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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CTNNA1 | 1495 | Catenin (cadherin-associated protein), alpha 1, 102kDa | 5 | CAP102 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 9137497 | 1997 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Western blotting and immunohistochemistry | Down-regulation | - | Alterations in the levels of both catenins and E-cadherin within tumour tissue may lead to increased cancer cell invasive potential and thus could play a role in the initiation of the early stages of metastatic spread.
|
| 9216695 | 1997 | Cell line : - Source : - Sample Type : CRC tumor and Normal tissue No. of Sample : 94 Stage : TNM Stage I-IV | Immunohistochemistry technique | Down-regulation | - | Carcinomas displayed significantly reduced expression of the cadherin/catenin complex compared with their associated adenomas. The results directly confirm that colorectal tumour progression and invasion is associated with disruption of the cadherin/catenin complex . |
| 9624037 | 1998 | Cell line : - Source : - Sample Type : CRC tumor and Normal tissue No. of Sample : 82 CRC,10 adenomas, 10 lymph nodes, and 3 liver metastases Stage : TNM Stage I-IV | Immunohistochemistry | Down-regulation | - | Alpha-catenin may be a useful marker of invasiveness, metastatic potential, and survival in colorectal cancer patients. Significant down-regulation of alpha-catenin expression in colorectal cancer which is associated with poor differentiation, higher metastatic potential and unfavorable prognosis. |
| 20089989 | 2010 | Cell line : - Source : VU University Medical Center, Amsterdam, The Netherlands. Sample Type : CRC tumor and Normal tissue No. of Sample : - Stage : - | Biochemical isolation to nano-LC-MS/MS analysis. | Down-regulation | - | - |
| 10023666 | 1999 | Cell line : HCT 15, DLD 1, HRT 18,HCT 8 Source : - Sample Type : - No. of Sample : - Stage : - | RNA isolation and Northern blotting, RT-PCR, Immunoprecipitation, Western blotting and immunocytochemistry | Mutation | - | CTNNA1 acts as an invasion-suppressor gene in human colon cancer cells. Show here that one allele of the alphaE-catenin (CTNNA1) gene is mutated in the human colon cancer cell family HCT-8, which is identical to HCT-15, DLD-1 and HRT-18,HCT-8 colon cancer cell line were used in this study. |
| 12218077 | 2002 | Cell line : SW 480, SW 620, HCT 116, HT 29, and Caco 2 Source : - Sample Type : CRC tumor and Normal tissue No. of Sample : 15 CRA, 30 CRC, 13 lymph node metastases Stage : TNM Stage I-III | Immunohistochemistry, confocal fluorescence microscopy, and Western blotting. | Nucleus localisation | - | The E-cadherin/catenin complex plays a major role in epithelial cell-cell adhesion. The expression of alpha-catenin was also studied by immunohistochemistry. CTNNA1 can localize to the nuclei of colorectal tumor cells. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | - |
| Chromosome | 5 |
| Location | 5q31.2 |
| Start | 138753396 |
| End | 138935034 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 181639 |
| OMIM ID | 116805 |
| HGNC ID | HGNC:2509 |
| Unigene ID | Hs.534797 |
| Ensembl ID | ENSG00000044115 |
| PharmGKB ID | PA27008 |
mRNA Information
| mRNA ID | XM_011543787.1 |
|---|---|
| Exon | complement(128..702) | mRNA Sequence | Download Select all |
| Length | 3778 |
Protein Information
| Protein ID | NP_001277236.1 |
|---|---|
| Protein Name | Catenin (cadherin-associated protein), alpha 1, 102kDa |
| Molecular Wt. (Da) | 92591 |
| Protein Sequence | Download Select all |
| Length | 841 |
| Uniprot ID | P61586 |
| Ensembl Protein ID | ENSP00000400175 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| T | Phosphorylation | 658 |
| S | Phosphorylation | 641 |
| Y | Phosphorylation | 177;- |
| Y | Phosphorylation | 619;- |
| T | Phosphorylation | 634 |
| S | Phosphorylation | 652 |
| T | Phosphorylation | 654 |
| S | Phosphorylation | 655 |
| K | Acetylation | 842 |
| K | Acetylation | 186 |
| K | Acetylation | 181 |
| T | Phosphorylation | 645 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 87 | ACTN1 | 20 | NP_001123476.1 | in vivo | 7790378 |
| 999 | CDH1 | 1885 | BAA88957.1 | in vitro;in vivo | 112 262 487 542 250 |
| 1000 | CDH2 | 226 | NP_001783.2 | in vitro | 12604612 |
| 1001 | CDH3 | 227 | NP_001784.2 | in vivo | 1 924 379 822 721 410 000 000 |
| 1013 | CDH15 | 225 | NP_004924.1 | in vitro | 9168809 |
| 1739 | DLG1 | 3007 | NP_004078.2 | in vitro | 9512503 |
| 5663 | PSEN1 | 87 | NP_000012.1 | in vivo | 10635315 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Adherens junction | hsa04520 |
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | hsa05412 |
| Bacterial invasion of epithelial cells | hsa05100 |
| Endometrial cancer | hsa05213 |
| Hippo signaling pathway | hsa04390 |
| Leukocyte transendothelial migration | hsa04670 |
| Pathways in cancer | hsa05200 |
| Tight junction | hsa04530 |
Structure Information
| PDB ID | 1H6G |
|---|---|
| Resolution | 2.2 |
| Method | X-RAY DIFFRACTION |
| Chains | A,B |
| Molecule | ALPHA-1 CATENIN |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam01044 | 19-867 | Vinculin |
| cl20213 | 19-867 | Vinculin superfamily |
| COG1223 | 526-592 | COG1223 |
| TIGR00998 | 1-138 | 8a0101 |
Ontology Information
| HPRD ID | 1323 |
|---|---|
| Molecular Class | Cytoskeletal protein |
| Molecular Function | GTPase activity (GO:0003924) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.