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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
TUBB 203068 Tubulin, beta  6M40; TUBB1; TUBB5; OK/SW-cl.56 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
20812987   2010Cell line : -

Source : Nanfang Hospital tumour tissue bank.

Sample Type : CRC tumor and normal tissue

No. of Sample : 150

Stage : -

2-D Ggel electrophoresis, and mass spectrometry,Western blotting, ImmunohistochemistryUp-regulation-This gene differentially expressed in between normal colorectal tissue and colorectal cancer tissue experiment done by 2-D Gel eclectrophotesis.

22564821   2012Cell line : -

Source : Chonnam National University Hwasun Hospital National Biobank of Korea.

Sample Type : CRC tumor and normal tissue

No. of Sample : 13

Stage : TNM Stage I-IV

Western blotting, Personal proteomics and a Heat map tools.Up-regulation4.2KRT5, JUP, TUBB, and COL6A1 proteins gave specific network information for CRC, and yielded a panel of novel markers and potential targets for treatment.

24618180   2014Cell line : -

Source : Central Hospital of the People?s Liberation Army (PLA) Cancer Center

Sample Type : Blood plasma

No. of Sample : 70 healthy volunteers and 72 CRC

Stage : -

Mass spectrometryUp-regulation-Alpha-2-HS-glycoprotein precursor and tubulin beta chain could be involved in the pathogenesis of CRC and perform as potential serology diagnosis biomarker.

Identified beta-tubulin up-regulated in CRC, which show great potential for diagnosis for CRC.


Gene Details



Chromosome: 6; NC_000006.11 (30688157..30693199)

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Gene Type protein coding
Gene Family Tubulins
Description -  
Chromosome 6
Location 6p21.33
Start 30720201  
End 30725426  
Strand -  
Gene Sequence

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Length 5226  
OMIM ID 191130   
HGNC ID HGNC:20778   
Unigene ID Hs.636480    
Ensembl ID ENSG00000196230   
PharmGKB ID -   

mRNA Information


mRNA ID NM_178014.3
Exon join(1..363,2337..2445,2718..2828,3140..5226)  
mRNA Sequence

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Length 2688  



CDS Information


   
Locationjoin(307..363,2337..2445,2718..2828,3140..4197)
CDS Sequence

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CCDS ID CCDS4687.1



Protein Information


      
Protein IDNP_001280141.1
Protein NameTubulin, beta
Molecular Wt. (Da)51887
Protein Sequence

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Length 464  
Uniprot IDQ13480
Ensembl Protein ID ENSP00000262994  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation275
SPhosphorylation275
YPhosphorylation36;-
SPhosphorylation48
TPhosphorylation55
TPhosphorylation429
KAcetylation58
SPhosphorylation25
YPhosphorylation50
YPhosphorylation51

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                       
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
226ALDOA70NP_000025.1in vitro8103323   
3064HTT883NP_002102.4in vitro;in vivo11870213   
4134MAP41141NP_002366.2in vitro12855424   
4137MAPT1142NP_001116538.1in vitro9922135   
4599MX1919NP_002453.2in vivo1629950   
5071PARK23967NP_004553.2in vivo12716939   
7052TGM21825NP_004604.2in vitro;in vivo9973324   
9672SDC31719NP_055469.3in vitro9553134   
10399GNB2L11503NP_006089.1in vitro;in vivo12884273   


Pathway Information


                  
Pathway Name Pathway ID
Gap junction hsa04540
Pathogenic Escherichia coli infection hsa05130
Phagosome hsa04145


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd021872-426  beta_tubulin
cl100172-426  Tubulin_FtsZ_Cetz-like superfamily
cd060593-424  Tubulin
cd021862-424  alpha_tubulin
cd002863-371  Tubulin_FtsZ_Cetz-like
cd021882-422  gamma_tubulin
cd021902-425  epsilon_tubulin
pfam03953261-383  Tubulin_C
cd021894-424  delta_zeta_tubulin-like
smart0086457-244  Tubulin
cl1917857-244  Tubulin superfamily
smart00865246-383  Tubulin_C
pfam10644Feb-78  Misat_Tub_SegII
cl10534Feb-78  Misat_Tub_SegII superfamily
cd06060Feb-79  misato
PLN002201-429  PLN00220
PTZ000101-429  PTZ00010
COG50231-429  COG5023
PTZ003351-424  PTZ00335
PLN002211-424  PLN00221
PLN002222-423  PLN00222
PTZ003871-428  PTZ00387
pfam000914-224  Tubulin


Ontology Information


   
HPRD ID8357
Molecular ClassCytoskeletal protein
Molecular FunctionCatalytic activity (GO:0003824)
Biological ProcessMetabolism (GO:0008152); Energy pathways (GO:0006091)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
P07437DB00361VinorelbineSmallMoleculeDrug
P07437DB00541VincristineSmallMoleculeDrug
P07437DB00570VinblastineSmallMoleculeDrug
P07437DB01179PodofiloxSmallMoleculeDrug
P07437DB01394ColchicineSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO