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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
RRAS2 22800 Related RAS viral (r-ras) oncogene homolog 2  11TC21 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
21531130   2011Cell line : -

Source : Japanees patients

Sample Type : CRC tumor and normal tissue

No. of Sample : 113

Stage : TNM Stage I-IV

Peptide Nucleic Acid (PNA)-clamp real-timeRT-PCR TaqMan assay, Gene expression profiles.Up-regulation-113 (55 male nad 23 female with average age 65 year)patients who underwent a surgical resection of the primary CRC were included in this study.


Gene Details



Chromosome: 11; NC_000011.9 (14299466..14386052, complement)

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Gene Type protein coding
Gene Family -
Description This gene encodes a member of the R-Ras subfamily of Ras-like small GTPases. The encoded protein associates with the plasma membrane and may function as a signal transducer. This protein may play an important role in activating signal transduction pathways that control cell proliferation. Mutations in this gene are associated with the growth of certain tumors. Pseudogenes of this gene are found on chromosomes 1 and 2. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]  
Chromosome 11
Location 11p15.2
Start 14277920  
End 14364506  
Strand -  
Gene Sequence

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Length 86587  
OMIM ID 600098   
HGNC ID HGNC:17271   
Unigene ID Hs.502004    
Ensembl ID ENSG00000133818   
PharmGKB ID -   

mRNA Information


mRNA ID NM_001177314.1
Exon join(1..116,68652..68739,69645..69747,69928..70036, 82787..82905,85083..86587)  
mRNA Sequence

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Length 2054  



CDS Information


   
Location join(114..116,68652..68739,69645..69747,69928..70036, 82787..82905,85083..85170)
CDS Sequence

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CCDS ID CCDS53603.1



Protein Information


      
Protein IDNP_001096139.1
Protein NameRelated RAS viral (r-ras) oncogene homolog 2
Molecular Wt. (Da)14963
Protein Sequence

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Length 127  
Uniprot IDQ03112
Ensembl Protein ID ENSP00000264674  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation186;-
TPhosphorylation190

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                       
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
197AHSG727NP_001613.2in vitro11788587   
369ARAF2405NP_001645.1yeast 2-hybrid12620389   
4088SMAD34380NP_005893.1in vivo15761153   
4089SMAD42995NP_005350.1in vivo15761153   
4301MLLT41164NP_001035090.1in vitro;yeast 2-hybrid1   178   858   710   224   120   
5295PIK3R11381NP_852664.1in vivo11850823   
5770PTPN11477NP_002818.1in vitro11788587   
5894RAF11265NP_002871.1in vivo;yeast 2-hybrid1   006   459   311   788   580   
64750SMURF26901NP_073576.1in vivo15761153   


Pathway Information


                                                
Pathway Name Pathway ID
cAMP signaling pathway hsa04024
HTLV-I infection hsa05166
MAPK signaling pathway hsa04010
Phospholipase D signaling pathway hsa04072
Proteoglycans in cancer hsa05205
Ras signaling pathway hsa04014
Regulation of actin cytoskeleton hsa04810
Tight junction hsa04530


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd0414513-176  M_R_Ras_like
cl2145513-176  P-loop_NTPase superfamily
smart0017327-178  RAS
smart0001027-178  small_GTPase
cd0087627-175  Ras
cd0413827-176  H_N_K_Ras_like
cd0414427-203  Ras2
cd0413927-177  RalA_RalB
cd0417727-176  RSR1
cd0417527-177  Rap1
cd0414127-177  Rit_Rin_Ric
cd0413627-175  Rap_like
cd0417627-173  Rap2
cd0413727-200  RheB
cd0015427-173  Rab
cd0414627-177  RERG_RasL11_like
smart0017527-175  RAB
cd0414327-198  Rhes_like
cd0186727-177  Rab8_Rab10_Rab13_like
cd0414015-172  ARHI_like
cd0015723-174  Rho
cd0186827-175  Rab11_like
cd0414827-176  RGK
cd0414727-173  Ras_dva
cd0186227-173  Rab7
cd0186027-175  Rab5_related
cd0186327-175  Rab18
cd0186927-177  Rab1_Ypt1
cd0186627-177  Rab2
cd0412327-171  Rab21
cd0186127-168  Rab6
cd0411127-175  Rab39
smart0017423-175  RHO
cd0411227-201  Rab26
cd0412227-175  Rab14
cd0411327-175  Rab4
cd0411627-173  Rab9
cd0410627-168  Rab23_like
cd0088227-173  Ras_like_GTPase
cd0186559-175  Rab3
cd0413027-168  Wrch_1
cd0412063-191  Rab12
cd0411927-175  RJL
cd0187527-199  RhoG
cd0412764-177  Rab27A
cd0186449-173  Rab19
cd0412144-191  Rab40
cd0410727-199  Rab32_Rab38
cd0411727-171  Rab15
cd0413223-203  Rho4_like
cd0411427-171  Rab30
cd0413327-176  Rop_like
cd0410158-173  RabL4
cd0411027-197  Rab35
cd0413427-174  Rho3
cd0187424-172  Cdc42
cd0087739-173  Ran
cd0187124-175  Rac1_like
cd0412927-203  Rho2
cd0187027-168  RhoA_like
cd0411527-159  Rab33B_Rab33A
cd0410327-170  Centaurin_gamma
cd0410923-159  Rab28
cd0411827-199  Rab24
pfam0847727-130  Miro
cd0413524-175  Tc10
cd0410827-168  Rab36_Rab34
cd0414227-173  RRP22
cd0413127-169  Rnd
cd0412451-173  RabL2
cd0417327-169  Rnd2_Rho7
cd0417227-169  Rnd3_RhoE_Rho8
cd0412627-199  Rab20
cd0417427-190  Rnd1_Rho6
cd0189324-169  Miro1
cd0991456-159  RocCOR
cd0412826-168  Spg1
cd0087835-168  Arf_Arl
cd0415964-173  Arl10_like
cd0189291-171  Miro2
cd0415268-146  Arl4_Arl7
PTZ0036927-204  PTZ00369
pfam0007127-177  Ras
PLN0311827-171  PLN03118
COG110027-182  Gem1
PLN0310827-180  PLN03108
TIGR0023127-173  small_GTP
PLN0311027-177  PLN03110
PTZ0009939-171  PTZ00099
PTZ0013263-173  PTZ00132
smart0017663-173  RAN
PLN0307139-173  PLN03071
PRK12297121-197  obgE


Ontology Information


   
HPRD ID598
Molecular ClassGTPase
Molecular FunctionTransferase activity (GO:0016740)
Biological ProcessMetabolism (GO:0008152); Energy pathways (GO:0006091)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO