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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| FOXO3 | 2309 | Forkhead box O3 | 6 | FOXO2; AF6q21; FKHRL1; FOXO3A; FKHRL1P2 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23592131 | 2013 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Micro-array, RT-PCR, Western Blotting, immunohistochemistry | Down-regulation | - | Downregulation of FoxO3a may greatly contribute to tumor development, and thus FoxO3a may represent a novel therapeutic target in colorectal cancer. |
| 23828518 | 2013 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Tissue microarray | Down-regulation | - | The FOXO3 expression is significantly reduced in CRC specimens compared with normal tissue, and progressive FOXO3 downregulation is associated with advancing pathological stage. FOXO3 may represent a novel biomarker of nodal and distant disease spread with clinical utility in CRC. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Forkhead boxes |
| Description | This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008] |
| Chromosome | 6 |
| Location | 6q21 |
| Start | 108559823 |
| End | 108684769 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 124947 |
| OMIM ID | 602681 |
| HGNC ID | HGNC:3821 |
| Unigene ID | Hs.220950 |
| Ensembl ID | ENSG00000118689 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_201559.2 |
|---|---|
| Exon | join(1..193,1264..2007,103633..105067,120005..124946) | mRNA Sequence | Download Select all |
| Length | 7314 |
CDS Information
| Location | join(1387..2007,103633..105033) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS5068.1 |
Protein Information
| Protein ID | NP_001446.1 |
|---|---|
| Protein Name | Forkhead box O3 |
| Molecular Wt. (Da) | 71146 |
| Protein Sequence | Download Select all |
| Length | 673 |
| Uniprot ID | P18075 |
| Ensembl Protein ID | ENSP00000379204 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 253 |
| S | Phosphorylation | 315 |
| T | Phosphorylation | 32 |
| S | Phosphorylation | 253 |
| S | Phosphorylation | 315 |
| T | Phosphorylation | 32 |
| S | Phosphorylation | 253 |
| T | Phosphorylation | 32 |
| S | Phosphorylation | 253 |
| T | Phosphorylation | 32 |
| S | Phosphorylation | 280 |
| S | Phosphorylation | 284 |
| S | Phosphorylation | 280 |
| S | Phosphorylation | 284 |
| S | Phosphorylation | 299 |
| S | Phosphorylation | 299 |
| S | Phosphorylation | 286 |
| S | Phosphorylation | 286 |
| S | Phosphorylation | 7 |
| S | Phosphorylation | 12 |
| S | Phosphorylation | 7 |
| S | Phosphorylation | 12 |
| S | Phosphorylation | 26 |
| S | Phosphorylation | 26 |
| S | Phosphorylation | 289 |
| S | Phosphorylation | 289 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2033 | EP300 | 4078 | NP_001420.2 | in vitro | 11896584 |
| 3551 | IKBKB | 4462 | NP_001547.1 | in vitro;in vivo | 15084260 |
| 4087 | SMAD2 | 3221 | NP_005892.1 | in vitro;in vivo | 15084259 |
| 4089 | SMAD4 | 2995 | NP_005350.1 | in vitro;in vivo | 15084259 |
| 7534 | YWHAZ | 3183 | NP_003397.1 | in vivo | 10102273 |
| 23411 | SIRT1 | 8381 | NP_036370.2 | in vitro;in vivo;yeast 2-hybrid | 14976264 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| AMPK signaling pathway | hsa04152 |
| Chemokine signaling pathway | hsa04062 |
| Endometrial cancer | hsa05213 |
| FoxO signaling pathway | hsa04068 |
| Longevity regulating pathway - mammal | hsa04211 |
| Longevity regulating pathway - multiple species | hsa04213 |
| Neurotrophin signaling pathway | hsa04722 |
| Non-small cell lung cancer | hsa05223 |
| PI3K-Akt signaling pathway | hsa04151 |
| Prolactin signaling pathway | hsa04917 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00059 | 157-237 | FH |
| cl00061 | 157-237 | FH superfamily |
| smart00339 | 157-239 | FH |
| pfam00250 | 161-249 | Fork_head |
| COG5025 | 151-250 | COG5025 |
| COG5025 | 160-239 | COG5025 |
Ontology Information
| HPRD ID | 212 |
|---|---|
| Molecular Class | Unknown |
| Molecular Function | Receptor binding (GO:0005102) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.