Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| AGXT | 189 | alanine-glyoxylate aminotransferase  | 2 | AGXT1, PH1, AGT, SPT, AGT1  |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 26261061    | 2015 | Cell line : - Source : - Sample Type : Blood samples No. of Sample : 519 Stage : TNM Stage IV | Genotyping | Polymorhpism | - | The AGXT-rs34116584 and the ERCC2-rs238406 polymorphisms were significantly associated with progression-free survival. |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene is expressed only in the liver and the encoded protein is localized mostly in the peroxisomes, where it is involved in glyoxylate detoxification. Mutations in this gene, some of which alter subcellular targetting, have been associated with type I primary hyperoxaluria. [provided by RefSeq, Jul 2008]   | Chromosome | 2 |
| Location | 2q37.3 |
| Start | 241808162   |
| End | 241818536   |
| Strand | +   |
| Gene Sequence |    Download   Select all |
| Length | 10375   |
| OMIM ID | 604285    |
| HGNC ID | HGNC:341    |
| Unigene ID | Hs.144567    |
| Ensembl ID | ENSG00000172482    |
| PharmGKB ID | PA24633    |
mRNA Information
| mRNA ID | NM_000030.2 |
|---|---|
| Exon | join(1..286,426..618,1900..1964,2605..2705,4235..4305, 5234..5318,6365..6460,7191..7260,8793..8888,9278..9406, 9970..10375)   | mRNA Sequence |    Download   Select all |
| Length | 1611   |
CDS Information
| Location | 122..1300 |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | CCDS2543.1 |    
Protein Information
| Protein ID | NP_000021.1 |
|---|---|
| Protein Name | alanine-glyoxylate aminotransferase |
| Molecular Wt. (Da) | 42879 |
| Protein Sequence |    Download   Select all |
| Length | 392   |
| Uniprot ID | P10636 |    
| Ensembl Protein ID | ENSP00000262410   |    
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 5830 |    PEX5 |    2684 |    NP_001124495.1 |    in vivo |    15911627    |
| 9627 |    SNCAIP |    4804 |    NP_005451.2 |    yeast 2-hybrid |    16169070    |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Alanine, aspartate and glutamate metabolism |    hsa00250 |    
| Carbon metabolism |    hsa01200 |    
| Glycine, serine and threonine metabolism |    hsa00260 |    
| Glyoxylate and dicarboxylate metabolism |    hsa00630 |    
| Metabolic pathways |    hsa01100 |    
| Peroxisome |    hsa04146 |    
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd06451 | 24-385  | AGAT_like |
| cl18945 | 24-385  | AAT_I superfamily |
| cd01494 | 57-220  | AAT_I |
| TIGR01977 | 56-380  | am_tr_V_EF2568 |
| COG1104 | 117-386  | NifS |
| TIGR04343 | 118-216  | egtE_PLP_lyase |
| cd06453 | 117-380  | SufS_like |
| TIGR03402 | 117-216  | FeS_nifS |
| TIGR03235 | 117-327  | DNA_S_dndA |
| PRK02948 | 140-209  | PRK02948 |
| COG3844 | 121-284  | Bna5 |
| TIGR02006 | 117-216  | IscS |
| cd06452 | 85-214  | SepCysS |
| TIGR02539 | 87-236  | SepCysS |
| PRK14012 | 117-203  | PRK14012 |
| TIGR03403 | 117-216  | nifS_epsilon |
| COG1103 | 117-238  | COG1103 |
| COG0626 | 81-212  | MetC |
| cd00609 | 76-185  | AAT_like |
| PRK07179 | 120-189  | PRK07179 |
| COG0075 | 21-384  | PucG |
| PLN02409 | 21-368  | PLN02409 |
| pfam00266 | 25-376  | Aminotran_5 |
| TIGR03301 | 24-384  | PhnW-AepZ |
| TIGR02326 | 22-333  | transamin_PhnW |
| PRK13479 | 24-334  | PRK13479 |
| COG0520 | 89-386  | CsdA |
| TIGR01814 | 129-326  | kynureninase |
| pfam00155 | 66-380  | Aminotran_1_2 |
| pfam01212 | 94-225  | Beta_elim_lyase |
Ontology Information
| HPRD ID | 3275 |    
|---|---|
| Molecular Class | Enzyme: Aminotransferase |
| Molecular Function | Catalytic activity (GO:0003824) |
| Biological Process | Metabolism (GO:0008152); Energy pathways (GO:0006091)   |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P21549 | DB00133 | L-Serine | SmallMoleculeDrug |
| P21549 | DB00145 | Glycine | SmallMoleculeDrug |
| P21549 | DB00160 | L-Alanine | SmallMoleculeDrug |
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
