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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
EIF4EBP1 1978 eukaryotic translation initiation factor 4E binding protein 1  8PHAS-I, 4E-BP1 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
22262166   2012Cell line : -

Source : -

Sample Type : -

No. of Sample : -

Stage : -

Western blotting, ImmunoprecipitationPhosphorylation-4E-BP1 phosphorylation is a predictive biomarker for mTorKI sensitivity and resistance.


Gene Details



Chromosome 8 - NC_000008.11 (38030502..38060365)

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Gene Type protein coding
Gene Family
Description This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.  
Chromosome 8
Location 8p12
Start 38030502  
End 38060365  
Strand +  
Gene Sequence

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Length 29864  
OMIM ID 602223   
HGNC ID HGNC:3288   
Unigene ID Hs.411641   
Ensembl ID ENSG00000187840   
PharmGKB ID -   

mRNA Information


mRNA ID NM_004095.3
Exon join(1..217,26580..26759,29403..29864)  
mRNA Sequence

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Length 877  



CDS Information


   
Location join(73..217,26580..26759,29403..29434)
CDS Sequence

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CCDS ID CCDS6100.1



Protein Information


      
Protein IDNP_004086.1
Protein Nameeukaryotic translation initiation factor 4E binding protein 1
Molecular Wt. (Da)12449
Protein Sequence

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Length 118  
Uniprot IDP21266
Ensembl Protein ID ENSP00000256594  



Post-translational Modification Information (Source : HPRD)


Residue Type site
TPhosphorylation37
TPhosphorylation46
SPhosphorylation65
TPhosphorylation70
SPhosphorylation83
TPhosphorylation46
TPhosphorylation37
SPhosphorylation65
TPhosphorylation37
TPhosphorylation46
SPhosphorylation65
TPhosphorylation70
SPhosphorylation83
SPhosphorylation101
SPhosphorylation112
TPhosphorylation36
TPhosphorylation45
SPhosphorylation112
SPhosphorylation112
TPhosphorylation37
TPhosphorylation46
SPhosphorylation65
SPhosphorylation65
SPhosphorylation65
SPhosphorylation65
TPhosphorylation70
TPhosphorylation36
TPhosphorylation45
SPhosphorylation65;-
TPhosphorylation70;-
TPhosphorylation50;-
SPhosphorylation85;-
SPhosphorylation86;-
SPhosphorylation94;-
SPhosphorylation96;-
YPhosphorylation34
SPhosphorylation35
TPhosphorylation41
SPhosphorylation44
YPhosphorylation54
TPhosphorylation68
TPhosphorylation77
TPhosphorylation82

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                             
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
1977EIF4E591NP_001124151.1in vitro;in vivo1   160   565   816   648   480   000   000   000   000   000   000   000   000   000   000   000   000   000   000   000   000   000   000   000   000   000   000   000   000   000   000   
4597MVD4454NP_002452.1yeast 2-hybrid16169070   
54921CHTF816797NP_060274.3yeast 2-hybrid16189514   


Pathway Information


                                                            
Pathway Name Pathway ID
Acute myeloid leukemia hsa05221
AMPK signaling pathway hsa04152
Choline metabolism in cancer hsa05231
ErbB signaling pathway hsa04012
HIF-1 signaling pathway hsa04066
Insulin signaling pathway hsa04910
Longevity regulating pathway - mammal hsa04211
mTOR signaling pathway hsa04150
PI3K-Akt signaling pathway hsa04151
RNA transport hsa03013


Structure Information


PDB ID1EJ4
Resolution2.25
MethodX-RAY DIFFRACTION
Chains A  
Molecule EUKARYOTIC INITIATION FACTOR 4E  
Model View



Domain Information




ID Location Description
pfam054565-118  eIF_4EBP
cl051675-118  eIF_4EBP superfamily


Ontology Information


   
HPRD ID1799
Molecular ClassTranslation regulatory protein
Molecular FunctionTranscription factor activity (GO:0003700)
Biological ProcessRegulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO