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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
AGXT 189 alanine-glyoxylate aminotransferase  2AGXT1, PH1, AGT, SPT, AGT1 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
26261061   2015Cell line : -

Source : -

Sample Type : Blood samples

No. of Sample : 519

Stage : TNM Stage IV

GenotypingPolymorhpism-The AGXT-rs34116584 and the ERCC2-rs238406 polymorphisms were significantly associated with progression-free survival.


Gene Details



NC_000002.11 (241808162..241818536)

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Gene Type protein coding
Gene Family -
Description This gene is expressed only in the liver and the encoded protein is localized mostly in the peroxisomes, where it is involved in glyoxylate detoxification. Mutations in this gene, some of which alter subcellular targetting, have been associated with type I primary hyperoxaluria. [provided by RefSeq, Jul 2008]  
Chromosome 2
Location 2q37.3
Start 241808162  
End 241818536  
Strand +  
Gene Sequence

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Length 10375  
OMIM ID 604285   
HGNC ID HGNC:341   
Unigene ID Hs.144567   
Ensembl ID ENSG00000172482   
PharmGKB ID PA24633   

mRNA Information


mRNA ID NM_000030.2
Exon join(1..286,426..618,1900..1964,2605..2705,4235..4305, 5234..5318,6365..6460,7191..7260,8793..8888,9278..9406, 9970..10375)  
mRNA Sequence

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Length 1611  



CDS Information


   
Location122..1300
CDS Sequence

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CCDS ID CCDS2543.1



Protein Information


      
Protein IDNP_000021.1
Protein Namealanine-glyoxylate aminotransferase
Molecular Wt. (Da)42879
Protein Sequence

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Length 392  
Uniprot IDP10636
Ensembl Protein ID ENSP00000262410  



Post-translational Modification Information (Source : HPRD)


No matching records could be found.

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                              
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
5830PEX52684NP_001124495.1in vivo15911627   
9627SNCAIP4804NP_005451.2yeast 2-hybrid16169070   


Pathway Information


                                    
Pathway Name Pathway ID
Alanine, aspartate and glutamate metabolism hsa00250
Carbon metabolism hsa01200
Glycine, serine and threonine metabolism hsa00260
Glyoxylate and dicarboxylate metabolism hsa00630
Metabolic pathways hsa01100
Peroxisome hsa04146


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd0645124-385  AGAT_like
cl1894524-385  AAT_I superfamily
cd0149457-220  AAT_I
TIGR0197756-380  am_tr_V_EF2568
COG1104117-386  NifS
TIGR04343118-216  egtE_PLP_lyase
cd06453117-380  SufS_like
TIGR03402117-216  FeS_nifS
TIGR03235117-327  DNA_S_dndA
PRK02948140-209  PRK02948
COG3844121-284  Bna5
TIGR02006117-216  IscS
cd0645285-214  SepCysS
TIGR0253987-236  SepCysS
PRK14012117-203  PRK14012
TIGR03403117-216  nifS_epsilon
COG1103117-238  COG1103
COG062681-212  MetC
cd0060976-185  AAT_like
PRK07179120-189  PRK07179
COG007521-384  PucG
PLN0240921-368  PLN02409
pfam0026625-376  Aminotran_5
TIGR0330124-384  PhnW-AepZ
TIGR0232622-333  transamin_PhnW
PRK1347924-334  PRK13479
COG052089-386  CsdA
TIGR01814129-326  kynureninase
pfam0015566-380  Aminotran_1_2
pfam0121294-225  Beta_elim_lyase


Ontology Information


   
HPRD ID3275
Molecular ClassEnzyme: Aminotransferase
Molecular FunctionCatalytic activity (GO:0003824)
Biological ProcessMetabolism (GO:0008152); Energy pathways (GO:0006091)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
P21549DB00133L-SerineSmallMoleculeDrug
P21549DB00145GlycineSmallMoleculeDrug
P21549DB00160L-AlanineSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO