Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CLCA4 | 22802 | Chloride channel, calcium activated, family member 4  | 1 | CaCC; CaCC2  |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22968445    | 2012 | Cell line : - Source : Department of Pathology of Wrocaw Medical University. Sample Type : - No. of Sample : - Stage : - | Laser capture microdissection,FFPE-FASP,SAX fractionation,LC-MSMS,Label-free quantitation. | Down-regulation | 0.052 | - |
| 23593331    | 2013 | Cell line : - Source : Department of General Surgery, the 309th Hospital of PLA, Beijing, China. Sample Type : - No. of Sample : - Stage : - | - | Down-regulation | - | CLCA1 and CLCA4 expression were down-regulated significantly in CRC patients.
|
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene belongs to the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same site on chromosome 1p31-p22 and share high degrees of homology in size, sequence and predicted structure, but differ significantly in their tissue distributions. Alternative splicing results in multiple transcript variants, only one of which is thought to be protein coding. [provided by RefSeq, Dec 2008]   |
| Chromosome | 1 |
| Location | 1p31-p22 |
| Start | 86547076   |
| End | 86580758   |
| Strand | -   |
| Gene Sequence |    Download   Select all |
| Length | 33683   |
| OMIM ID |     |
| HGNC ID | HGNC:2018    |
| Unigene ID | Hs.567422     |
| Ensembl ID | ENSG00000016602    |
| PharmGKB ID | -    |
mRNA Information
| mRNA ID | NM_012128.3 |
|---|---|
| Exon | join(1..203,12857..12997,13136..13283,16586..16694, 18199..18376,18727..18945,20349..20576,24002..24179, 25539..25645,27465..27680,28257..28524,30827..30997, 32279..32512,32867..33679)   | mRNA Sequence |    Download   Select all |
| Length | 3285   |
CDS Information
| Location | join(45..203,12857..12997,13136..13283,16586..16694, 18199..18376,18727..18945,20349..20576,24002..24179, 25539..25645,27465..27680,28257..28524,30827..30997, 32279..32512,32867..33270) |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | CCDS41355.1 |    
Protein Information
| Protein ID | NP_036260.2 |
|---|---|
| Protein Name | Chloride channel, calcium activated, family member 4 |
| Molecular Wt. (Da) | 98892 |
| Protein Sequence |    Download   Select all |
| Length | 919   |
| Uniprot ID | P34910 |    
| Ensembl Protein ID | ENSP00000333779   |    
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 803 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Pancreatic secretion |    hsa04972 |    
| Renin secretion |    hsa04924 |    
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00198 | 305-459  | vWFA |
| cl00057 | 305-459  | vWFA superfamily |
| pfam08434 | 1-262  | CLCA_N |
| cl07163 | 1-262  | CLCA_N superfamily |
| pfam09315 | 487-663  | DUF1973 |
| cl09605 | 487-663  | DUF1973 superfamily |
| smart00327 | 307-465  | VWA |
| pfam13519 | 307-472  | VWA_2 |
| pfam00092 | 307-473  | VWA |
| cd01465 | 308-465  | vWA_subgroup |
| cd01466 | 306-460  | vWA_C3HC4_type |
| cd01450 | 309-459  | vWFA_subfamily_ECM |
| cd01456 | 307-466  | vWA_ywmD_type |
| cd01464 | 307-443  | vWA_subfamily |
| cd01451 | 305-419  | vWA_Magnesium_chelatase |
| cd01471 | 307-439  | vWA_micronemal_protein |
| cd01467 | 307-464  | vWA_BatA_type |
| cd01461 | 307-465  | vWA_interalpha_trypsin_inhibitor |
| TIGR00868 | 1-862  | hCaCC |
| TIGR03436 | 309-473  | acidobact_VWFA |
| COG1240 | 307-417  | ChlD |
| COG2425 | 306-439  | ViaA |
Ontology Information
| HPRD ID | 9306 |    
|---|---|
| Molecular Class | Voltage gated channel |
| Molecular Function | Transferase activity (GO:0016740) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165)   |
Drug Information
No matching records could be found.
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
