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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
CYP19A1 1588 cytochrome P450 family 19 subfamily A member 1p  15ARO; ARO1; CPV1; CYAR; CYP19; CYPXIX; P-450AROM 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
21479914   2011Cell line : -

Source : Twin Cities Metropolitan Area, Kaiser Permanente Medical Care Program of Northern California (KPMCP) and a seven-county area of Utah.

Sample Type : Population based case control study

No. of Sample : colon cancer cases (n = 1,593) and controls (n = 1,994)

Stage : -

TagSNP selection and genotypingPolymorhpism-CYP19A1 in the development of colon and rectal cancer and that estrogen may influence risk through an inflammation-related mechanism.


Gene Details



NC_000015.9 (51500254..51630795, complement)

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Gene Type protein coding
Gene Family Cytochrome P450 family 19
Description This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]  
Chromosome 15
Location 15q21.1
Start 51500254  
End 51630795  
Strand -  
Gene Sequence

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Length 130542  
OMIM ID 107910   
HGNC ID HGNC:2594   
Unigene ID -   
Ensembl ID ENSG00000137869   
PharmGKB ID -   

mRNA Information


mRNA ID ?NM_000103.3
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS10139.1



Protein Information


      
Protein ID
Protein Namecytochrome P450 family 19 subfamily A member 1p
Molecular Wt. (Da)0
Protein Sequence

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Length 0  
Uniprot IDO00329
Ensembl Protein ID ENSP00000366563  



Post-translational Modification Information (Source : HPRD)


Residue Type site
YPhosphorylation220
YPhosphorylation220
TPhosphorylation392
TPhosphorylation392
TPhosphorylation162
TPhosphorylation162

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

No matching records from HPRD source could be found.

Pathway Information


                  
Pathway Name Pathway ID
Metabolic pathways hsa01100
Ovarian steroidogenesis hsa04913
Steroid hormone biosynthesis hsa00140


Structure Information


No matching records could be found.

Domain Information




ID Location Description
pfam0006748-485  p450
cl1207848-485  p450 superfamily
COG212479-458  CypX
PLN02936230-468  PLN02936
PLN02655232-497  PLN02655
PLN02426304-461  PLN02426
PLN02290243-458  PLN02290
PTZ0040477-489  PTZ00404
PLN03195234-469  PLN03195
PLN0323478-483  PLN03234
PLN0296677-465  PLN02966
PLN02394242-480  PLN02394
PLN02500241-459  PLN02500
PLN03112242-459  PLN03112
PLN0216988-474  PLN02169
PLN02196244-460  PLN02196
PLN02687242-481  PLN02687
PLN00168294-473  PLN00168
PLN02971259-479  PLN02971
PLN02987214-458  PLN02987
TIGR04538300-459  P450_cycloAA_1
PLN00110291-465  PLN00110
PLN02183240-458  PLN02183
PLN02302244-467  PLN02302
PLN03141240-439  PLN03141
PLN03018298-465  PLN03018
PLN02774286-458  PLN02774
TIGR04458356-458  CYP450_TxtE
PLN02648277-391  PLN02648
PLN0273880-465  PLN02738


Ontology Information


   
HPRD ID1381
Molecular ClassNot Available
Molecular FunctionReceptor signaling complex scaffold activity (GO:0030159)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
P11511DB00072TrastuzumabBiotechDrug
P11511DB00255DiethylstilbestrolSmallMoleculeDrug
P11511DB00257ClotrimazoleSmallMoleculeDrug
P11511DB00292EtomidateSmallMoleculeDrug
P11511DB00333MethadoneSmallMoleculeDrug
P11511DB00358MefloquineSmallMoleculeDrug
P11511DB00367LevonorgestrelSmallMoleculeDrug
P11511DB00389CarbimazoleSmallMoleculeDrug
P11511DB00443BetamethasoneSmallMoleculeDrug
P11511DB00481RaloxifeneSmallMoleculeDrug
P11511DB00624TestosteroneSmallMoleculeDrug
P11511DB00675TamoxifenSmallMoleculeDrug
P11511DB00856ChlorphenesinSmallMoleculeDrug
P11511DB00857TerbinafineSmallMoleculeDrug
P11511DB00858DrostanoloneSmallMoleculeDrug
P11511DB00882ClomifeneSmallMoleculeDrug
P11511DB00917DinoprostoneSmallMoleculeDrug
P11511DB00974Edetic AcidSmallMoleculeDrug
P11511DB00984Nandrolone phenpropionateSmallMoleculeDrug
P11511DB00990ExemestaneSmallMoleculeDrug
P11511DB01006LetrozoleSmallMoleculeDrug
P11511DB01007TioconazoleSmallMoleculeDrug
P11511DB01065MelatoninSmallMoleculeDrug
P11511DB01110MiconazoleSmallMoleculeDrug
P11511DB01127EconazoleSmallMoleculeDrug
P11511DB01217AnastrozoleSmallMoleculeDrug
P11511DB01227Levomethadyl AcetateSmallMoleculeDrug
P11511DB01229PaclitaxelSmallMoleculeDrug
P11511DB01234DexamethasoneSmallMoleculeDrug
P11511DB01406DanazolSmallMoleculeDrug
P11511DB04794BifonazoleSmallMoleculeDrug
P11511DB04839Cyproterone acetateSmallMoleculeDrug
P11511DB06147SulfathiazoleSmallMoleculeDrug
P11511DB06710MethyltestosteroneSmallMoleculeDrug
P11511DB06719BuserelinBiotechDrug
P11511DB08804Nandrolone decanoateSmallMoleculeDrug
P11511DB00184NicotineSmallMoleculeDrug
P11511DB00357AminoglutethimideSmallMoleculeDrug
P11511DB00894TestolactoneSmallMoleculeDrug
P11511DB00990ExemestaneSmallMoleculeDrug
P11511DB01006LetrozoleSmallMoleculeDrug
P11511DB01026KetoconazoleSmallMoleculeDrug
P11511DB01217AnastrozoleSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO