Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| DCC | 1630 | Deleted in colorectal carcinoma  | 18 | CRC18; CRCR1; MRMV1; IGDCC1  |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 19242752    | 2009 | Cell line : - Source : - Sample Type : CRC tumor and Normal tissue No. of Sample : 50 Stage : TNM Stage I-IV | Methylation specific-PCR | Methylation | - | Aberrant methylation of the netrin-1 receptor genes UNC5C and DCC detected in advanced colorectal cancer. Netrin-1 receptors (UNC5C and DCC) might act as a tumor suppressor in colorectal cancers, and thus methylation might present a malignant potential in colorectal cancer. |
| 19329758    | 2009 | Cell line : CACO 2, COLO 205, HT 29, SW 480, HCT 116, RKO and LS174T and SW 48 Source : Department of Pathology of the Maastricht University Medical Center. Sample Type : CRC tumor and Normal tissue No. of Sample : CRC tissues 75 and normal tissue 61 of patients Stage : TNM Stage I-IV | Methylation specific-PCR, Sodium bisulfite sequencing and Multiplex ligation-dependent probe amplification. | Methylation | - | DCC has promoter CpG island methylation in CRC cell lines and tissues {normal mucosa [29.5%(18/61)], adenomas [81.0% (47/58)] and carcinomas [82.7% (62/75)] (P = 8.6 x 10(-9))} that is associated with reduced DCC expression, independent of 18q21 loss. |
| 22879877    | 2012 | Cell line : - Source : African-American patients undergoing colonoscopy at Howard University Hospital. Sample Type : CRC tumor and Normal tissue No. of Sample : 30 Stage : TNM Stage I-IV | Array comparative genomic hybridization, MSI analysis, Computational analysis of genes target | Mutation & Deletion | - | DCC (Deleted in Colon Cancer) wasdeleted in 50% of the cases, unlike in Caucasians where it was more frequently amplified than deleted.
|
| 22997602    | 2012 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | - | Mutation & Deletion | - | LOH contribute to the inactivation of tumour suppressor genes such as APC, DCC, SMAD4, and TP53. A common finding in chromosomally instable neoplasms is loss of 18q, a finding identified in up to 70% of primary CRCs and this region contains DCC, SMAD2 and SMAD4 gene. |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | Immunoglobulin superfamily / I-set domain containing, Immunoglobulin superfamily / Immunoglobulin-like domain containing, Fibronectin type III domain containing |
| Description | This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma. [provided by RefSeq, Oct 2009]   |
| Chromosome | 18 |
| Location | 18q21.3 |
| Start | 52340172   |
| End | 53535903   |
| Strand | +   |
| Gene Sequence |    Download   Select all |
| Length | 1195732   |
| OMIM ID | 120470    |
| HGNC ID | HGNC:2701    |
| Unigene ID | Hs.162025    |
| Ensembl ID | ENSG00000187323    |
| PharmGKB ID | -    |
mRNA Information
| mRNA ID | NM_005215.3 |
|---|---|
| Exon | join(1..707,411883..412203,565873..566157,583536..583686, 585063..585199,723134..723288,725875..725995, 817185..817341,838791..838945,865045..865193, 867508..867646,875377..875426,965407..965548, 981876..981986,999542..999736,1045872..1045967, 1051484..1051716,1057137..1057275,1062615..1062722, 1070281..1070475,1075953..1075985,1094973..1095038, 1110329..1110491,1119061..1119287,1127723..1127839, 1146626..1146787,1159127..1159339,1186446..1186588, 1190393..1195732)   | mRNA Sequence |    Download   Select all |
| Length | 10210   |
CDS Information
| Location | join(617..707,411883..412203,565873..566157, 583536..583686,585063..585199,723134..723288, 725875..725995,817185..817341,838791..838945, 865045..865193,867508..867646,875377..875426, 965407..965548,981876..981986,999542..999736, 1045872..1045967,1051484..1051716,1057137..1057275, 1062615..1062722,1070281..1070475,1075953..1075985, 1094973..1095038,11 |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | CCDS11952.1 |    
Protein Information
| Protein ID | NP_005206.2 |
|---|---|
| Protein Name | Deleted in colorectal carcinoma |
| Molecular Wt. (Da) | 158326 |
| Protein Sequence |    Download   Select all |
| Length | 1447   |
| Uniprot ID | P01008 |    
| Ensembl Protein ID | ENSP00000356671   |    
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| D | Proteolytic Cleavage | 1290 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Axon guidance |    hsa04360 |    
| Colorectal cancer |    hsa05210 |    
| Pathways in cancer |    hsa05200 |    
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd05722 | 41-136  | Ig1_Neogenin |
| cl11960 | 41-136  | Ig superfamily |
| cd00063 | 528-617  | FN3 |
| cl21522 | 528-617  | FN3 superfamily |
| cd00063 | 429-521  | FN3 |
| cl21522 | 429-521  | FN3 superfamily |
| cd00063 | 625-715  | FN3 |
| cl21522 | 625-715  | FN3 superfamily |
| cd00063 | 946-1041  | FN3 |
| cl21522 | 946-1041  | FN3 superfamily |
| cd00096 | 157-222  | Ig |
| cl11960 | 157-222  | Ig superfamily |
| cd00063 | 846-939  | FN3 |
| cl21522 | 846-939  | FN3 superfamily |
| cd00063 | 726-814  | FN3 |
| cl21522 | 726-814  | FN3 superfamily |
| cd05723 | 347-417  | Ig4_Neogenin |
| cl11960 | 347-417  | Ig superfamily |
| smart00060 | 625-705  | FN3 |
| cd05728 | 333-417  | Ig4_Contactin-2-like |
| cd05724 | 244-327  | Ig2_Robo |
| cl11960 | 244-327  | Ig superfamily |
| cd00096 | 257-324  | Ig |
| smart00060 | 528-607  | FN3 |
| cd00096 | 348-414  | Ig |
| cd04969 | 345-417  | Ig5_Contactin_like |
| pfam00041 | 529-607  | fn3 |
| pfam00041 | 946-1034  | fn3 |
| pfam00041 | 625-708  | fn3 |
| cd05725 | 348-417  | Ig3_Robo |
| cd05747 | 329-407  | Ig5_Titin_like |
| cd07693 | 41-137  | Ig1_Robo |
| smart00060 | 429-511  | FN3 |
| cd05728 | 242-327  | Ig4_Contactin-2-like |
| smart00060 | 946-1031  | FN3 |
| cd05722 | 241-327  | Ig1_Neogenin |
| cd05764 | 154-223  | Ig_2 |
| cd04978 | 154-217  | Ig4_L1-NrCAM_like |
| cd05724 | 45-136  | Ig2_Robo |
| cd05725 | 157-216  | Ig3_Robo |
| smart00060 | 726-805  | FN3 |
| cd07693 | 330-413  | Ig1_Robo |
| cd05745 | 154-221  | Ig3_Peroxidasin |
| cd05745 | 344-417  | Ig3_Peroxidasin |
| cd05724 | 351-417  | Ig2_Robo |
| cd05722 | 332-405  | Ig1_Neogenin |
| cd05736 | 257-317  | Ig2_Follistatin_like |
| cd05765 | 154-220  | Ig_3 |
| cd05724 | 145-230  | Ig2_Robo |
| cd05851 | 145-216  | Ig3_Contactin-1 |
| pfam13895 | 245-327  | Ig_2 |
| cd05722 | 141-222  | Ig1_Neogenin |
| cd04969 | 254-326  | Ig5_Contactin_like |
| cd05857 | 348-417  | Ig2_FGFR |
| cd04968 | 147-230  | Ig3_Contactin_like |
| cd05746 | 348-415  | Ig4_Peroxidasin |
| cd04968 | 337-417  | Ig3_Contactin_like |
| pfam00041 | 430-514  | fn3 |
| cd05726 | 154-220  | Ig4_Robo |
| cd04967 | 242-313  | Ig1_Contactin |
| cd07693 | 139-216  | Ig1_Robo |
| cd04972 | 334-417  | Ig_TrkABC_d4 |
| cd05731 | 348-410  | Ig3_L1-CAM_like |
| cd05730 | 352-417  | Ig3_NCAM-1_like |
| cd05736 | 352-417  | Ig2_Follistatin_like |
| cd05730 | 244-329  | Ig3_NCAM-1_like |
| cd05728 | 153-230  | Ig4_Contactin-2-like |
| cd04978 | 254-328  | Ig4_L1-NrCAM_like |
| cd04969 | 154-216  | Ig5_Contactin_like |
| cd04978 | 347-417  | Ig4_L1-NrCAM_like |
| cd05763 | 159-224  | Ig_1 |
| cd05748 | 354-417  | Ig_Titin_like |
| cd05738 | 161-230  | Ig2_RPTP_IIa_LAR_like |
| smart00060 | 846-929  | FN3 |
| cd05852 | 351-417  | Ig5_Contactin-1 |
| cd05848 | 242-313  | Ig1_Contactin-5 |
| pfam13895 | 145-230  | Ig_2 |
| cd05867 | 154-216  | Ig4_L1-CAM_like |
| cd05725 | 257-327  | Ig3_Robo |
| cd05757 | 269-329  | Ig2_IL1R_like |
| pfam13927 | 246-314  | Ig_3 |
| cd05851 | 339-417  | Ig3_Contactin-1 |
| pfam07686 | 244-327  | V-set |
| cd05729 | 154-220  | Ig2_FGFR_like |
| pfam00047 | 154-214  | ig |
| cd05747 | 243-327  | Ig5_Titin_like |
| cd04976 | 263-329  | Ig2_VEGFR |
| cd04967 | 331-407  | Ig1_Contactin |
| cd05737 | 246-329  | Ig_Myomesin_like_C |
| cd05729 | 259-327  | Ig2_FGFR_like |
| cd05733 | 157-229  | Ig6_L1-CAM_like |
| cd04967 | 42-132  | Ig1_Contactin |
| cd05856 | 153-218  | Ig2_FGFRL1-like |
| pfam00041 | 846-932  | fn3 |
| cd05732 | 143-217  | Ig5_NCAM-1_like |
| cd05744 | 259-327  | Ig_Myotilin_C_like |
| cd05894 | 246-329  | Ig_C5_MyBP-C |
| cd05849 | 331-412  | Ig1_Contactin-1 |
| cd05736 | 159-218  | Ig2_Follistatin_like |
| cd05849 | 242-313  | Ig1_Contactin-1 |
| cd05729 | 348-407  | Ig2_FGFR_like |
| pfam00047 | 254-312  | ig |
| cd05876 | 351-410  | Ig3_L1-CAM |
| cd05892 | 259-309  | Ig_Myotilin_C |
| cd05735 | 349-423  | Ig8_DSCAM |
| cd05743 | 154-216  | Ig_Perlecan_D2_like |
| cd05747 | 139-227  | Ig5_Titin_like |
| cd05856 | 259-327  | Ig2_FGFRL1-like |
| cd05893 | 259-327  | Ig_Palladin_C |
| cd05848 | 331-407  | Ig1_Contactin-5 |
| cd05746 | 157-217  | Ig4_Peroxidasin |
| cd05731 | 258-329  | Ig3_L1-CAM_like |
| pfam00041 | 727-807  | fn3 |
| pfam00047 | 352-402  | ig |
| cd05726 | 348-417  | Ig4_Robo |
| cd05723 | 157-218  | Ig4_Neogenin |
| cd05763 | 349-417  | Ig_1 |
| cd05734 | 258-313  | Ig7_DSCAM |
| cd05733 | 348-409  | Ig6_L1-CAM_like |
| cd05763 | 257-328  | Ig_1 |
| cd00096 | 57-133  | Ig |
| cd05734 | 157-216  | Ig7_DSCAM |
| cd05891 | 246-329  | Ig_M-protein_C |
| cd05744 | 348-417  | Ig_Myotilin_C_like |
| cd05750 | 258-325  | Ig_Pro_neuregulin |
| cd05748 | 263-329  | Ig_Titin_like |
| cd05868 | 254-328  | Ig4_NrCAM |
| cd05864 | 265-329  | Ig2_VEGFR-2 |
| cd04968 | 46-119  | Ig3_Contactin_like |
| cd05852 | 254-310  | Ig5_Contactin-1 |
| pfam07686 | 145-230  | V-set |
| cd05737 | 352-407  | Ig_Myomesin_like_C |
| cd05893 | 348-417  | Ig_Palladin_C |
| cd05895 | 258-325  | Ig_Pro_neuregulin-1 |
| cd04968 | 244-319  | Ig3_Contactin_like |
| cd05891 | 344-407  | Ig_M-protein_C |
| cd05892 | 348-417  | Ig_Myotilin_C |
| pfam13927 | 348-404  | Ig_3 |
| cd05737 | 149-224  | Ig_Myomesin_like_C |
| pfam09294 | 625-710  | Interfer-bind |
| pfam13895 | 45-136  | Ig_2 |
| cd07702 | 263-329  | Ig2_VEGFR-1 |
| cd05750 | 353-415  | Ig_Pro_neuregulin |
| cd05731 | 157-220  | Ig3_L1-CAM_like |
| cd05760 | 157-220  | Ig2_PTK7 |
| cd05745 | 253-327  | Ig3_Peroxidasin |
| cd05869 | 147-217  | Ig5_NCAM-1 |
| cd05874 | 348-412  | Ig6_NrCAM |
| cd05874 | 157-229  | Ig6_NrCAM |
| cd05891 | 149-216  | Ig_M-protein_C |
| cd05870 | 143-223  | Ig5_NCAM-2 |
| cd04978 | 54-120  | Ig4_L1-NrCAM_like |
| cd05857 | 154-220  | Ig2_FGFR |
| cd05857 | 259-327  | Ig2_FGFR |
| cd05868 | 352-407  | Ig4_NrCAM |
| cd05732 | 339-417  | Ig5_NCAM-1_like |
| cd05875 | 157-229  | Ig6_hNeurofascin_like |
| cd04972 | 143-220  | Ig_TrkABC_d4 |
| cd04979 | 246-311  | Ig_Semaphorin_C |
| cd04974 | 347-417  | Ig3_FGFR |
| cd05730 | 150-218  | Ig3_NCAM-1_like |
| cd05852 | 154-216  | Ig5_Contactin-1 |
| cd05873 | 273-318  | Ig_Sema4D_like |
| cd05867 | 254-328  | Ig4_L1-CAM_like |
| cd05757 | 70-136  | Ig2_IL1R_like |
| pfam12306 | 865-989  | PixA |
| cl20454 | 865-989  | PixA superfamily |
| pfam13895 | 337-417  | Ig_2 |
| cd05850 | 331-407  | Ig1_Contactin-2 |
| cd04977 | 350-410  | Ig1_NCAM-1_like |
| cd05765 | 254-327  | Ig_3 |
| cd04967 | 157-226  | Ig1_Contactin |
| cd05732 | 248-310  | Ig5_NCAM-1_like |
| cd05897 | 273-328  | Ig2_IL1R2_like |
| cd00098 | 242-314  | IgC |
| cd05734 | 57-131  | Ig7_DSCAM |
| cd04970 | 257-331  | Ig6_Contactin_like |
| cd05870 | 248-310  | Ig5_NCAM-2 |
| cd05774 | 246-327  | Ig_CEACAM_D1 |
| cd05894 | 348-417  | Ig_C5_MyBP-C |
| cd05739 | 352-415  | Ig3_RPTP_IIa_LAR_like |
| cd05850 | 157-229  | Ig1_Contactin-2 |
| cd04973 | 147-222  | Ig1_FGFR |
| cd04972 | 243-327  | Ig_TrkABC_d4 |
| cd05717 | 247-327  | Ig1_Necl-1-3_like |
| cd05867 | 54-119  | Ig4_L1-CAM_like |
| cd05850 | 242-313  | Ig1_Contactin-2 |
| pfam06583 | 1146-1445  | Neogenin_C |
| pfam07679 | 331-417  | I-set |
| pfam07679 | 241-327  | I-set |
| smart00408 | 153-219  | IGc2 |
| smart00408 | 54-120  | IGc2 |
| smart00410 | 246-327  | IG_like |
| smart00409 | 246-327  | IG |
| smart00410 | 337-417  | IG_like |
| smart00409 | 337-417  | IG |
| pfam07679 | 141-222  | I-set |
| smart00409 | 147-224  | IG |
| smart00410 | 147-224  | IG_like |
| smart00408 | 347-407  | IGc2 |
| smart00408 | 253-313  | IGc2 |
| PHA03247 | 1168-1416  | PHA03247 |
| smart00410 | 46-136  | IG_like |
| smart00409 | 46-136  | IG |
| pfam03154 | 1158-1414  | Atrophin-1 |
| PTZ00449 | 1142-1365  | PTZ00449 |
| pfam03154 | 1188-1424  | Atrophin-1 |
| PHA02826 | 292-400  | PHA02826 |
| PHA03247 | 1168-1414  | PHA03247 |
| PHA03379 | 1163-1419  | PHA03379 |
| PHA03247 | 1168-1428  | PHA03247 |
| pfam07223 | 1192-1375  | DUF1421 |
| PHA03378 | 1173-1403  | PHA03378 |
| pfam03154 | 1122-1375  | Atrophin-1 |
| pfam07679 | 41-120  | I-set |
| pfam09606 | 1243-1358  | Med15 |
| PRK10263 | 1252-1359  | PRK10263 |
| PHA03377 | 1259-1427  | PHA03377 |
| PRK12323 | 1204-1439  | PRK12323 |
| PRK07003 | 1223-1373  | PRK07003 |
| pfam05109 | 1166-1434  | Herpes_BLLF1 |
| PHA02826 | 206-328  | PHA02826 |
| PHA03247 | 1262-1417  | PHA03247 |
| PHA03378 | 1208-1405  | PHA03378 |
Ontology Information
| HPRD ID | 122 |    
|---|---|
| Molecular Class | Cell surface receptor |
| Molecular Function | Protease inhibitor activity (GO:0030414) |
| Biological Process | Protein metabolism (GO:0019538)   |
Drug Information
No matching records could be found.
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
