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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
DCC 1630 Deleted in colorectal carcinoma  18CRC18; CRCR1; MRMV1; IGDCC1 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
19242752   2009Cell line : -

Source : -

Sample Type : CRC tumor and Normal tissue

No. of Sample : 50

Stage : TNM Stage I-IV

Methylation specific-PCRMethylation-Aberrant methylation of the netrin-1 receptor genes UNC5C and DCC detected in advanced colorectal cancer.

Netrin-1 receptors (UNC5C and DCC) might act as a tumor suppressor in colorectal cancers, and thus methylation might present a malignant potential in colorectal cancer.

19329758   2009Cell line : CACO 2, COLO 205, HT 29, SW 480, HCT 116, RKO and LS174T and SW 48

Source : Department of Pathology of the Maastricht University Medical Center.

Sample Type : CRC tumor and Normal tissue

No. of Sample : CRC tissues 75 and normal tissue 61 of patients

Stage : TNM Stage I-IV

Methylation specific-PCR, Sodium bisulfite sequencing and Multiplex ligation-dependent probe amplification.Methylation-DCC has promoter CpG island methylation in CRC cell lines and tissues {normal mucosa [29.5%(18/61)], adenomas [81.0% (47/58)] and carcinomas [82.7% (62/75)] (P = 8.6 x 10(-9))} that is associated with reduced DCC expression, independent of 18q21 loss.

22879877   2012Cell line : -

Source : African-American patients undergoing colonoscopy at Howard University Hospital.

Sample Type : CRC tumor and Normal tissue

No. of Sample : 30

Stage : TNM Stage I-IV

Array comparative genomic hybridization, MSI analysis, Computational analysis of genes targetMutation & Deletion-DCC (Deleted in Colon Cancer) wasdeleted in 50% of the cases, unlike in Caucasians where it was more frequently amplified than deleted.

22997602   2012Cell line : -

Source : -

Sample Type : -

No. of Sample : -

Stage : -

-Mutation & Deletion-LOH contribute to the inactivation of tumour suppressor genes such as APC, DCC, SMAD4, and TP53.

A common finding in chromosomally instable neoplasms is loss of 18q, a finding identified in up to 70% of primary CRCs and this region contains DCC, SMAD2 and SMAD4 gene.


Gene Details



Chromosome: 18; NC_000018.9 (49866542..51062273)

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Gene Type protein coding
Gene Family Immunoglobulin superfamily / I-set domain containing, Immunoglobulin superfamily / Immunoglobulin-like domain containing, Fibronectin type III domain containing
Description This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma. [provided by RefSeq, Oct 2009]  
Chromosome 18
Location 18q21.3
Start 52340172  
End 53535903  
Strand +  
Gene Sequence

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Length 1195732  
OMIM ID 120470   
HGNC ID HGNC:2701   
Unigene ID Hs.162025   
Ensembl ID ENSG00000187323   
PharmGKB ID -   

mRNA Information


mRNA ID NM_005215.3
Exon join(1..707,411883..412203,565873..566157,583536..583686, 585063..585199,723134..723288,725875..725995, 817185..817341,838791..838945,865045..865193, 867508..867646,875377..875426,965407..965548, 981876..981986,999542..999736,1045872..1045967, 1051484..1051716,1057137..1057275,1062615..1062722, 1070281..1070475,1075953..1075985,1094973..1095038, 1110329..1110491,1119061..1119287,1127723..1127839, 1146626..1146787,1159127..1159339,1186446..1186588, 1190393..1195732)  
mRNA Sequence

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Length 10210  



CDS Information


   
Location join(617..707,411883..412203,565873..566157, 583536..583686,585063..585199,723134..723288, 725875..725995,817185..817341,838791..838945, 865045..865193,867508..867646,875377..875426, 965407..965548,981876..981986,999542..999736, 1045872..1045967,1051484..1051716,1057137..1057275, 1062615..1062722,1070281..1070475,1075953..1075985, 1094973..1095038,11
CDS Sequence

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CCDS ID CCDS11952.1



Protein Information


      
Protein IDNP_005206.2
Protein NameDeleted in colorectal carcinoma
Molecular Wt. (Da)158326
Protein Sequence

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Length 1447  
Uniprot IDP01008
Ensembl Protein ID ENSP00000356671  



Post-translational Modification Information (Source : HPRD)


Residue Type site
DProteolytic Cleavage1290

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

No matching records from HPRD source could be found.

Pathway Information


                  
Pathway Name Pathway ID
Axon guidance hsa04360
Colorectal cancer hsa05210
Pathways in cancer hsa05200


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd0572241-136  Ig1_Neogenin
cl1196041-136  Ig superfamily
cd00063528-617  FN3
cl21522528-617  FN3 superfamily
cd00063429-521  FN3
cl21522429-521  FN3 superfamily
cd00063625-715  FN3
cl21522625-715  FN3 superfamily
cd00063946-1041  FN3
cl21522946-1041  FN3 superfamily
cd00096157-222  Ig
cl11960157-222  Ig superfamily
cd00063846-939  FN3
cl21522846-939  FN3 superfamily
cd00063726-814  FN3
cl21522726-814  FN3 superfamily
cd05723347-417  Ig4_Neogenin
cl11960347-417  Ig superfamily
smart00060625-705  FN3
cd05728333-417  Ig4_Contactin-2-like
cd05724244-327  Ig2_Robo
cl11960244-327  Ig superfamily
cd00096257-324  Ig
smart00060528-607  FN3
cd00096348-414  Ig
cd04969345-417  Ig5_Contactin_like
pfam00041529-607  fn3
pfam00041946-1034  fn3
pfam00041625-708  fn3
cd05725348-417  Ig3_Robo
cd05747329-407  Ig5_Titin_like
cd0769341-137  Ig1_Robo
smart00060429-511  FN3
cd05728242-327  Ig4_Contactin-2-like
smart00060946-1031  FN3
cd05722241-327  Ig1_Neogenin
cd05764154-223  Ig_2
cd04978154-217  Ig4_L1-NrCAM_like
cd0572445-136  Ig2_Robo
cd05725157-216  Ig3_Robo
smart00060726-805  FN3
cd07693330-413  Ig1_Robo
cd05745154-221  Ig3_Peroxidasin
cd05745344-417  Ig3_Peroxidasin
cd05724351-417  Ig2_Robo
cd05722332-405  Ig1_Neogenin
cd05736257-317  Ig2_Follistatin_like
cd05765154-220  Ig_3
cd05724145-230  Ig2_Robo
cd05851145-216  Ig3_Contactin-1
pfam13895245-327  Ig_2
cd05722141-222  Ig1_Neogenin
cd04969254-326  Ig5_Contactin_like
cd05857348-417  Ig2_FGFR
cd04968147-230  Ig3_Contactin_like
cd05746348-415  Ig4_Peroxidasin
cd04968337-417  Ig3_Contactin_like
pfam00041430-514  fn3
cd05726154-220  Ig4_Robo
cd04967242-313  Ig1_Contactin
cd07693139-216  Ig1_Robo
cd04972334-417  Ig_TrkABC_d4
cd05731348-410  Ig3_L1-CAM_like
cd05730352-417  Ig3_NCAM-1_like
cd05736352-417  Ig2_Follistatin_like
cd05730244-329  Ig3_NCAM-1_like
cd05728153-230  Ig4_Contactin-2-like
cd04978254-328  Ig4_L1-NrCAM_like
cd04969154-216  Ig5_Contactin_like
cd04978347-417  Ig4_L1-NrCAM_like
cd05763159-224  Ig_1
cd05748354-417  Ig_Titin_like
cd05738161-230  Ig2_RPTP_IIa_LAR_like
smart00060846-929  FN3
cd05852351-417  Ig5_Contactin-1
cd05848242-313  Ig1_Contactin-5
pfam13895145-230  Ig_2
cd05867154-216  Ig4_L1-CAM_like
cd05725257-327  Ig3_Robo
cd05757269-329  Ig2_IL1R_like
pfam13927246-314  Ig_3
cd05851339-417  Ig3_Contactin-1
pfam07686244-327  V-set
cd05729154-220  Ig2_FGFR_like
pfam00047154-214  ig
cd05747243-327  Ig5_Titin_like
cd04976263-329  Ig2_VEGFR
cd04967331-407  Ig1_Contactin
cd05737246-329  Ig_Myomesin_like_C
cd05729259-327  Ig2_FGFR_like
cd05733157-229  Ig6_L1-CAM_like
cd0496742-132  Ig1_Contactin
cd05856153-218  Ig2_FGFRL1-like
pfam00041846-932  fn3
cd05732143-217  Ig5_NCAM-1_like
cd05744259-327  Ig_Myotilin_C_like
cd05894246-329  Ig_C5_MyBP-C
cd05849331-412  Ig1_Contactin-1
cd05736159-218  Ig2_Follistatin_like
cd05849242-313  Ig1_Contactin-1
cd05729348-407  Ig2_FGFR_like
pfam00047254-312  ig
cd05876351-410  Ig3_L1-CAM
cd05892259-309  Ig_Myotilin_C
cd05735349-423  Ig8_DSCAM
cd05743154-216  Ig_Perlecan_D2_like
cd05747139-227  Ig5_Titin_like
cd05856259-327  Ig2_FGFRL1-like
cd05893259-327  Ig_Palladin_C
cd05848331-407  Ig1_Contactin-5
cd05746157-217  Ig4_Peroxidasin
cd05731258-329  Ig3_L1-CAM_like
pfam00041727-807  fn3
pfam00047352-402  ig
cd05726348-417  Ig4_Robo
cd05723157-218  Ig4_Neogenin
cd05763349-417  Ig_1
cd05734258-313  Ig7_DSCAM
cd05733348-409  Ig6_L1-CAM_like
cd05763257-328  Ig_1
cd0009657-133  Ig
cd05734157-216  Ig7_DSCAM
cd05891246-329  Ig_M-protein_C
cd05744348-417  Ig_Myotilin_C_like
cd05750258-325  Ig_Pro_neuregulin
cd05748263-329  Ig_Titin_like
cd05868254-328  Ig4_NrCAM
cd05864265-329  Ig2_VEGFR-2
cd0496846-119  Ig3_Contactin_like
cd05852254-310  Ig5_Contactin-1
pfam07686145-230  V-set
cd05737352-407  Ig_Myomesin_like_C
cd05893348-417  Ig_Palladin_C
cd05895258-325  Ig_Pro_neuregulin-1
cd04968244-319  Ig3_Contactin_like
cd05891344-407  Ig_M-protein_C
cd05892348-417  Ig_Myotilin_C
pfam13927348-404  Ig_3
cd05737149-224  Ig_Myomesin_like_C
pfam09294625-710  Interfer-bind
pfam1389545-136  Ig_2
cd07702263-329  Ig2_VEGFR-1
cd05750353-415  Ig_Pro_neuregulin
cd05731157-220  Ig3_L1-CAM_like
cd05760157-220  Ig2_PTK7
cd05745253-327  Ig3_Peroxidasin
cd05869147-217  Ig5_NCAM-1
cd05874348-412  Ig6_NrCAM
cd05874157-229  Ig6_NrCAM
cd05891149-216  Ig_M-protein_C
cd05870143-223  Ig5_NCAM-2
cd0497854-120  Ig4_L1-NrCAM_like
cd05857154-220  Ig2_FGFR
cd05857259-327  Ig2_FGFR
cd05868352-407  Ig4_NrCAM
cd05732339-417  Ig5_NCAM-1_like
cd05875157-229  Ig6_hNeurofascin_like
cd04972143-220  Ig_TrkABC_d4
cd04979246-311  Ig_Semaphorin_C
cd04974347-417  Ig3_FGFR
cd05730150-218  Ig3_NCAM-1_like
cd05852154-216  Ig5_Contactin-1
cd05873273-318  Ig_Sema4D_like
cd05867254-328  Ig4_L1-CAM_like
cd0575770-136  Ig2_IL1R_like
pfam12306865-989  PixA
cl20454865-989  PixA superfamily
pfam13895337-417  Ig_2
cd05850331-407  Ig1_Contactin-2
cd04977350-410  Ig1_NCAM-1_like
cd05765254-327  Ig_3
cd04967157-226  Ig1_Contactin
cd05732248-310  Ig5_NCAM-1_like
cd05897273-328  Ig2_IL1R2_like
cd00098242-314  IgC
cd0573457-131  Ig7_DSCAM
cd04970257-331  Ig6_Contactin_like
cd05870248-310  Ig5_NCAM-2
cd05774246-327  Ig_CEACAM_D1
cd05894348-417  Ig_C5_MyBP-C
cd05739352-415  Ig3_RPTP_IIa_LAR_like
cd05850157-229  Ig1_Contactin-2
cd04973147-222  Ig1_FGFR
cd04972243-327  Ig_TrkABC_d4
cd05717247-327  Ig1_Necl-1-3_like
cd0586754-119  Ig4_L1-CAM_like
cd05850242-313  Ig1_Contactin-2
pfam065831146-1445  Neogenin_C
pfam07679331-417  I-set
pfam07679241-327  I-set
smart00408153-219  IGc2
smart0040854-120  IGc2
smart00410246-327  IG_like
smart00409246-327  IG
smart00410337-417  IG_like
smart00409337-417  IG
pfam07679141-222  I-set
smart00409147-224  IG
smart00410147-224  IG_like
smart00408347-407  IGc2
smart00408253-313  IGc2
PHA032471168-1416  PHA03247
smart0041046-136  IG_like
smart0040946-136  IG
pfam031541158-1414  Atrophin-1
PTZ004491142-1365  PTZ00449
pfam031541188-1424  Atrophin-1
PHA02826292-400  PHA02826
PHA032471168-1414  PHA03247
PHA033791163-1419  PHA03379
PHA032471168-1428  PHA03247
pfam072231192-1375  DUF1421
PHA033781173-1403  PHA03378
pfam031541122-1375  Atrophin-1
pfam0767941-120  I-set
pfam096061243-1358  Med15
PRK102631252-1359  PRK10263
PHA033771259-1427  PHA03377
PRK123231204-1439  PRK12323
PRK070031223-1373  PRK07003
pfam051091166-1434  Herpes_BLLF1
PHA02826206-328  PHA02826
PHA032471262-1417  PHA03247
PHA033781208-1405  PHA03378


Ontology Information


   
HPRD ID122
Molecular ClassCell surface receptor
Molecular FunctionProtease inhibitor activity (GO:0030414)
Biological ProcessProtein metabolism (GO:0019538)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO