Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| RRAS2 | 22800 | Related RAS viral (r-ras) oncogene homolog 2  | 11 | TC21  |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21531130    | 2011 | Cell line : - Source : Japanees patients Sample Type : CRC tumor and normal tissue No. of Sample : 113 Stage : TNM Stage I-IV | Peptide Nucleic Acid (PNA)-clamp real-timeRT-PCR TaqMan assay, Gene expression profiles. | Up-regulation | - | 113 (55 male nad 23 female with average age 65 year)patients who underwent a surgical resection of the primary CRC were included in this study. |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a member of the R-Ras subfamily of Ras-like small GTPases. The encoded protein associates with the plasma membrane and may function as a signal transducer. This protein may play an important role in activating signal transduction pathways that control cell proliferation. Mutations in this gene are associated with the growth of certain tumors. Pseudogenes of this gene are found on chromosomes 1 and 2. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]   |
| Chromosome | 11 |
| Location | 11p15.2 |
| Start | 14277920   |
| End | 14364506   |
| Strand | -   |
| Gene Sequence |    Download   Select all |
| Length | 86587   |
| OMIM ID | 600098    |
| HGNC ID | HGNC:17271    |
| Unigene ID | Hs.502004     |
| Ensembl ID | ENSG00000133818    |
| PharmGKB ID | -    |
mRNA Information
| mRNA ID | NM_001177314.1 |
|---|---|
| Exon | join(1..116,68652..68739,69645..69747,69928..70036, 82787..82905,85083..86587)   | mRNA Sequence |    Download   Select all |
| Length | 2054   |
CDS Information
| Location | join(114..116,68652..68739,69645..69747,69928..70036, 82787..82905,85083..85170) |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | CCDS53603.1 |    
Protein Information
| Protein ID | NP_001096139.1 |
|---|---|
| Protein Name | Related RAS viral (r-ras) oncogene homolog 2 |
| Molecular Wt. (Da) | 14963 |
| Protein Sequence |    Download   Select all |
| Length | 127   |
| Uniprot ID | Q03112 |    
| Ensembl Protein ID | ENSP00000264674   |    
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 186;- |
| T | Phosphorylation | 190 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 197 |    AHSG |    727 |    NP_001613.2 |    in vitro |    11788587    |
| 369 |    ARAF |    2405 |    NP_001645.1 |    yeast 2-hybrid |    12620389    |
| 4088 |    SMAD3 |    4380 |    NP_005893.1 |    in vivo |    15761153    |
| 4089 |    SMAD4 |    2995 |    NP_005350.1 |    in vivo |    15761153    |
| 4301 |    MLLT4 |    1164 |    NP_001035090.1 |    in vitro;yeast 2-hybrid |    1   178   858   710   224   120    |
| 5295 |    PIK3R1 |    1381 |    NP_852664.1 |    in vivo |    11850823    |
| 5770 |    PTPN1 |    1477 |    NP_002818.1 |    in vitro |    11788587    |
| 5894 |    RAF1 |    1265 |    NP_002871.1 |    in vivo;yeast 2-hybrid |    1   006   459   311   788   580    |
| 64750 |    SMURF2 |    6901 |    NP_073576.1 |    in vivo |    15761153    |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| cAMP signaling pathway |    hsa04024 |    
| HTLV-I infection |    hsa05166 |    
| MAPK signaling pathway |    hsa04010 |    
| Phospholipase D signaling pathway |    hsa04072 |    
| Proteoglycans in cancer |    hsa05205 |    
| Ras signaling pathway |    hsa04014 |    
| Regulation of actin cytoskeleton |    hsa04810 |    
| Tight junction |    hsa04530 |    
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd04145 | 13-176  | M_R_Ras_like |
| cl21455 | 13-176  | P-loop_NTPase superfamily |
| smart00173 | 27-178  | RAS |
| smart00010 | 27-178  | small_GTPase |
| cd00876 | 27-175  | Ras |
| cd04138 | 27-176  | H_N_K_Ras_like |
| cd04144 | 27-203  | Ras2 |
| cd04139 | 27-177  | RalA_RalB |
| cd04177 | 27-176  | RSR1 |
| cd04175 | 27-177  | Rap1 |
| cd04141 | 27-177  | Rit_Rin_Ric |
| cd04136 | 27-175  | Rap_like |
| cd04176 | 27-173  | Rap2 |
| cd04137 | 27-200  | RheB |
| cd00154 | 27-173  | Rab |
| cd04146 | 27-177  | RERG_RasL11_like |
| smart00175 | 27-175  | RAB |
| cd04143 | 27-198  | Rhes_like |
| cd01867 | 27-177  | Rab8_Rab10_Rab13_like |
| cd04140 | 15-172  | ARHI_like |
| cd00157 | 23-174  | Rho |
| cd01868 | 27-175  | Rab11_like |
| cd04148 | 27-176  | RGK |
| cd04147 | 27-173  | Ras_dva |
| cd01862 | 27-173  | Rab7 |
| cd01860 | 27-175  | Rab5_related |
| cd01863 | 27-175  | Rab18 |
| cd01869 | 27-177  | Rab1_Ypt1 |
| cd01866 | 27-177  | Rab2 |
| cd04123 | 27-171  | Rab21 |
| cd01861 | 27-168  | Rab6 |
| cd04111 | 27-175  | Rab39 |
| smart00174 | 23-175  | RHO |
| cd04112 | 27-201  | Rab26 |
| cd04122 | 27-175  | Rab14 |
| cd04113 | 27-175  | Rab4 |
| cd04116 | 27-173  | Rab9 |
| cd04106 | 27-168  | Rab23_like |
| cd00882 | 27-173  | Ras_like_GTPase |
| cd01865 | 59-175  | Rab3 |
| cd04130 | 27-168  | Wrch_1 |
| cd04120 | 63-191  | Rab12 |
| cd04119 | 27-175  | RJL |
| cd01875 | 27-199  | RhoG |
| cd04127 | 64-177  | Rab27A |
| cd01864 | 49-173  | Rab19 |
| cd04121 | 44-191  | Rab40 |
| cd04107 | 27-199  | Rab32_Rab38 |
| cd04117 | 27-171  | Rab15 |
| cd04132 | 23-203  | Rho4_like |
| cd04114 | 27-171  | Rab30 |
| cd04133 | 27-176  | Rop_like |
| cd04101 | 58-173  | RabL4 |
| cd04110 | 27-197  | Rab35 |
| cd04134 | 27-174  | Rho3 |
| cd01874 | 24-172  | Cdc42 |
| cd00877 | 39-173  | Ran |
| cd01871 | 24-175  | Rac1_like |
| cd04129 | 27-203  | Rho2 |
| cd01870 | 27-168  | RhoA_like |
| cd04115 | 27-159  | Rab33B_Rab33A |
| cd04103 | 27-170  | Centaurin_gamma |
| cd04109 | 23-159  | Rab28 |
| cd04118 | 27-199  | Rab24 |
| pfam08477 | 27-130  | Miro |
| cd04135 | 24-175  | Tc10 |
| cd04108 | 27-168  | Rab36_Rab34 |
| cd04142 | 27-173  | RRP22 |
| cd04131 | 27-169  | Rnd |
| cd04124 | 51-173  | RabL2 |
| cd04173 | 27-169  | Rnd2_Rho7 |
| cd04172 | 27-169  | Rnd3_RhoE_Rho8 |
| cd04126 | 27-199  | Rab20 |
| cd04174 | 27-190  | Rnd1_Rho6 |
| cd01893 | 24-169  | Miro1 |
| cd09914 | 56-159  | RocCOR |
| cd04128 | 26-168  | Spg1 |
| cd00878 | 35-168  | Arf_Arl |
| cd04159 | 64-173  | Arl10_like |
| cd01892 | 91-171  | Miro2 |
| cd04152 | 68-146  | Arl4_Arl7 |
| PTZ00369 | 27-204  | PTZ00369 |
| pfam00071 | 27-177  | Ras |
| PLN03118 | 27-171  | PLN03118 |
| COG1100 | 27-182  | Gem1 |
| PLN03108 | 27-180  | PLN03108 |
| TIGR00231 | 27-173  | small_GTP |
| PLN03110 | 27-177  | PLN03110 |
| PTZ00099 | 39-171  | PTZ00099 |
| PTZ00132 | 63-173  | PTZ00132 |
| smart00176 | 63-173  | RAN |
| PLN03071 | 39-173  | PLN03071 |
| PRK12297 | 121-197  | obgE |
Ontology Information
| HPRD ID | 598 |    
|---|---|
| Molecular Class | GTPase |
| Molecular Function | Transferase activity (GO:0016740) |
| Biological Process | Metabolism (GO:0008152); Energy pathways (GO:0006091)   |
Drug Information
No matching records could be found.
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
