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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
VCAN 1462 Versican  5WGN; ERVR; GHAP; PG-M; WGN1; CSPG2 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
20089989   2010Cell line : -

Source : VU University Medical Center, Amsterdam, The Netherlands.

Sample Type : CRC tumor and Normal tissue

No. of Sample : -

Stage : -

Biochemical isolation to nano-LC-MS/MS analysis Up-regulation-This genes are differenitially expressed between colorectal adenoma and Colorectal cancer tissue.


Gene Details



Chromosome: 5; NC_000005.9 (82767493..82878122)

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Gene Type protein coding
Gene Family Immunoglobulin superfamily / V-set domain containing, Proteoglycans / Extracellular Matrix : Hyalectans
Description This gene is a member of the aggrecan/versican proteoglycan family. The protein encoded is a large chondroitin sulfate proteoglycan and is a major component of the extracellular matrix. This protein is involved in cell adhesion, proliferation, proliferation, migration and angiogenesis and plays a central role in tissue morphogenesis and maintenance. Mutations in this gene are the cause of Wagner syndrome type 1. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]  
Chromosome 5
Location 5q14.3
Start 83471674  
End 83582303  
Strand +  
Gene Sequence

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Length 110630  
OMIM ID 118661   
HGNC ID HGNC:2464   
Unigene ID Hs.643801   
Ensembl ID ENSG00000038427   
PharmGKB ID -   

mRNA Information


mRNA ID NM_004385.4
Exon join(1..350,11840..11915,18425..18799,21873..22047, 22131..22258,40430..40723,65334..70595,73864..73977, 76298..76411,81691..81849,83283..83365,100743..100887, 108307..108489,108634..110630)  
mRNA Sequence

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Length 12416  



CDS Information


   
Location join(11846..11915,18425..18799,21873..22047,22131..22258, 40430..40723,47676..50636,65334..70595,73864..73977, 76298..76411,81691..81849,83283..83365,100743..100887, 108307..108489,108634..108761)
CDS Sequence

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CCDS ID CCDS4060.1



Protein Information


      
Protein IDNP_004376.2
Protein NameVersican
Molecular Wt. (Da)370518
Protein Sequence

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Length 3396  
Uniprot IDP10398
Ensembl Protein ID ENSP00000366238  



Post-translational Modification Information (Source : HPRD)


Residue Type site
EProteolytic Cleavage1428
TPhosphorylation2086
SPhosphorylation2099
SPhosphorylation2116
SPhosphorylation2112

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                              
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
960CD44115NP_000601.3in vitro10950950   
1404HAPLN1275NP_001875.1in vitro12888576   


Pathway Information


      
Pathway Name Pathway ID
Cell adhesion molecules (CAMs) hsa04514


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd035883169-3292  CLECT_CSPGs
cl024323169-3292  CLECT superfamily
cd0590136-151  Ig_Versican
cl1196036-151  Ig superfamily
cd03520251-346  Link_domain_CSPGs_modules_2_4
cl02612251-346  Link_Domain superfamily
cd03517150-244  Link_domain_CSPGs_modules_1_3
cl02612150-244  Link_Domain superfamily
cd000543127-3163  EGF_CA
cl215043127-3163  EGF_CA superfamily
cd000543091-3125  EGF_CA
cl215043091-3125  EGF_CA superfamily
cd000333296-3352  CCP
cl000433296-3352  CCP superfamily
cd0587836-151  Ig_Aggrecan_like
pfam00193150-244  Xlink
pfam00193251-346  Xlink
smart00445249-347  LINK
smart00445148-244  LINK
cd0571436-151  Ig_CSPGs_LP
cd035903169-3291  CLECT_DC-SIGN_like
smart000343169-3290  CLECT
cd035893169-3290  CLECT_CEL-1_like
cd000373180-3291  CLECT
cd01102150-244  Link_Domain
cd03518150-244  Link_domain_HAPLN_module_1
cd01102252-346  Link_Domain
cd0590236-151  Ig_Neurocan
cd035943169-3290  CLECT_REG-1_like
cd03519252-346  Link_domain_HAPLN_module_2
cd03518260-346  Link_domain_HAPLN_module_1
pfam000593187-3291  Lectin_C
cd03519163-244  Link_domain_HAPLN_module_2
cd0590036-151  Ig_Aggrecan
cd03515151-244  Link_domain_TSG_6_like
cd0587738-151  Ig_LP_like
cd036033181-3283  CLECT_VCBS
cd035923181-3289  CLECT_selectins_like
cd035913182-3289  CLECT_collectin_like
cd03515252-346  Link_domain_TSG_6_like
cd035933169-3291  CLECT_NK_receptors_like
cd035953176-3290  CLECT_chondrolectin_like
cd035983178-3289  CLECT_EMBP_like
smart001793127-3163  EGF_CA
cd000533096-3125  EGF
cd036013220-3291  CLECT_TC14_like
smart000323296-3352  CCP
cd03516159-244  Link_domain_CD44_like
cd036023187-3282  CLECT_1
pfam000843296-3352  Sushi
smart001793093-3125  EGF_CA
cd03516252-380  Link_domain_CD44_like
cd035963175-3289  CLECT_tetranectin_like
cd000533130-3163  EGF
cd036003177-3290  CLECT_thrombomodulin_like
pfam000083093-3123  EGF
cd03521163-243  Link_domain_KIAA0527_like
smart001813096-3125  EGF
pfam000083131-3159  EGF
cd03521263-345  Link_domain_KIAA0527_like
smart0040640-132  IGv
pfam129473098-3122  EGF_3
smart001813130-3163  EGF
cd035973169-3261  CLECT_attractin_like
pfam076453127-3157  EGF_CA
smart0041029-147  IG_like
PHA026423168-3244  PHA02642
TIGR008643158-3290  PCC
smart0040929-147  IG
PHA030973169-3238  PHA03097


Ontology Information


   
HPRD ID2405
Molecular ClassExtracellular matrix protein
Molecular FunctionProtein serine/threonine kinase activity (GO:0004674)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
P13611DB08818Hyaluronic acidSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO