like |
| smart00032 | 3296-3352 | CCP |
| cd03516 | 159-244 | Link_domain_CD44_like |
| cd03602 | 3187-3282 | CLECT_1 |
| pfam00084 | 3296-3352 | Sushi |
| smart00179 | 3093-3125 | EGF_CA |
| cd03516 | 252-380 | Link_domain_CD44_like |
| cd03596 | 3175-3289 | CLECT_tetranectin_like |
| cd00053 | 3130-3163 | EGF |
| cd03600 | 3177-3290 | CLECT_thrombomodulin_like |
| pfam00008 | 3093-3123 | EGF |
| cd03521 | 163-243 | Link_domain_KIAA0527_like |
| smart00181 | 3096-3125 | EGF |
| pfam00008 | 3131-3159 | EGF |
| cd03521 | 263-345 | Link_domain_KIAA0527_like |
| smart00406 | 40-132 | IGv |
| pfam12947 | 3098-3122 | EGF_3 |
| smart00181 | 3130-3163 | EGF |
| cd03597 | 3169-3261 | CLECT_attractin_like |
| pfam07645 | 3127-3157 | EGF_CA |
| smart00410 | 29-147 | IG_like |
| PHA02642 | 3168-3244 | PHA02642 |
| TIGR00864 | 3158-3290 | PCC |
| smart00409 | 29-147 | IG |
| PHA03097 | 3169-3238 | PHA03097 |
Ontology Information
| HPRD ID | 2405 |
|---|---|
| Molecular Class | Extracellular matrix protein |
| Molecular Function | Protein serine/threonine kinase activity (GO:0004674) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P13611 | DB08818 | Hyaluronic acid | SmallMoleculeDrug |