Search results:


General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
CLCA4 22802 Chloride channel, calcium activated, family member 4  1CaCC; CaCC2 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
22968445   2012Cell line : -

Source : Department of Pathology of Wrocaw Medical University.

Sample Type : -

No. of Sample : -

Stage : -

Laser capture microdissection,FFPE-FASP,SAX fractionation,LC-MSMS,Label-free quantitation.Down-regulation0.052-

23593331   2013Cell line : -

Source : Department of General Surgery, the 309th Hospital of PLA, Beijing, China.

Sample Type : -

No. of Sample : -

Stage : -

-Down-regulation-CLCA1 and CLCA4 expression were down-regulated significantly in CRC patients.


Gene Details



Chromosome: 1; NC_000001.10 (87012759..87046437)

View Larger Image
   
Gene Type protein coding
Gene Family -
Description The protein encoded by this gene belongs to the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same site on chromosome 1p31-p22 and share high degrees of homology in size, sequence and predicted structure, but differ significantly in their tissue distributions. Alternative splicing results in multiple transcript variants, only one of which is thought to be protein coding. [provided by RefSeq, Dec 2008]  
Chromosome 1
Location 1p31-p22
Start 86547076  
End 86580758  
Strand -  
Gene Sequence

   Download   Select all

Length 33683  
OMIM ID    
HGNC ID HGNC:2018   
Unigene ID Hs.567422    
Ensembl ID ENSG00000016602   
PharmGKB ID -   

mRNA Information


mRNA ID NM_012128.3
Exon join(1..203,12857..12997,13136..13283,16586..16694, 18199..18376,18727..18945,20349..20576,24002..24179, 25539..25645,27465..27680,28257..28524,30827..30997, 32279..32512,32867..33679)  
mRNA Sequence

   Download   Select all

Length 3285  



CDS Information


   
Location join(45..203,12857..12997,13136..13283,16586..16694, 18199..18376,18727..18945,20349..20576,24002..24179, 25539..25645,27465..27680,28257..28524,30827..30997, 32279..32512,32867..33270)
CDS Sequence

   Download   Select all

CCDS ID CCDS41355.1



Protein Information


      
Protein IDNP_036260.2
Protein NameChloride channel, calcium activated, family member 4
Molecular Wt. (Da)98892
Protein Sequence

   Download   Select all

Length 919  
Uniprot IDP34910
Ensembl Protein ID ENSP00000333779  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation803

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

No matching records from HPRD source could be found.

Pathway Information


            
Pathway Name Pathway ID
Pancreatic secretion hsa04972
Renin secretion hsa04924


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd00198305-459  vWFA
cl00057305-459  vWFA superfamily
pfam084341-262  CLCA_N
cl071631-262  CLCA_N superfamily
pfam09315487-663  DUF1973
cl09605487-663  DUF1973 superfamily
smart00327307-465  VWA
pfam13519307-472  VWA_2
pfam00092307-473  VWA
cd01465308-465  vWA_subgroup
cd01466306-460  vWA_C3HC4_type
cd01450309-459  vWFA_subfamily_ECM
cd01456307-466  vWA_ywmD_type
cd01464307-443  vWA_subfamily
cd01451305-419  vWA_Magnesium_chelatase
cd01471307-439  vWA_micronemal_protein
cd01467307-464  vWA_BatA_type
cd01461307-465  vWA_interalpha_trypsin_inhibitor
TIGR008681-862  hCaCC
TIGR03436309-473  acidobact_VWFA
COG1240307-417  ChlD
COG2425306-439  ViaA


Ontology Information


   
HPRD ID9306
Molecular ClassVoltage gated channel
Molecular FunctionTransferase activity (GO:0016740)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO