Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| TUBB | 203068 | Tubulin, beta  | 6 | M40; TUBB1; TUBB5; OK/SW-cl.56  |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20812987    | 2010 | Cell line : - Source : Nanfang Hospital tumour tissue bank. Sample Type : CRC tumor and normal tissue No. of Sample : 150 Stage : - | 2-D Ggel electrophoresis, and mass spectrometry,Western blotting, Immunohistochemistry | Up-regulation | - | This gene differentially expressed in between normal colorectal tissue and colorectal cancer tissue experiment done by 2-D Gel eclectrophotesis. |
| 22564821    | 2012 | Cell line : - Source : Chonnam National University Hwasun Hospital National Biobank of Korea. Sample Type : CRC tumor and normal tissue No. of Sample : 13 Stage : TNM Stage I-IV | Western blotting, Personal proteomics and a Heat map tools. | Up-regulation | 4.2 | KRT5, JUP, TUBB, and COL6A1 proteins gave specific network information for CRC, and yielded a panel of novel markers and potential targets for treatment. |
| 24618180    | 2014 | Cell line : - Source : Central Hospital of the People?s Liberation Army (PLA) Cancer Center Sample Type : Blood plasma No. of Sample : 70 healthy volunteers and 72 CRC Stage : - | Mass spectrometry | Up-regulation | - | Alpha-2-HS-glycoprotein precursor and tubulin beta chain could be involved in the pathogenesis of CRC and perform as potential serology diagnosis biomarker. Identified beta-tubulin up-regulated in CRC, which show great potential for diagnosis for CRC. |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | Tubulins |
| Description | -   |
| Chromosome | 6 |
| Location | 6p21.33 |
| Start | 30720201   |
| End | 30725426   |
| Strand | -   |
| Gene Sequence |    Download   Select all |
| Length | 5226   |
| OMIM ID | 191130    |
| HGNC ID | HGNC:20778    |
| Unigene ID | Hs.636480     |
| Ensembl ID | ENSG00000196230    |
| PharmGKB ID | -    |
mRNA Information
| mRNA ID | NM_178014.3 |
|---|---|
| Exon | join(1..363,2337..2445,2718..2828,3140..5226)   | mRNA Sequence |    Download   Select all |
| Length | 2688   |
CDS Information
| Location | join(307..363,2337..2445,2718..2828,3140..4197) |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | CCDS4687.1 |    
Protein Information
| Protein ID | NP_001280141.1 |
|---|---|
| Protein Name | Tubulin, beta |
| Molecular Wt. (Da) | 51887 |
| Protein Sequence |    Download   Select all |
| Length | 464   |
| Uniprot ID | Q13480 |    
| Ensembl Protein ID | ENSP00000262994   |    
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 275 |
| S | Phosphorylation | 275 |
| Y | Phosphorylation | 36;- |
| S | Phosphorylation | 48 |
| T | Phosphorylation | 55 |
| T | Phosphorylation | 429 |
| K | Acetylation | 58 |
| S | Phosphorylation | 25 |
| Y | Phosphorylation | 50 |
| Y | Phosphorylation | 51 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 226 |    ALDOA |    70 |    NP_000025.1 |    in vitro |    8103323    |
| 3064 |    HTT |    883 |    NP_002102.4 |    in vitro;in vivo |    11870213    |
| 4134 |    MAP4 |    1141 |    NP_002366.2 |    in vitro |    12855424    |
| 4137 |    MAPT |    1142 |    NP_001116538.1 |    in vitro |    9922135    |
| 4599 |    MX1 |    919 |    NP_002453.2 |    in vivo |    1629950    |
| 5071 |    PARK2 |    3967 |    NP_004553.2 |    in vivo |    12716939    |
| 7052 |    TGM2 |    1825 |    NP_004604.2 |    in vitro;in vivo |    9973324    |
| 9672 |    SDC3 |    1719 |    NP_055469.3 |    in vitro |    9553134    |
| 10399 |    GNB2L1 |    1503 |    NP_006089.1 |    in vitro;in vivo |    12884273    |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Gap junction |    hsa04540 |    
| Pathogenic Escherichia coli infection |    hsa05130 |    
| Phagosome |    hsa04145 |    
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd02187 | 2-426  | beta_tubulin |
| cl10017 | 2-426  | Tubulin_FtsZ_Cetz-like superfamily |
| cd06059 | 3-424  | Tubulin |
| cd02186 | 2-424  | alpha_tubulin |
| cd00286 | 3-371  | Tubulin_FtsZ_Cetz-like |
| cd02188 | 2-422  | gamma_tubulin |
| cd02190 | 2-425  | epsilon_tubulin |
| pfam03953 | 261-383  | Tubulin_C |
| cd02189 | 4-424  | delta_zeta_tubulin-like |
| smart00864 | 57-244  | Tubulin |
| cl19178 | 57-244  | Tubulin superfamily |
| smart00865 | 246-383  | Tubulin_C |
| pfam10644 | Feb-78  | Misat_Tub_SegII |
| cl10534 | Feb-78  | Misat_Tub_SegII superfamily |
| cd06060 | Feb-79  | misato |
| PLN00220 | 1-429  | PLN00220 |
| PTZ00010 | 1-429  | PTZ00010 |
| COG5023 | 1-429  | COG5023 |
| PTZ00335 | 1-424  | PTZ00335 |
| PLN00221 | 1-424  | PLN00221 |
| PLN00222 | 2-423  | PLN00222 |
| PTZ00387 | 1-428  | PTZ00387 |
| pfam00091 | 4-224  | Tubulin |
Ontology Information
| HPRD ID | 8357 |    
|---|---|
| Molecular Class | Cytoskeletal protein |
| Molecular Function | Catalytic activity (GO:0003824) |
| Biological Process | Metabolism (GO:0008152); Energy pathways (GO:0006091)   |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P07437 | DB00361 | Vinorelbine | SmallMoleculeDrug |
| P07437 | DB00541 | Vincristine | SmallMoleculeDrug |
| P07437 | DB00570 | Vinblastine | SmallMoleculeDrug |
| P07437 | DB01179 | Podofilox | SmallMoleculeDrug |
| P07437 | DB01394 | Colchicine | SmallMoleculeDrug |
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
