Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CYP19A1 | 1588 | cytochrome P450 family 19 subfamily A member 1p  | 15 | ARO; ARO1; CPV1; CYAR; CYP19; CYPXIX; P-450AROM  |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21479914    | 2011 | Cell line : - Source : Twin Cities Metropolitan Area, Kaiser Permanente Medical Care Program of Northern California (KPMCP) and a seven-county area of Utah. Sample Type : Population based case control study No. of Sample : colon cancer cases (n = 1,593) and controls (n = 1,994) Stage : - | TagSNP selection and genotyping | Polymorhpism | - | CYP19A1 in the development of colon and rectal cancer and that estrogen may influence risk through an inflammation-related mechanism. |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | Cytochrome P450 family 19 |
| Description | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]   | Chromosome | 15 |
| Location | 15q21.1 |
| Start | 51500254   |
| End | 51630795   |
| Strand | -   |
| Gene Sequence |    Download   Select all |
| Length | 130542   |
| OMIM ID | 107910    |
| HGNC ID | HGNC:2594    |
| Unigene ID | -    |
| Ensembl ID | ENSG00000137869    |
| PharmGKB ID | -    |
mRNA Information
| mRNA ID | ?NM_000103.3 |
|---|---|
| Exon |   | mRNA Sequence |    Download   Select all |
| Length |   |
CDS Information
| Location | |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | CCDS10139.1 |    
Protein Information
| Protein ID | |
|---|---|
| Protein Name | cytochrome P450 family 19 subfamily A member 1p |
| Molecular Wt. (Da) | 0 |
| Protein Sequence |    Download   Select all |
| Length | 0   |
| Uniprot ID | O00329 |    
| Ensembl Protein ID | ENSP00000366563   |    
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 220 |
| Y | Phosphorylation | 220 |
| T | Phosphorylation | 392 |
| T | Phosphorylation | 392 |
| T | Phosphorylation | 162 |
| T | Phosphorylation | 162 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Metabolic pathways |    hsa01100 |    
| Ovarian steroidogenesis |    hsa04913 |    
| Steroid hormone biosynthesis |    hsa00140 |    
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00067 | 48-485  | p450 |
| cl12078 | 48-485  | p450 superfamily |
| COG2124 | 79-458  | CypX |
| PLN02936 | 230-468  | PLN02936 |
| PLN02655 | 232-497  | PLN02655 |
| PLN02426 | 304-461  | PLN02426 |
| PLN02290 | 243-458  | PLN02290 |
| PTZ00404 | 77-489  | PTZ00404 |
| PLN03195 | 234-469  | PLN03195 |
| PLN03234 | 78-483  | PLN03234 |
| PLN02966 | 77-465  | PLN02966 |
| PLN02394 | 242-480  | PLN02394 |
| PLN02500 | 241-459  | PLN02500 |
| PLN03112 | 242-459  | PLN03112 |
| PLN02169 | 88-474  | PLN02169 |
| PLN02196 | 244-460  | PLN02196 |
| PLN02687 | 242-481  | PLN02687 |
| PLN00168 | 294-473  | PLN00168 |
| PLN02971 | 259-479  | PLN02971 |
| PLN02987 | 214-458  | PLN02987 |
| TIGR04538 | 300-459  | P450_cycloAA_1 |
| PLN00110 | 291-465  | PLN00110 |
| PLN02183 | 240-458  | PLN02183 |
| PLN02302 | 244-467  | PLN02302 |
| PLN03141 | 240-439  | PLN03141 |
| PLN03018 | 298-465  | PLN03018 |
| PLN02774 | 286-458  | PLN02774 |
| TIGR04458 | 356-458  | CYP450_TxtE |
| PLN02648 | 277-391  | PLN02648 |
| PLN02738 | 80-465  | PLN02738 |
Ontology Information
| HPRD ID | 1381 |    
|---|---|
| Molecular Class | Not Available |
| Molecular Function | Receptor signaling complex scaffold activity (GO:0030159) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165)   |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P11511 | DB00072 | Trastuzumab | BiotechDrug |
| P11511 | DB00255 | Diethylstilbestrol | SmallMoleculeDrug |
| P11511 | DB00257 | Clotrimazole | SmallMoleculeDrug |
| P11511 | DB00292 | Etomidate | SmallMoleculeDrug |
| P11511 | DB00333 | Methadone | SmallMoleculeDrug |
| P11511 | DB00358 | Mefloquine | SmallMoleculeDrug |
| P11511 | DB00367 | Levonorgestrel | SmallMoleculeDrug |
| P11511 | DB00389 | Carbimazole | SmallMoleculeDrug |
| P11511 | DB00443 | Betamethasone | SmallMoleculeDrug |
| P11511 | DB00481 | Raloxifene | SmallMoleculeDrug |
| P11511 | DB00624 | Testosterone | SmallMoleculeDrug |
| P11511 | DB00675 | Tamoxifen | SmallMoleculeDrug |
| P11511 | DB00856 | Chlorphenesin | SmallMoleculeDrug |
| P11511 | DB00857 | Terbinafine | SmallMoleculeDrug |
| P11511 | DB00858 | Drostanolone | SmallMoleculeDrug |
| P11511 | DB00882 | Clomifene | SmallMoleculeDrug |
| P11511 | DB00917 | Dinoprostone | SmallMoleculeDrug |
| P11511 | DB00974 | Edetic Acid | SmallMoleculeDrug |
| P11511 | DB00984 | Nandrolone phenpropionate | SmallMoleculeDrug |
| P11511 | DB00990 | Exemestane | SmallMoleculeDrug |
| P11511 | DB01006 | Letrozole | SmallMoleculeDrug |
| P11511 | DB01007 | Tioconazole | SmallMoleculeDrug |
| P11511 | DB01065 | Melatonin | SmallMoleculeDrug |
| P11511 | DB01110 | Miconazole | SmallMoleculeDrug |
| P11511 | DB01127 | Econazole | SmallMoleculeDrug |
| P11511 | DB01217 | Anastrozole | SmallMoleculeDrug |
| P11511 | DB01227 | Levomethadyl Acetate | SmallMoleculeDrug |
| P11511 | DB01229 | Paclitaxel | SmallMoleculeDrug |
| P11511 | DB01234 | Dexamethasone | SmallMoleculeDrug |
| P11511 | DB01406 | Danazol | SmallMoleculeDrug |
| P11511 | DB04794 | Bifonazole | SmallMoleculeDrug |
| P11511 | DB04839 | Cyproterone acetate | SmallMoleculeDrug |
| P11511 | DB06147 | Sulfathiazole | SmallMoleculeDrug |
| P11511 | DB06710 | Methyltestosterone | SmallMoleculeDrug |
| P11511 | DB06719 | Buserelin | BiotechDrug |
| P11511 | DB08804 | Nandrolone decanoate | SmallMoleculeDrug |
| P11511 | DB00184 | Nicotine | SmallMoleculeDrug |
| P11511 | DB00357 | Aminoglutethimide | SmallMoleculeDrug |
| P11511 | DB00894 | Testolactone | SmallMoleculeDrug |
| P11511 | DB00990 | Exemestane | SmallMoleculeDrug |
| P11511 | DB01006 | Letrozole | SmallMoleculeDrug |
| P11511 | DB01026 | Ketoconazole | SmallMoleculeDrug |
| P11511 | DB01217 | Anastrozole | SmallMoleculeDrug |
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
