Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| EIF4EBP1 | 1978 | eukaryotic translation initiation factor 4E binding protein 1  | 8 | PHAS-I, 4E-BP1  |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22262166    | 2012 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Western blotting, Immunoprecipitation | Phosphorylation | - | 4E-BP1 phosphorylation is a predictive biomarker for mTorKI sensitivity and resistance. |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | |
| Description | This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.   |
| Chromosome | 8 |
| Location | 8p12 |
| Start | 38030502   |
| End | 38060365   |
| Strand | +   |
| Gene Sequence |    Download   Select all |
| Length | 29864   |
| OMIM ID | 602223    |
| HGNC ID | HGNC:3288    |
| Unigene ID | Hs.411641    |
| Ensembl ID | ENSG00000187840    |
| PharmGKB ID | -    |
mRNA Information
| mRNA ID | NM_004095.3 |
|---|---|
| Exon | join(1..217,26580..26759,29403..29864)   | mRNA Sequence |    Download   Select all |
| Length | 877   |
CDS Information
| Location | join(73..217,26580..26759,29403..29434) |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | CCDS6100.1 |    
Protein Information
| Protein ID | NP_004086.1 |
|---|---|
| Protein Name | eukaryotic translation initiation factor 4E binding protein 1 |
| Molecular Wt. (Da) | 12449 |
| Protein Sequence |    Download   Select all |
| Length | 118   |
| Uniprot ID | P21266 |    
| Ensembl Protein ID | ENSP00000256594   |    
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| T | Phosphorylation | 37 |
| T | Phosphorylation | 46 |
| S | Phosphorylation | 65 |
| T | Phosphorylation | 70 |
| S | Phosphorylation | 83 |
| T | Phosphorylation | 46 |
| T | Phosphorylation | 37 |
| S | Phosphorylation | 65 |
| T | Phosphorylation | 37 |
| T | Phosphorylation | 46 |
| S | Phosphorylation | 65 |
| T | Phosphorylation | 70 |
| S | Phosphorylation | 83 |
| S | Phosphorylation | 101 |
| S | Phosphorylation | 112 |
| T | Phosphorylation | 36 |
| T | Phosphorylation | 45 |
| S | Phosphorylation | 112 |
| S | Phosphorylation | 112 |
| T | Phosphorylation | 37 |
| T | Phosphorylation | 46 |
| S | Phosphorylation | 65 |
| S | Phosphorylation | 65 |
| S | Phosphorylation | 65 |
| S | Phosphorylation | 65 |
| T | Phosphorylation | 70 |
| T | Phosphorylation | 36 |
| T | Phosphorylation | 45 |
| S | Phosphorylation | 65;- |
| T | Phosphorylation | 70;- |
| T | Phosphorylation | 50;- |
| S | Phosphorylation | 85;- |
| S | Phosphorylation | 86;- |
| S | Phosphorylation | 94;- |
| S | Phosphorylation | 96;- |
| Y | Phosphorylation | 34 |
| S | Phosphorylation | 35 |
| T | Phosphorylation | 41 |
| S | Phosphorylation | 44 |
| Y | Phosphorylation | 54 |
| T | Phosphorylation | 68 |
| T | Phosphorylation | 77 |
| T | Phosphorylation | 82 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1977 |    EIF4E |    591 |    NP_001124151.1 |    in vitro;in vivo |    1   160   565   816   648   480   000   000   000   000   000   000   000   000   000   000   000   000   000   000   000   000   000   000   000   000   000   000   000   000   000   000    |
| 4597 |    MVD |    4454 |    NP_002452.1 |    yeast 2-hybrid |    16169070    |
| 54921 |    CHTF8 |    16797 |    NP_060274.3 |    yeast 2-hybrid |    16189514    |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Acute myeloid leukemia |    hsa05221 |    
| AMPK signaling pathway |    hsa04152 |    
| Choline metabolism in cancer |    hsa05231 |    
| ErbB signaling pathway |    hsa04012 |    
| HIF-1 signaling pathway |    hsa04066 |    
| Insulin signaling pathway |    hsa04910 |    
| Longevity regulating pathway - mammal |    hsa04211 |    
| mTOR signaling pathway |    hsa04150 |    
| PI3K-Akt signaling pathway |    hsa04151 |    
| RNA transport |    hsa03013 |    
Structure Information
| PDB ID | 1EJ4 |
|---|---|
| Resolution | 2.25 |
| Method | X-RAY DIFFRACTION |
| Chains | A   |
| Molecule | EUKARYOTIC INITIATION FACTOR 4E   |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam05456 | 5-118  | eIF_4EBP |
| cl05167 | 5-118  | eIF_4EBP superfamily |
Ontology Information
| HPRD ID | 1799 |    
|---|---|
| Molecular Class | Translation regulatory protein |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)   |
Drug Information
No matching records could be found.
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
